Isocitrate dehydrogenase-1 mutations: a fundamentally new understanding of diffuse glioma? (Q33628344)

28 July 2017

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title

Isocitrate dehydrogenase-1 mutations: a fundamentally new understanding of diffuse glioma? (English)

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28 July 2017

Nanne K Kloosterhof

1

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28 July 2017

Linda B C Bralten

2

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28 July 2017

Hendrikus J Dubbink

3

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28 July 2017

Pim J French

4

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28 July 2017

Martin J van den Bent

5

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28 July 2017

7 July 2010

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Lancet Oncology Commission

28 July 2017

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28 July 2017

12

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28 July 2017

1

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28 July 2017

83-91

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An integrated genomic analysis of human glioblastoma multiforme

28 July 2017

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2810%2970053-X

7 January 2021

Analysis of the IDH1 codon 132 mutation in brain tumors

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2810%2970053-X

7 January 2021

IDH1 mutations are present in the majority of common adult gliomas but rare in primary glioblastomas

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2810%2970053-X

7 January 2021

IDH1 mutations are early events in the development of astrocytomas and oligodendrogliomas

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2810%2970053-X

7 January 2021

IDH1 and IDH2 mutations in gliomas

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2810%2970053-X

7 January 2021

Type and frequency of IDH1 and IDH2 mutations are related to astrocytic and oligodendroglial differentiation and age: a study of 1,010 diffuse gliomas.

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2810%2970053-X

7 January 2021

Isocitrate dehydrogenase 1 codon 132 mutation is an important prognostic biomarker in gliomas.

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2810%2970053-X

7 January 2021

Analysis of IDH1 and IDH2 mutations in Japanese glioma patients

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2810%2970053-X

7 January 2021

IDH1 mutations at residue p.R132 (IDH1(R132)) occur frequently in high-grade gliomas but not in other solid tumors

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2810%2970053-X

7 January 2021

IDH1 mutations as molecular signature and predictive factor of secondary glioblastomas

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2810%2970053-X

7 January 2021

Absence of IDH2 codon 172 mutation in common human cancers.

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2810%2970053-X

7 January 2021

Isocitrate dehydrogenase mutations are rare in pheochromocytomas and paragangliomas.

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2810%2970053-X

7 January 2021

Mutational analysis of IDH1 codon 132 in glioblastomas and other common cancers

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2810%2970053-X

7 January 2021

Recurring mutations found by sequencing an acute myeloid leukemia genome

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2810%2970053-X

7 January 2021

Intrinsic gene expression profiles of gliomas are a better predictor of survival than histology.

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2810%2970053-X

7 January 2021

Cancer-associated IDH1 mutations produce 2-hydroxyglutarate

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2810%2970053-X

7 January 2021

Glioma-derived mutations in IDH1 dominantly inhibit IDH1 catalytic activity and induce HIF-1alpha

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2810%2970053-X

7 January 2021

Characterization of R132H mutation-specific IDH1 antibody binding in brain tumors

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2810%2970053-X

7 January 2021

Monoclonal antibody specific for IDH1 R132H mutation

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2810%2970053-X

7 January 2021

Molecular predictors of progression-free and overall survival in patients with newly diagnosed glioblastoma: a prospective translational study of the German Glioma Network

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2810%2970053-X

7 January 2021

NOA-04 randomized phase III trial of sequential radiochemotherapy of anaplastic glioma with procarbazine, lomustine, and vincristine or temozolomide

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2810%2970053-X

7 January 2021

IDH1 and IDH2 mutations are prognostic but not predictive for outcome in anaplastic oligodendroglial tumors: a report of the European Organization for Research and Treatment of Cancer Brain Tumor Group

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2810%2970053-X

7 January 2021

IDH1 mutations in low-grade astrocytomas predict survival but not response to temozolomide

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2810%2970053-X

7 January 2021

Mutations of IDH1 and IDH2 are not detected in brain metastases of colorectal cancer

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2810%2970053-X

7 January 2021

Insights from retinitis pigmentosa into the roles of isocitrate dehydrogenases in the Krebs cycle

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2810%2970053-X

7 January 2021

Mutagenesis and Laue structures of enzyme intermediates: isocitrate dehydrogenase

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2810%2970053-X

7 January 2021

Distances among coenzyme and metal sites of NADP+-dependent isocitrate dehydrogenase using resonance energy transfer

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2810%2970053-X

7 January 2021

Slow Association-Dissociation Equilibrium of NADP-Linked Isocitrate Dehydrogenase from Beef Liver in Relation to Catalytic Activity

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2810%2970053-X

7 January 2021

Global cancer statistics, 2002

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2810%2970053-X

7 January 2021

Epidemiology and etiology of gliomas

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2810%2970053-X

7 January 2021

Genetic pathways to primary and secondary glioblastoma

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2810%2970053-X

7 January 2021

Genetic alterations and signaling pathways in the evolution of gliomas

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2810%2970053-X

7 January 2021

Segregation of non-p.R132H mutations in IDH1 in distinct molecular subtypes of glioma

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2810%2970053-X

7 January 2021

Combined molecular analysis of BRAF and IDH1 distinguishes pilocytic astrocytoma from diffuse astrocytoma.

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2810%2970053-X

7 January 2021

The consensus coding sequences of human breast and colorectal cancers

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2810%2970053-X

7 January 2021

Panel review of anaplastic oligodendroglioma from European Organization For Research and Treatment of Cancer Trial 26951: assessment of consensus in diagnosis, influence of 1p/19q loss, and correlations with outcome

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2810%2970053-X

7 January 2021

A monoclonal antibody IMab-1 specifically recognizes IDH1R132H, the most common glioma-derived mutation

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2810%2970053-X

7 January 2021

PCR- and restriction endonuclease-based detection of IDH1 mutations

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2810%2970053-X

7 January 2021

Patterns of somatic mutation in human cancer genomes

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2810%2970053-X

7 January 2021

Glutaric aciduria type II [corrected] and brain tumors: a case report and review of the literature

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2810%2970053-X

7 January 2021

Hydroxyglutaric aciduria and malignant brain tumor: a case report and literature review

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2810%2970053-X

7 January 2021

Crystal structure of porcine mitochondrial NADP+-dependent isocitrate dehydrogenase complexed with Mn2+ and isocitrate. Insights into the enzyme mechanism

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2810%2970053-X

7 January 2021

Expression and mutagenesis of mammalian cytosolic NADP+-specific isocitrate dehydrogenase

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2810%2970053-X

7 January 2021

Identification by mutagenesis of arginines in the substrate binding site of the porcine NADP-dependent isocitrate dehydrogenase

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2810%2970053-X

7 January 2021

Selective acquisition of IDH1 R132C mutations in astrocytomas associated with Li-Fraumeni syndrome

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2810%2970053-X

7 January 2021

Evaluation by mutagenesis of the roles of His309, His315, and His319 in the coenzyme site of pig heart NADP-dependent isocitrate dehydrogenase

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2810%2970053-X

7 January 2021

Ligands of the Mn2+ bound to porcine mitochondrial NADP-dependent isocitrate dehydrogenase, as assessed by mutagenesis

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2810%2970053-X

7 January 2021

Implication by site-directed mutagenesis of Arg314 and Tyr316 in the coenzyme site of pig mitochondrial NADP-dependent isocitrate dehydrogenase

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2810%2970053-X

7 January 2021

Ser95, Asn97, and Thr78 are important for the catalytic function of porcine NADP-dependent isocitrate dehydrogenase

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2810%2970053-X

7 January 2021

High frequency of mutations of the PIK3CA gene in human cancers

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2810%2970053-X

7 January 2021

Structural basis for a change in substrate specificity: crystal structure of S113E isocitrate dehydrogenase in a complex with isopropylmalate, Mg2+, and NADP

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2810%2970053-X

7 January 2021

Redesigning the substrate specificity of an enzyme: isocitrate dehydrogenase

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2810%2970053-X

7 January 2021

L: -2-Hydroxyglutaric aciduria, a disorder of metabolite repair

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2810%2970053-X

7 January 2021

NMDA receptor activation and respiratory chain complex V inhibition contribute to neurodegeneration in d-2-hydroxyglutaric aciduria

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2810%2970053-X

7 January 2021

Mitochondria in cancer: not just innocent bystanders

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2810%2970053-X

7 January 2021

An immunohistochemical procedure to detect patients with paraganglioma and phaeochromocytoma with germline SDHB, SDHC, or SDHD gene mutations: a retrospective and prospective analysis

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2810%2970053-X

7 January 2021

Quantifying interactions within the NADP(H) enzyme network in Drosophila melanogaster

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2810%2970053-X

7 January 2021

IDH1 gene transcription is sterol regulated and activated by SREBP-1a and SREBP-2 in human hepatoma HepG2 cells: evidence that IDH1 may regulate lipogenesis in hepatic cells

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2810%2970053-X

7 January 2021

Cytosolic NADP+-dependent isocitrate dehydrogenase plays a key role in lipid metabolism

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2810%2970053-X

7 January 2021

Relationship of the oxidative pentose shunt pathway to lipid synthesis in Drosophila melanogaster

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2810%2970053-X

7 January 2021

A pyruvate cycling pathway involving cytosolic NADP-dependent isocitrate dehydrogenase regulates glucose-stimulated insulin secretion

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2810%2970053-X

7 January 2021

Metabolic enzymes as oncogenes or tumor suppressors

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2810%2970053-X

7 January 2021

Role of cytosolic NADP+-dependent isocitrate dehydrogenase in ischemia-reperfusion injury in mouse kidney

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2810%2970053-X

7 January 2021

Small interfering RNA-mediated silencing of mitochondrial NADP+-dependent isocitrate dehydrogenase enhances the sensitivity of HeLa cells toward tumor necrosis factor-alpha and anticancer drugs

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2810%2970053-X

7 January 2021

Regulation of ethanol-induced toxicity by mitochondrial NADP(+)-dependent isocitrate dehydrogenase

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2810%2970053-X

7 January 2021

Regulation of ionizing radiation-induced apoptosis by mitochondrial NADP+-dependent isocitrate dehydrogenase.

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2810%2970053-X

7 January 2021

A hypermutation phenotype and somatic MSH6 mutations in recurrent human malignant gliomas after alkylator chemotherapy.

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2810%2970053-X

7 January 2021

Testicular gene expression in male mice divergent for fertility after heat stress

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2810%2970053-X

7 January 2021

Gene expression of AGS cells stimulated with released proteins by Helicobacter pylori

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2810%2970053-X

7 January 2021

Lactate promotes glioma migration by TGF-beta2-dependent regulation of matrix metalloproteinase-2.

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2810%2970053-X

7 January 2021

Neuronal apoptosis by prolyl hydroxylation: implication in nervous system tumours and the Warburg conundrum

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2810%2970053-X

7 January 2021

Antitumor effects of 2-oxoglutarate through inhibition of angiogenesis in a murine tumor model

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2810%2970053-X

7 January 2021

Neuronal apoptosis linked to EglN3 prolyl hydroxylase and familial pheochromocytoma genes: developmental culling and cancer

1 reference

https://api.crossref.org/works/10.1016%2FS1470-2045%2810%2970053-X

7 January 2021

10.1016/S1470-2045(10)70053-X

Identifiers

DOI

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28 July 2017

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