Chirality and drugs used in psychiatry: nice to know or need to know? (Q33630484)

28 July 2017

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title

Chirality and drugs used in psychiatry: nice to know or need to know? (English)

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28 July 2017

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Lane RM

1

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28 July 2017

Baker GB

series ordinal

2

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28 July 2017

publication date

1 June 1999

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Cellular and Molecular Neurobiology

28 July 2017

published in

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28 July 2017

volume

19

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28 July 2017

issue

3

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28 July 2017

page(s)

355-372

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Mapping human brain monoamine oxidase A and B with 11C-labeled suicide inactivators and PET

28 July 2017

cites work

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12 December 2020

Chirality in new drug development. Clinical pharmacokinetic considerations

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12 December 2020

Doxepin up-to-date: a review of its pharmacological properties and therapeutic efficacy with particular reference to depression

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12 December 2020

Pharmacokinetics and Biological Effects of Nortriptyline in Man

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12 December 2020

Steady-state pharmacokinetics of the enantiomers of citalopram and its metabolites in humans

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12 December 2020

Diastereoisomeric glucuronides of oxazepam. Isolation and stereoselective enzymic hydrolysis

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12 December 2020

Enantioselective formation and disposition of (E)- and (Z)-10-hydroxynortriptyline

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12 December 2020

Determination of citalopram enantiomers in human plasma by liquid chromatographic separation on a Chiral-AGP column

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12 December 2020

Stereoselective interaction of mianserin with 5-HT3 receptors

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12 December 2020

Enantiospecific analysis: applications in bioanalysis and metabolism

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12 December 2020

Preparative and analytical separation of the zopiclone enantiomers and determination of their affinity to the benzodiazepine receptor binding site.

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12 December 2020

Comparative pharmacokinetics of selective serotonin reuptake inhibitors: a look behind the mirror.

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12 December 2020

Chiral separations by capillary electrophoresis: present state of the art.

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12 December 2020

Stereoselective disposition of mianserin is related to debrisoquin hydroxylation polymorphism

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12 December 2020

The pharmacological effect of citalopram residues in the (S)-(+)-enantiomer

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12 December 2020

Identification of human cytochrome P450 isoforms involved in the stereoselective metabolism of mianserin enantiomers

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12 December 2020

Determination of the enantiomers of zopiclone and its two chiral metabolites in urine using an automated coupled achiral-chiral chromatographic system

1 reference

12 December 2020

The effect of (±)mianserin and its enantiomers on the behavioural hyperactivity of the olfactory-bulbectomized rat

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12 December 2020

High stereospecificity of the benzodiazepine binding site on human serum albumin. Studies with d- and l-oxazepam hemisuccinate

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12 December 2020

Bioequivalence of racemic drugs

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12 December 2020

Alpha 2-adrenoceptors in rat hypothalamus and cerebral cortex: functional evidence for pharmacologically distinct subpopulations

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12 December 2020

Bioequivalence of chiral drugs. Stereospecific versus non-stereospecific methods

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12 December 2020

Plasma levels of the enantiomers of thioridazine, thioridazine 2-sulfoxide, thioridazine 2-sulfone, and thioridazine 5-sulfoxide in poor and extensive metabolizers of dextromethorphan and mephenytoin.

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12 December 2020

Norfluoxetine enantiomers as inhibitors of serotonin uptake in rat brain

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12 December 2020

The pharmacokinetics of tranylcypromine enantiomers in healthy subjects after oral administration of racemic drug and the single enantiomers

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12 December 2020

Tranylcypromine isomers in the treatment of Parkinson's disease. Biochemical effects

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12 December 2020

The disposition of bupropion and its metabolites in healthy male volunteers after single and multiple doses

1 reference

12 December 2020

Glucuronidation of the enantiomers of E-10-hydroxynortriptyline in human and rat liver microsomes

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12 December 2020

Glucuronides of hydroxylated metabolites of amitriptyline and nortriptyline isolated from rat bile.

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12 December 2020

Stereoselectivity in clinical pharmacokinetics and drug development

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12 December 2020

The Disposition and Metabolism of I.C.I. 58,834 (Viloxazine) in Humans

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12 December 2020

Pharmacokinetics of bupropion and its major basic metabolites in normal subjects after a single dose

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12 December 2020

In vivo and in vitro stereoselective metabolism of mianserin in mice

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12 December 2020

Current regulatory (draft) guidance on chiral medicinal products: Canada, EEC, Japan, United States

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12 December 2020

Cis- and trans-isomers of doxepin and desmethyldoxepin in the plasma of depressed patients treated with doxepin.

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12 December 2020

Stereoselective drug disposition: potential for misinterpretation of drug disposition data.

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12 December 2020

Enantiomeric aspects of the metabolism of mianserin in rats

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12 December 2020

Stereochemistry, a basis for sophisticated nonsense in pharmacokinetics and clinical pharmacology

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12 December 2020

The effects of desipramine and iprindole on levels of enantiomers of fluoxetine in rat brain and urine

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12 December 2020

Enantioselective pharmacodynamics and pharmacokinetics of chiral non-steroidal anti-inflammatory drugs

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12 December 2020

Comparison of the effects of mianserin and its enantiomers and metabolites on a behavioral screen for antidepressant activity

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12 December 2020

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12 December 2020

Importance of stereospecific bioanalytical monitoring in drug development

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12 December 2020

Relapse in patients on long-term fluoxetine treatment: response to increased fluoxetine dose

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12 December 2020

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12 December 2020

Prozac (fluoxetine, Lilly 110140), the first selective serotonin uptake inhibitor and an antidepressant drug: twenty years since its first publication

1 reference

12 December 2020

Chirality. Clinical pharmacokinetic and pharmacodynamic considerations

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12 December 2020

Enantiospecific high-performance liquid chromatographic assay with fluorescence detection for the monoamine oxidase inhibitor tranylcypromine and its applicability in pharmacokinetic studies

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12 December 2020

Stereospecific reversal of stress-induced anhedonia by mianserin and its (+)-enantiomer.

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12 December 2020

Enantioselective determination of mianserin and its desmethyl metabolite in plasma during treatment of depressed Japanese patients

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12 December 2020

Determination of the enantiomers of mianserin, desmethylmianserin, and 8-hydroxymianserin in the plasma and urine of mianserin-treated patients

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12 December 2020

Atypical metabolism of deprenyl and its enantiomer, (S)-(+)-N,alpha-dimethyl-N-propynylphenethylamine, by cytochrome P450 2D6.

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12 December 2020

Circular dichroism and gel filtration study of binding of prochiral and chiral 1,4-benzodiazepin-2-ones to human serum albumin

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12 December 2020

Distribution and metabolism of doxepin

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12 December 2020

Implications of chirality and geometric isomerism in some psychoactive drugs and their metabolites

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12 December 2020

Comparison of the apparent antidepressant activity of (-) and (+) tranylcypromine in an animal model

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12 December 2020

Clinical pharmacokinetics of citalopram and other selective serotonergic reuptake inhibitors (SSRI)

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12 December 2020

Receptor affinity, neurochemistry and behavioral characteristics of the enantiomers of thioridazine: evidence for different stereoselectivities at D1 and D2 receptors in rat brain

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12 December 2020

Pharmacodynamic and pharmacokinetic differences between drug enantiomers in humans: an overview

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12 December 2020

Differences in presynaptic ?-blockade, noradrenaline uptake inhibition, and potential antidepressant activity between (+)- and (-)mianserin

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12 December 2020

Stereoselective and isozyme-selective drug interactions

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12 December 2020

Pharmacological aspects of mianserin.

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12 December 2020

Quantitative GLC determination of cis- and trans-isomers of doxepin and desmethyldoxepin

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12 December 2020

5-Hydroxytryptamine2 and beta-adrenergic receptor regulation in rat brain following chronic treatment with desipramine and fluoxetine alone and in combination.

1 reference

12 December 2020

Problems in therapeutic drug monitoring: the dilemma of enantiomeric drugs in man.

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12 December 2020

Mianserin: a decade of scientific development

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12 December 2020

Pharmacokinetic aspects of deprenyl effects

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12 December 2020

Trimipramine: twenty years' worldwide clinical experience

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12 December 2020

Comparative pharmacological analysis of the optical isomers of phenyl-isopropyl-methyl-propinylamine (E-250)

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12 December 2020

Drug chirality and its clinical significance

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12 December 2020

Metabolic enantiomeric interactions: the inhibition of human (S)-warfarin-7-hydroxylase by (R)-warfarin

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12 December 2020

Enantiomeric derivatization for biomedical chromatography

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12 December 2020

Interaction between enantiomers of mianserin and ORG3770 at 5-HT3 receptors in cultured mouse neuroblastoma cells

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12 December 2020

Pharmacokinetics of zopiclone and its enantiomers in Caucasian young healthy volunteers.

1 reference

12 December 2020

Analysis of enantiomers of citalopram and its demethylated metabolites in plasma of depressive patients using chiral reverse-phase liquid chromatography

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12 December 2020

Simultaneous determination of plasma levels of fluvoxamine and of the enantiomers of fluoxetine and norfluoxetine by gas chromatography-mass spectrometry

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12 December 2020

Effect of trimipramine on depolarization-induced and Na+-Ca2+ exchange-induced 45calcium uptake in synaptosomes from the cortex of the rat brain

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12 December 2020

Determination of thioridazine enantiomers in human serum by sequential achiral and chiral high-performance liquid chromatography

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12 December 2020

Plasma levels of trimipramine and metabolites in four patients: determination of the enantiomer concentrations of the hydroxy metabolites

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12 December 2020

Pronounced inhibition of noradrenaline uptake by 10-hydroxymetabolites of nortriptyline

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12 December 2020

Functional evidence for two stereochemically different alpha-2 adrenoceptors regulating central norepinephrine and serotonin release

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12 December 2020

Recent developments in hepatic drug oxidation. Implications for clinical pharmacokinetics

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12 December 2020

Progress in the separation of enantiomers of chiral drugs by TLC without their prior derivatization.

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12 December 2020

Pharmacokinetics of second generation antidepressants: bupropion

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12 December 2020

Deprenyl is metabolized to methamphetamine and amphetamine in man

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12 December 2020

Absence of stereoselectivity of some tricyclic antidepressants for the inhibition of depolarization-induced calcium uptake in rat cingulate cortex synaptosomes.

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12 December 2020

Clinical pharmacokinetics of selective serotonin reuptake inhibitors

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12 December 2020

Stereoselective blockade of central [3H]5-hydroxytryptamine binding to multiple sites (5-HT1A, 5-HT1B and 5-HT1C) by mianserin and propranolol

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12 December 2020

The use of thioproperazine, a phenothiazine derivative, as a ligand for neuroleptic receptors—II

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12 December 2020

Pharmacologic profile and efficacy of venlafaxine.

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12 December 2020

Venlafaxine oxidation in vitro is catalysed by CYP2D6.

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12 December 2020

Simultaneous determination of fluoxetine and norfluoxetine enantiomers in biological samples by gas chromatography with electron-capture detection

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12 December 2020

Gas chromatographic determination of enantiomers as diastereomers following pre-column derivatization and applications to pharmacokinetic studies: a review

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12 December 2020

Active hydroxymetabolites of antidepressants. Emphasis on E-10-hydroxy-nortriptyline

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12 December 2020

Enantioselective aspects of drug action and disposition: therapeutic pitfalls

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12 December 2020

Plasma levels of thioridazine and metabolites are influenced by the debrisoquin hydroxylation phenotype

1 reference

12 December 2020

Pharmacokinetic and pharmacodynamic consequences of stereoselective drug metabolism in man.

1 reference

12 December 2020

Fluvoxamine. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in depressive illness

1 reference

12 December 2020

Trimipramine: Pharmacological reevaluation and comparison with clozapine

1 reference

12 December 2020

Steric requirements for catecholamine uptake by rat brain synaptosomes: studies with rigid analogs of amphetamine.

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12 December 2020

Enantiomer specific pharmacokinetics

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12 December 2020

Fluoxetine and its two enantiomers as selective serotonin uptake inhibitors

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12 December 2020

The potential therapeutic role of the enantiomers and metabolites of mianserin

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12 December 2020

Stereoselective pharmacokinetics of doxepin isomers

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12 December 2020

Enantioselective determination of zopiclone and its metabolites in urine by capillary electrophoresis

1 reference

12 December 2020

A comparison of the neurochemical properties of the stereoisomers of tranylcypromine in the central nervous system

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12 December 2020

Interaction of the enantiomers of fluoxetine and norfluoxetine with human liver cytochromes P450

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12 December 2020

Pharmacology of selegiline

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12 December 2020

Adrenoreceptor interactions of the enantiomers and metabolites of mianserin: are they responsible for the antidepressant effect?

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12 December 2020

Racemization kinetics of enantiomeric oxazepams and stereoselective hydrolysis of enantiomeric oxazepam 3-acetates in rat liver microsomes and brain homogenate

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12 December 2020

Critical issues in chiral drug analysis in biological fluids by high-performance liquid chromatography

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12 December 2020

Comparison of norfluoxetine enantiomers as serotonin uptake inhibitors in vivo

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12 December 2020

The importance of stereochemistry in drug action and disposition

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12 December 2020

Identifiers

DOI

10.1023/A:1006997731966

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Dimensions Publication ID

28 July 2017

1025166044

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