Glycogen synthase kinase-3 regulates mitochondrial outer membrane permeabilization and apoptosis by destabilization of MCL-1 (Q24308005)

extrinsic apoptotic signaling pathway in absence of ligand

1 reference

Glycogen synthase kinase 3 beta

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BCL2-like 11 (apoptosis facilitator)

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Myeloid cell leukemia sequence 1

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Glycogen synthase kinase 3 alpha

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1 reference

Douglas R Green

5

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author name string

Ulrich Maurer

1

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Céline Charvet

2

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Allan S Wagman

3

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Emmanuel Dejardin

ARF-BP1/Mule is a critical mediator of the ARF tumor suppressor

4

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language of work or name

English

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publication date

17 March 2006

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published in

Molecular Cell

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volume

21

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issue

6

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page(s)

749-60

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cites work

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7 January 2021

Apoptotic pathways: ten minutes to dead

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Mule/ARF-BP1, a BH3-only E3 ubiquitin ligase, catalyzes the polyubiquitination of Mcl-1 and regulates apoptosis

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GSK3-mediated BCL-3 phosphorylation modulates its degradation and its oncogenicity

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BH3 domains of BH3-only proteins differentially regulate Bax-mediated mitochondrial membrane permeabilization both directly and indirectly

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PI 3-kinase, Akt and cell survival

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7 January 2021

The (Holey) study of mitochondria in apoptosis

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Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery

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7 January 2021

Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor

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7 January 2021

Rsk1 mediates a MEK-MAP kinase cell survival signal

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7 January 2021

Expression of the pro-apoptotic Bcl-2 family member Bim is regulated by the forkhead transcription factor FKHR-L1

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7 January 2021

In the absence of extrinsic signals, nutrient utilization by lymphocytes is insufficient to maintain either cell size or viability

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7 January 2021

Ras enhances Myc protein stability.

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7 January 2021

A common phosphate binding site explains the unique substrate specificity of GSK3 and its inactivation by phosphorylation

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7 January 2021

BCL-2, BCL-X(L) sequester BH3 domain-only molecules preventing BAX- and BAK-mediated mitochondrial apoptosis

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7 January 2021

Multisite phosphorylation by Cdk2 and GSK3 controls cyclin E degradation

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7 January 2021

Simultaneous inhibition of GSK3alpha and GSK3beta using hairpin siRNA expression vectors.

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7 January 2021

Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics

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7 January 2021

Requirement for glycogen synthase kinase-3beta in cell survival and NF-kappaB activation

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7 January 2021

The renaissance of GSK3

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7 January 2021

Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B

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7 January 2021

NF-kappaB is a target of AKT in anti-apoptotic PDGF signalling

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7 January 2021

Development and maintenance of B and T lymphocytes requires antiapoptotic MCL-1.

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7 January 2021

The costimulation-regulated duration of PKB activation controls T cell longevity

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7 January 2021

Expression of apoptosis inhibitor protein Mcl1 linked to neuroprotection in CNS neurons.

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7 January 2021

Cytochrome c is released in a single step during apoptosis

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7 January 2021

A major role for Mcl-1 antiapoptotic protein in the IL-6-induced survival of human myeloma cells

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7 January 2021

Phosphorylation of Bim-EL by Erk1/2 on serine 69 promotes its degradation via the proteasome pathway and regulates its proapoptotic function.

1 reference

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7 January 2021

MCL1 is phosphorylated in the PEST region and stabilized upon ERK activation in viable cells, and at additional sites with cytotoxic okadaic acid or taxol

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7 January 2021

Cleavage of Mcl-1 by caspases impaired its ability to counteract Bim-induced apoptosis.

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7 January 2021

Selective small-molecule inhibitors of glycogen synthase kinase-3 activity protect primary neurones from death

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7 January 2021

Phosphorylation of insulin receptor substrate 1 by glycogen synthase kinase 3 impairs insulin action

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7 January 2021

Interleukin 3-dependent survival by the Akt protein kinase

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7 January 2021

Role of glycogen synthase kinase-3 in the phosphatidylinositol 3-Kinase/Akt cell survival pathway.

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7 January 2021

Negative regulation of the forkhead transcription factor FKHR by Akt.

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7 January 2021

Glycogen synthase kinase-3beta facilitates staurosporine- and heat shock-induced apoptosis. Protection by lithium

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7 January 2021

Determinants of cytochrome c pro-apoptotic activity. The role of lysine 72 trimethylation

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7 January 2021

Glycogen synthase kinase-3 beta activity is critical for neuronal death caused by inhibiting phosphatidylinositol 3-kinase or Akt but not for death caused by nerve growth factor withdrawal.

1 reference

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7 January 2021

Akt and Bcl-xL promote growth factor-independent survival through distinct effects on mitochondrial physiology

1 reference

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7 January 2021

Activation of the ERK1/2 signaling pathway promotes phosphorylation and proteasome-dependent degradation of the BH3-only protein, Bim.

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7 January 2021

Degradation of Mcl-1 by granzyme B: implications for Bim-mediated mitochondrial apoptotic events

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7 January 2021

Interleukin 3 protects murine bone marrow cells from apoptosis induced by DNA damaging agents

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7 January 2021

Activation of PI3K is indispensable for interleukin 7-mediated viability, proliferation, glucose use, and growth of T cell acute lymphoblastic leukemia cells

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7 January 2021

Akt maintains cell size and survival by increasing mTOR-dependent nutrient uptake

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7 January 2021

The axis-inducing activity, stability, and subcellular distribution of beta-catenin is regulated in Xenopus embryos by glycogen synthase kinase 3

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7 January 2021

Elimination of Mcl-1 is required for the initiation of apoptosis following ultraviolet irradiation

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7 January 2021

The serine/threonine kinase Pim-2 is a transcriptionally regulated apoptotic inhibitor

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7 January 2021

Glycogen synthase kinase-3beta regulates cyclin D1 proteolysis and subcellular localization

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7 January 2021

Proapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins

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https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2006.02.009

7 January 2021

Multiple Ras-dependent phosphorylation pathways regulate Myc protein stability.

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7 January 2021

Inhibition of early apoptotic events by Akt/PKB is dependent on the first committed step of glycolysis and mitochondrial hexokinase

1 reference

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7 January 2021

Glycogen Synthase Kinase-3 from Rabbit Skeletal Muscle

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7 January 2021

Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death

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7 January 2021

Obligate role of anti-apoptotic MCL-1 in the survival of hematopoietic stem cells.

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7 January 2021

Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt

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7 January 2021

Regulation of cell death protease caspase-9 by phosphorylation

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7 January 2021

Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity

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7 January 2021

Akt/Protein kinase B inhibits cell death by preventing the release of cytochrome c from mitochondria

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7 January 2021

The antiapoptotic gene mcl-1 is up-regulated by the phosphatidylinositol 3-kinase/Akt signaling pathway through a transcription factor complex containing CREB

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7 January 2021

Apoptosis suppression by Raf-1 and MEK1 requires MEK- and phosphatidylinositol 3-kinase-dependent signals

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7 January 2021

Egr family members regulate nonlymphoid expression of Fas ligand, TRAIL, and tumor necrosis factor during immune responses

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7 January 2021

Stabilization and enhancement of the antiapoptotic activity of mcl-1 by TCTP

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7 January 2021

VEGF induces Mcl-1 up-regulation and protects multiple myeloma cells against apoptosis

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7 January 2021

Sustained signaling through the B-cell receptor induces Mcl-1 and promotes survival of chronic lymphocytic leukemia B cells.

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7 January 2021

Growth factor withdrawal from primary human erythroid progenitors induces apoptosis through a pathway involving glycogen synthase kinase-3 and Bax.

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7 January 2021

Role of glycogen synthase kinase-3beta in neuronal apoptosis induced by trophic withdrawal

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7 January 2021

Discovery and development of GSK3 inhibitors for the treatment of type 2 diabetes

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7 January 2021

Selective glycogen synthase kinase 3 inhibitors potentiate insulin activation of glucose transport and utilization in vitro and in vivo

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7 January 2021