From computer simulations to human disease: emerging themes in protein folding (Q33630957)

28 July 2017

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title

From computer simulations to human disease: emerging themes in protein folding (English)

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28 July 2017

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1

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28 July 2017

C M Dobson

2

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PubMed ID

10319810

28 July 2017

language of work or name

English

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publication date

1 April 1999

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28 July 2017

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28 July 2017

97

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28 July 2017

291-298

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28 July 2017

3

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Principles that govern the folding of protein chains

28 July 2017

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https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980739-4

7 January 2021

Formation and stability of beta-hairpin structures in polypeptides

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https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980739-4

7 January 2021

Funnels, pathways, and the energy landscape of protein folding: a synthesis

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https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980739-4

7 January 2021

The Hsp70 and Hsp60 chaperone machines

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https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980739-4

7 January 2021

Thermodynamic stability of wild-type and mutant p53 core domain

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980739-4

7 January 2021

The energy landscape of a fast-folding protein mapped by Ala-->Gly substitutions

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https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980739-4

7 January 2021

Kinetic studies of beta-sheet protein folding

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980739-4

7 January 2021

The Greek key protein apo-pseudoazurin folds through an obligate on-pathway intermediate.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980739-4

7 January 2021

Submillisecond protein folding kinetics studied by ultrarapid mixing

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https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980739-4

7 January 2021

Designing conditions for in vitro formation of amyloid protofilaments and fibrils

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https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980739-4

7 January 2021

Pathologic conformations of prion proteins.

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https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980739-4

7 January 2021

Reversible peptide folding in solution by molecular dynamics simulation.

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https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980739-4

7 January 2021

From Levinthal to pathways to funnels

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https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980739-4

7 January 2021

The fundamentals of protein folding: bringing together theory and experiment

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https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980739-4

7 January 2021

Understanding how proteins fold: the lysozyme story so far.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980739-4

7 January 2021

Protein Folding: A Perspective from Theory and Experiment.

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https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980739-4

7 January 2021

Pathways to a protein folding intermediate observed in a 1-microsecond simulation in aqueous solution

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980739-4

7 January 2021

Principles of protein folding in the cellular environment

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980739-4

7 January 2021

Nucleation mechanisms in protein folding

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https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980739-4

7 January 2021

Important role of hydrogen bonds in the structurally polarized transition state for folding of the src SH3 domain

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980739-4

7 January 2021

Diffusion-limited contact formation in unfolded cytochrome c: estimating the maximum rate of protein folding

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980739-4

7 January 2021

High-resolution protein design with backbone freedom

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https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980739-4

7 January 2021

Cryo-electron microscopy structure of an SH3 amyloid fibril and model of the molecular packing

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https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980739-4

7 January 2021

The Levinthal paradox: yesterday and today

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980739-4

7 January 2021

The alternative conformations of amyloidogenic proteins and their multi-step assembly pathways

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980739-4

7 January 2021

Design of a 20-amino acid, three-stranded beta-sheet protein.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980739-4

7 January 2021

Synergy between simulation and experiment in describing the energy landscape of protein folding

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980739-4

7 January 2021

"New view" of protein folding reconciled with the old through multiple unfolding simulations.

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https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980739-4

7 January 2021

Are there pathways for protein folding?

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https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980739-4

7 January 2021

Obligatory steps in protein folding and the conformational diversity of the transition state

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980739-4

7 January 2021

Mutually compensatory mutations during evolution of the tetramerization domain of tumor suppressor p53 lead to impaired hetero-oligomerization

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980739-4

7 January 2021

What makes a protein a protein? Hydrophobic core designs that specify stability and structural properties

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980739-4

7 January 2021

Semirational design of active tumor suppressor p53 DNA binding domain with enhanced stability

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980739-4

7 January 2021

An early intermediate in the folding reaction of the B1 domain of protein G contains a native-like core

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980739-4

7 January 2021

Time-resolved biophysical methods in the study of protein folding

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980739-4

7 January 2021

Theoretical studies of protein-folding thermodynamics and kinetics

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980739-4

7 January 2021

Conserved residues and the mechanism of protein folding

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980739-4

7 January 2021

Evidence for barrier-limited protein folding kinetics on the microsecond time scale

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https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980739-4

7 January 2021

Different folding transition states may result in the same native structure

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https://api.crossref.org/works/10.1016%2FS0092-8674%2800%2980739-4

7 January 2021

10.1016/S0092-8674(00)80739-4

Identifiers

DOI

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28 July 2017

1 reference

PubMed ID

10319810