The mtDNA mutator mouse: Dissecting mitochondrial involvement in aging (Q33627941)

28 July 2017

The mtDNA mutator mouse: Dissecting mitochondrial involvement in aging (English)

1 reference

28 July 2017

Daniel Edgar

1

1 reference

PubMed ID

20157586

28 July 2017

Aleksandra Trifunovic

series ordinal

2

1 reference

28 July 2017

11 December 2009

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28 July 2017

1 reference

28 July 2017

1

1 reference

28 July 2017

12

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28 July 2017

1028-1032

1 reference

Random point mutations with major effects on protein-coding genes are the driving force behind premature aging in mtDNA mutator mice.

28 July 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2815752

Quantification of mitochondrial DNA mutation load

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2815752

Do mtDNA deletions drive premature aging in mtDNA mutator mice?

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2815752

Mice expressing an error-prone DNA polymerase in mitochondria display elevated replication pausing and chromosomal breakage at fragile sites of mitochondrial DNA.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2815752

A functionally dominant mitochondrial DNA mutation

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2815752

Strong purifying selection in transmission of mammalian mitochondrial DNA

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2815752

High levels of mitochondrial DNA deletions in substantia nigra neurons in aging and Parkinson disease

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2815752

Mutant mitochondrial helicase Twinkle causes multiple mtDNA deletions and a late-onset mitochondrial disease in mice

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2815752

Gene therapy for progeny of mito-mice carrying pathogenic mtDNA by nuclear transplantation

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2815752

Mitochondrial DNA mutations, oxidative stress, and apoptosis in mammalian aging

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2815752

Premature ageing in mice expressing defective mitochondrial DNA polymerase

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2815752

A mitochondrial paradigm for degenerative diseases and ageing

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2815752

Muscle-specific mutations accumulate with aging in critical human mtDNA control sites for replication

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2815752

Aging-dependent large accumulation of point mutations in the human mtDNA control region for replication

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2815752

Age differences in the ultrastructure of axons in the pyramidal tract of the mouse.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2815752

A pattern of accumulation of a somatic deletion of mitochondrial DNA in aging human tissues

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2815752

A Morphometric Study of Age-Dependent Changes in Mitochondrial Populations of Mouse Liver and Heart

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2815752

The transcription map of mouse mitochondrial DNA

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2815752

The Effect of Age on Mitochondrial Ultrastructure and Enzyme Cytochemistry

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2815752

Mitochondrial dysfunction as a cause of ageing

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2815752

Mitochondrial point mutations do not limit the natural lifespan of mice.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2815752

A Ginkgo biloba extract (EGb 761) prevents mitochondrial aging by protecting against oxidative stress.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2815752

DNA deletions and clonal mutations drive premature aging in mitochondrial mutator mice

30 October 2018

1 reference

12 December 2020

Generation of mice with mitochondrial dysfunction by introducing mouse mtDNA carrying a deletion into zygotes

1 reference

12 December 2020

Ageing muscle: clonal expansions of mitochondrial DNA point mutations and deletions cause focal impairment of mitochondrial function

1 reference

12 December 2020

The Effect of Age on Mitochondrial Ultrastructure

1 reference

12 December 2020

A Morphometric Study of the Density of Mitochondrial Cristae in Heart and Liver of Aging Mice

1 reference

12 December 2020

Mitochondrial DNA copy number in bovine oocytes and somatic cells

1 reference

12 December 2020

release_soxlhjbovbcqjdlixrkjc2d6wu

Identifiers

DOI

10.18632/AGING.100109

0 references

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/soxlhjbovbcqjdlixrkjc2d6wu

24 November 2022

mapped directly with Wikidata item

PMCID

2815752

1 reference

28 July 2017

1 reference

PubMed ID

20157586