A hypermutation phenotype and somatic MSH6 mutations in recurrent human malignant gliomas after alkylator chemotherapy. (Q48582050)

13 February 2018

title

A hypermutation phenotype and somatic MSH6 mutations in recurrent human malignant gliomas after alkylator chemotherapy. (English)

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13 February 2018

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Christopher I. Hunter

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Kristian Gray

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Andy Jenkinson

Andy Jenkinson

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Andrew D Yates

Andy Yates

45

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David Richardson

David Richardson

37

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Sarah Edkins

Sarah Edkins

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P. Andrew Futreal

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P Andrew Futreal

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Douglas F Easton

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Gemma Buck

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Keiran Raine

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Keiran Raine

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Andrew Menzies

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Jon Teague

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Michael R Stratton

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Richard Wooster

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David R. Jones

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David Jones

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Helen Davies

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Helen Davies

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Tim Avis

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Tim Avis

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Sofie West

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Sofie West

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Syd Barthorpe

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Syd Barthorpe

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Kymberly K Levine

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Kymberly K Levine

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Kelly Halliday

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Kelly Halliday

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Lisa Brackenbury

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Lisa Brackenbury

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Richard Lugg

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Richard Lugg

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Raffaella Smith

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Raffaella Smith

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Alexandra Small

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Alexandra Small

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Jonathon Hinton

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Jonathon Hinton

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Ross Laman

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Ross Laman

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Jennifer Varian

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Jennifer Varian

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Calli Tofts

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Calli Tofts

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Sarah O'Meara

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Sarah O'Meara

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Vivienne Kosmidou

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Vivienne Kosmidou

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author name string

Daniel P Cahill

3

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Philip Stephens

4

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Claire Stevens

5

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Chris Greenman

7

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Graham Bignell

9

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Adrian Parker

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Adam Butler

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Jody Clements

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Jennifer Cole

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Ed Dicks

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Simon Forbes

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Matthew Gorton

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Rachel Harrison

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Katy Hills

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Janet Perry

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Robert Petty

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Rebecca Shepherd

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Helen Solomon

40

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Sara Widaa

44

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Gregory Riggins

47

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Jennifer E Roy

48

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Wolf Mueller

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Tracy T Batchelor

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David N Louis

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language of work or name

English

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publication date

1 April 2006

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13 February 2018

published in

Cancer Research

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13 February 2018

volume

66

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issue

8

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13 February 2018

page(s)

3987-3991

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Inactivation of the DNA repair gene O6-methylguanine-DNA methyltransferase by promoter hypermethylation is a common event in primary human neoplasia

cites work

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12 December 2020

High-resolution analysis of DNA copy number using oligonucleotide microarrays

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12 December 2020

CDK inhibitors: positive and negative regulators of G1-phase progression

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12 December 2020

A homozygous mutation in MSH6 causes Turcot syndrome.

1 reference

12 December 2020

Spectra of spontaneous mutations at the hprt locus in colorectal carcinoma cell lines defective in mismatch repair.

1 reference

12 December 2020

The role of DNA mismatch repair in drug resistance.

1 reference

12 December 2020

A screen of the complete protein kinase gene family identifies diverse patterns of somatic mutations in human breast cancer.

1 reference

12 December 2020

Tissues of MSH2-deficient mice demonstrate hypermutability on exposure to a DNA methylating agent.

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12 December 2020

Amplified genes in human gliomas.

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12 December 2020

Adjuvant chemotherapy in the treatment of high grade gliomas.

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12 December 2020

Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma

1 reference

12 December 2020

Somatic mutations of the protein kinase gene family in human lung cancer

1 reference

12 December 2020

Mismatch repair deficient human cells: spontaneous and MNNG-induced mutational spectra in the HPRT gene

1 reference

12 December 2020

MGMT gene silencing and benefit from temozolomide in glioblastoma

1 reference

12 December 2020

Dependence of the cytotoxicity of DNA-damaging agents on the mismatch repair status of human cells

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12 December 2020

Role of DNA mismatch repair and p53 in signaling induction of apoptosis by alkylating agents.

1 reference

12 December 2020

Sequence survey of receptor tyrosine kinases reveals mutations in glioblastomas

1 reference

12 December 2020

A homozygous MSH6 mutation in a child with café-au-lait spots, oligodendroglioma and rectal cancer

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12 December 2020

Human mismatch repair, drug-induced DNA damage, and secondary cancer.

1 reference

12 December 2020

Sequence analysis of the protein kinase gene family in human testicular germ-cell tumors of adolescents and adults

1 reference

12 December 2020

Elevated mutant frequencies and predominance of G:C to A:T transition mutations in Msh6(-/-) small intestinal epithelium

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12 December 2020

10.1158/0008-5472.CAN-06-0127

Identifiers

DOI

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13 February 2018

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13 February 2018