Mice expressing an error-prone DNA polymerase in mitochondria display elevated replication pausing and chromosomal breakage at fragile sites of mitochondrial DNA. (Q37169833)

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scientific article published on 25 February 2009

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English	Mice expressing an error-prone DNA polymerase in mitochondria display elevated replication pausing and chromosomal breakage at fragile sites of mitochondrial DNA.	scientific article published on 25 February 2009

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22 January 2020

Mice expressing an error-prone DNA polymerase in mitochondria display elevated replication pausing and chromosomal breakage at fragile sites of mitochondrial DNA (English)

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22 January 2020

mitochondrial DNA

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5

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22 January 2020

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22 January 2020

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Laura J Bailey

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22 January 2020

Tricia J Cluett

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22 January 2020

Aurelio Reyes

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22 January 2020

Tom A Prolla

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22 January 2020

Christiaan Leeuwenburgh

6

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22 January 2020

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25 February 2009

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22 January 2020

Nucleic Acids Research

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22 January 2020

37

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22 January 2020

7

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22 January 2020

2327-2335

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22 January 2020

The mitochondrial transcription termination factor mTERF modulates replication pausing in human mitochondrial DNA

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The human Werner syndrome protein stimulates repair of oxidative DNA base damage by the DNA glycosylase NEIL1

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Replication fork barriers: pausing for a break or stalling for time?

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Replication of vertebrate mitochondrial DNA entails transient ribonucleotide incorporation throughout the lagging strand.

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High levels of mitochondrial DNA deletions in substantia nigra neurons in aging and Parkinson disease

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Discovery of a major D-loop replication origin reveals two modes of human mtDNA synthesis

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Two direct repeats cause most human mtDNA deletions

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6 September 2017

Premature ageing in mice expressing defective mitochondrial DNA polymerase

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Diseases caused by nuclear genes affecting mtDNA stability

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Characterization of the human and mouse WRN 3'-->5' exonuclease

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Coupled leading- and lagging-strand synthesis of mammalian mitochondrial DNA.

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6 September 2017

The importance of repairing stalled replication forks

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Mitochondrial mutational spectra in human cells and tissues

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The localization of replication origins on ARS plasmids in S. cerevisiae

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6 September 2017

A bidirectional origin of replication maps to the major noncoding region of human mitochondrial DNA.

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14 September 2017

The arrest of replication forks in the rDNA of yeast occurs independently of transcription

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Replication fork regression in vitro by the Werner syndrome protein (WRN): holliday junction formation, the effect of leading arm structure and a potential role for WRN exonuclease activity.

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Mitochondrial DNA deletions are abundant and cause functional impairment in aged human substantia nigra neurons.

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An autosomal dominant disorder with multiple deletions of mitochondrial DNA starting at the D-loop region

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12 December 2020

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Mitochondrial myopathies: clinical and biochemical features of 30 patients with major deletions of muscle mitochondrial DNA

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12 December 2020

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In vivo determination of replication origins of human mitochondrial DNA by ligation-mediated polymerase chain reaction

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Identifiers

10.1093/NAR/GKP091

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22 January 2020

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22 January 2020

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22 January 2020

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