Natural Products as a Foundation for Drug Discovery (Q33617301)

28 July 2017

Natural Products as a Foundation for Drug Discovery (English)

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28 July 2017

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John A Beutler

1

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28 July 2017

1 September 2009

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Current protocols in pharmacology

28 July 2017

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28 July 2017

46

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28 July 2017

9.11.1-9.11.21

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Exploiting new approaches for natural product drug discovery in the biotechnology industry

28 July 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2813068

Caenorhabditis elegans in Parkinson's disease drug discovery: addressing an unmet medical need

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2813068

Pre-fractionated microbial samples--the second generation natural products library at Wyeth

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2813068

Fractionated marine invertebrate extract libraries for drug discovery

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2813068

Natural products to drugs: natural product-derived compounds in clinical trials

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2813068

Efficient synthetic access to a new family of highly potent bryostatin analogues via a Prins-driven macrocyclization strategy

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2813068

Natural products as leads to potential drugs: an old process or the new hope for drug discovery?

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2813068

Merger of ayurveda and tissue culture-based functional genomics: inspirations from systems biology

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2813068

Biosynthetic origin of natural products isolated from marine microorganism-invertebrate assemblages

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2813068

Bacterial hosts for natural product production.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2813068

Eribulin, a simplified ketone analog of the tubulin inhibitor halichondrin B, for the potential treatment of cancer.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2813068

FTICR-MS applications for the structure determination of natural products

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2813068

Neuronal nicotinic receptors: a perspective on two decades of drug discovery research

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2813068

Oribatid mites as a major dietary source for alkaloids in poison frogs

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2813068

G protein-coupled time travel: evolutionary aspects of GPCR research

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2813068

Natural products as sources of new drugs over the last 25 years

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2813068

Sequestration and possible role of dietary alkaloids in the sponge-feeding mollusk Tylodina perversa

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2813068

Synthesis of OSW saponin analogs with modified sugar residues and their antiproliferative activities

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2813068

Effects and applications of arthropod steroid hormones (ecdysteroids) in mammals

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2813068

Comparison of the activities of the truncated halichondrin B analog NSC 707389 (E7389) with those of the parent compound and a proposed binding site on tubulin.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2813068

Alkaloids from amphibian skin: a tabulation of over eight-hundred compounds

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2813068

In situ DMSO hydration measurements of HTS compound libraries

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2813068

Plants as a source of anti-cancer agents

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2813068

Anticancer activity and mechanism of Scutellaria barbata extract on human lung cancer cell line A549.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2813068

A novel extract SB-300 from the stem bark latex of Croton lechleri inhibits CFTR-mediated chloride secretion in human colonic epithelial cells

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2813068

Formicine ants: An arthropod source for the pumiliotoxin alkaloids of dendrobatid poison frogs

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2813068

Generating Diverse Skeletons of Small Molecules Combinatorially

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2813068

A double blind, randomized, placebo-controlled study of SP-303 (Provir) in the symptomatic treatment of acute diarrhea among travelers to Jamaica and Mexico

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2813068

A polyketide synthase-peptide synthetase gene cluster from an uncultured bacterial symbiont of Paederus beetles

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2813068

High-throughput method for the production and analysis of large natural product libraries for drug discovery

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2813068

Choosing the best pulse sequences, acquisition parameters, postacquisition processing strategies, and probes for natural product structure elucidation by NMR spectroscopy.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2813068

Combinatorial synthesis of natural product-like molecules using a first-generation spiroketal scaffold

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2813068

Tannins: classification and definition

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2813068

Review of antiviral and immunomodulating properties of plants of the Peruvian rainforest with a particular emphasis on Una de Gato and Sangre de Grado

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2813068

Synthesis of 7200 small molecules based on a substructural analysis of the histone deacetylase inhibitors trichostatin and trapoxin

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2813068

Pure compound libraries; a new perspective for natural product based drug discovery

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2813068

Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2813068

Discovery of a novel antitumor benzolactone enamide class that selectively inhibits mammalian vacuolar-type (H+)-atpases.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2813068

A double blind, randomized, placebo-controlled phase II study to assess the safety and efficacy of orally administered SP-303 for the symptomatic treatment of diarrhea in patients with AIDS.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2813068

The discovery and development of marine compounds with pharmaceutical potential

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2813068

Pyranocoumarins from tropical species of the genus Calophyllum: a chemotaxonomic study of extracts in the National Cancer Institute collection

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2813068

Combinatorial chemistry in insects: a library of defensive macrocyclic polyamines

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2813068

Identification of epidermal growth factor receptor and c-erbB2 pathway inhibitors by correlation with gene expression patterns

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2813068

An information-intensive approach to the molecular pharmacology of cancer.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2813068

Taxol and taxane production by Taxomyces andreanae, an endophytic fungus of Pacific yew.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2813068

Treatment of acyclovir-unresponsive cutaneous herpes simplex virus infection with topically applied SP-303.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2813068

A reinvestigation of Maprounea triterpenes

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2813068

Classics in infectious diseases: on the antibacterial action of cultures of a penicillium, with special reference to their use in the isolation of B. influenzae by Alexander Fleming, Reprinted from the British Journal of Experimental Pathology [...]

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2813068

The role of protein kinase C in cell surface signal transduction and tumour promotion

21 June 2018

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2813068

21 June 2018

https://api.crossref.org/works/10.1002%2F0471141755.PH0911S46

Plant antitumor agents. VI. The isolation and structure of taxol, a novel antileukemic and antitumor agent from Taxus brevifolia

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2813068

Securinine alkaloids: a new class of GABA receptor antagonist.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2813068

Display and analysis of patterns of differential activity of drugs against human tumor cell lines: development of mean graph and COMPARE algorithm.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2813068

Modular organization of genes required for complex polyketide biosynthesis

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2813068

Isolation and structure of the cell growth inhibitory constituents from the western Pacific marine sponge Axinella sp.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2813068

Identification of novel antimitotic agents acting at the tubulin level by computer-assisted evaluation of differential cytotoxicity data

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2813068

Antinutritional effects of condensed and hydrolyzable tannins

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2813068

Neural computing in cancer drug development: predicting mechanism of action

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2813068

Cocaine: History, Epidemiology, Human Pharmacology, and Treatment. A Perspective on a New Debut for an Old Girl

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2813068

Structure and action of bleomycin

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2813068

Genomic analyses lead to novel secondary metabolites. Part 3. ECO-0501, a novel antibacterial of a new class.

21 June 2018

1 reference

https://api.crossref.org/works/10.1002%2F0471141755.PH0911S46

Further Studies on Phorbol Ester Bioactivity in the Euphorbiaceae

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F0471141755.PH0911S46

From the Zulu medicine to the European phytomedicine Umckaloabo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F0471141755.PH0911S46

Natural product drug discovery: the times have never been better.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F0471141755.PH0911S46

The Synthesis of Morphine

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F0471141755.PH0911S46

bryA: an unusual modular polyketide synthase gene from the uncultivated bacterial symbiont of the marine bryozoan Bugula neritina

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F0471141755.PH0911S46

Exploring chemical diversity of epoxyquinoid natural products: synthesis and biological activity of (-)-jesterone and related molecules.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F0471141755.PH0911S46

Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F0471141755.PH0911S46

Aquaculture of three phyla of marine invertebrates to yield bioactive metabolites: process developments and economics

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F0471141755.PH0911S46

A new candidate for an anti-HIV-1 agent: modified cyclodextrin sulfate (mCDS71).

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F0471141755.PH0911S46

Marine natural products and related compounds in clinical and advanced preclinical trials

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F0471141755.PH0911S46

Natural products from marine invertebrates and microbes as modulators of antitumor targets

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F0471141755.PH0911S46

A Siphonotid Millipede (Rhinotus) as the Source of Spiropyrrolizidine Oximes of Dendrobatid Frogs

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F0471141755.PH0911S46

Structure-activity relationships of halichondrin B analogues: modifications at C.30-C.38.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F0471141755.PH0911S46

The antibiotic pipeline--challenges, costs, and values

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F0471141755.PH0911S46

The antiviral activity of SP-303, a natural polyphenolic polymer, against respiratory syncytial and parainfluenza type 3 viruses in cotton rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F0471141755.PH0911S46

Rhetoric, Realism and Benefit-Sharing

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F0471141755.PH0911S46

Ketosynthase III as a gateway to engineering the biosynthesis of antitumoral benastatin derivatives.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F0471141755.PH0911S46

Total Synthesis of Bryostatin 2

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F0471141755.PH0911S46

Protecting traditional knowledge: the San and hoodia

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2813068

Characterization of anticancer agents by their growth inhibitory activity and relationships to mechanism of action and structure.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2813068

Epibatidine, a potent analgetic and nicotinic agonist.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2813068

The Structure of Muscimol, a GABA Analogue of Restricted Conformation

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2813068

A new EGF-active polymeric pyridinium alkaloid from the sponge Callyspongia fibrosa

30 October 2018

1 reference

https://api.crossref.org/works/10.1002%2F0471141755.PH0911S46

Role of the A-ring of bryostatin analogues in PKC binding: synthesis and initial biological evaluation of new A-ring-modified bryologs

21 January 2018

1 reference

12 December 2020

Effect of tannins on screening of plant extracts for enzyme inhibitory activity and techniques for their removal

1 reference

12 December 2020

The large-scale isolation of bryostatin 1 from Bugula neritina following current good manufacturing practices

1 reference

12 December 2020

CHEMISTRY AND STRUCTURE OF MITOMYCIN C

1 reference

12 December 2020

Dereplication of phorbol bioactives: Lyngbya majuscula and Croton cuneatus

1 reference

12 December 2020

Alkaloids in the metabolism of plants

1 reference

12 December 2020

Allelopathic prenylflavanones from the fallen leaves of Macaranga tanarius

1 reference

12 December 2020

A chemical screening strategy for the dereplication and prioritization of HIV-inhibitory aqueous natural products extracts

1 reference

12 December 2020

Bicuculline Methochloride as a GABA Antagonist

1 reference

12 December 2020

Evolving trends in the dereplication of natural product extracts: new methodology for rapid, small-scale investigation of natural product extracts

1 reference

12 December 2020

Marine natural products

1 reference

12 December 2020

Marine chemical ecology

1 reference

12 December 2020

Bicuculline and picrotoxin block gamma-aminobutyric acid-gated Cl- conductance by different mechanisms

1 reference

12 December 2020

10.1002/0471141755.PH0911S46

Identifiers

DOI

1 reference

28 July 2017

1 reference

28 July 2017

1 reference