Expanded anticancer therapeutic window of hexon-modified oncolytic adenovirus (Q33622711)

28 July 2017

title

Expanded anticancer therapeutic window of hexon-modified oncolytic adenovirus (English)

1 reference

28 July 2017

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Elena V Shashkova

1

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28 July 2017

Shannon M May

series ordinal

2

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28 July 2017

Konstantin Doronin

series ordinal

3

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28 July 2017

Michael A Barry

series ordinal

4

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28 July 2017

publication date

15 September 2009

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28 July 2017

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28 July 2017

volume

17

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28 July 2017

issue

12

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28 July 2017

page(s)

2121-2130

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Chemical modification with high molecular weight polyethylene glycol reduces transduction of hepatocytes and increases efficacy of intravenously delivered oncolytic adenovirus

28 July 2017

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21 June 2018

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21 June 2018

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21 June 2018

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Macrophage depletion combined with anticoagulant therapy increases therapeutic window of systemic treatment with oncolytic adenovirus

21 June 2018

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Substitution of hexon hypervariable region 5 of adenovirus serotype 5 abrogates blood factor binding and limits gene transfer to liver

21 June 2018

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21 June 2018

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Hexadecyloxypropyl-cidofovir, CMX001, prevents adenovirus-induced mortality in a permissive, immunosuppressed animal model

21 June 2018

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Adenovirus serotype 5 hexon is critical for virus infection of hepatocytes in vivo

21 June 2018

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21 June 2018

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Anticancer activity of oncolytic adenovirus vector armed with IFN-alpha and ADP is enhanced by pharmacologically controlled expression of TRAIL

21 June 2018

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21 June 2018

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Targeted cancer gene therapy using a hypoxia inducible factor dependent oncolytic adenovirus armed with interleukin-4

21 June 2018

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21 June 2018

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21 June 2018

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Eradication of therapy-resistant human prostate tumors using a cancer terminator virus

21 June 2018

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Clinical trial results with oncolytic virotherapy: a century of promise, a decade of progress

21 June 2018

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Targeting interferon-alpha increases antitumor efficacy and reduces hepatotoxicity of E1A-mutated spread-enhanced oncolytic adenovirus

21 June 2018

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21 June 2018

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Multiple vitamin K-dependent coagulation zymogens promote adenovirus-mediated gene delivery to hepatocytes

21 June 2018

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A phase I trial of intravenous CG7870, a replication-selective, prostate-specific antigen-targeted oncolytic adenovirus, for the treatment of hormone-refractory, metastatic prostate cancer.

21 June 2018

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Second-generation replication-competent oncolytic adenovirus armed with improved suicide genes and ADP gene demonstrates greater efficacy without increased toxicity

21 June 2018

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Oncolytic adenovirus that overproduces ADP and replicates selectively in tumors due to hTERT promoter-regulated E4 gene expression

21 June 2018

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Adenovirus Binding to Blood Factors Results in Liver Cell Infection and Hepatotoxicity

21 June 2018

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Induction and inhibition of innate inflammatory responses by adenovirus early region proteins

21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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Intratumoral spread of wild-type adenovirus is limited after local injection of human xenograft tumors: virus persists and spreads systemically at late time points

21 June 2018

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Intravascular adenoviral agents in cancer patients: lessons from clinical trials

21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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Repopulation of murine Kupffer cells after intravenous administration of liposome-encapsulated dichloromethylene diphosphonate.

21 June 2018

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The adenovirus death protein (E3-11.6K) is required at very late stages of infection for efficient cell lysis and release of adenovirus from infected cells

21 June 2018

1 reference

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Transcriptional repression of interleukin-6 gene by adenoviral E1A proteins

21 June 2018

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Infection of Mouse Liver by Human Adenovirus Type 5

21 June 2018

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Adenovirus serotype 5 hexon mediates liver gene transfer

21 June 2018

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China approves world's first oncolytic virus therapy for cancer treatment

30 October 2018

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Rapid Kupffer cell death after intravenous injection of adenovirus vectors

30 October 2018

1 reference

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A hemodynamic response to intravenous adenovirus vector particles is caused by systemic Kupffer cell-mediated activation of endothelial cells

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2814381

Pharmacologic indicators of antitumor efficacy for oncolytic virotherapy

30 October 2018

1 reference

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Systemic vector leakage and transgene expression by intratumorally injected recombinant adenovirus vectors

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2814381

Sequestration of adenoviral vector by Kupffer cells leads to a nonlinear dose response of transduction in liver

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2814381

Evaluation of the biodistribution, persistence, toxicity, and potential of germ-line transmission of a replication-competent human adenovirus following intraprostatic administration in the mouse

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2814381

Innate immune mechanisms dominate elimination of adenoviral vectors following in vivo administration.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2814381

Overexpression of the ADP (E3-11.6K) protein increases cell lysis and spread of adenovirus

30 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19755961

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/MT.2009.217

1 reference

28 July 2017

1 reference

28 July 2017

1 reference