The fundamentals of protein folding: bringing together theory and experiment (Q33536629)

27 July 2017

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title

The fundamentals of protein folding: bringing together theory and experiment (English)

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27 July 2017

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1

Dobson CM

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27 July 2017

2

Karplus M

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PubMed ID

10047588

27 July 2017

language of work or name

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1 February 1999

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Current Opinion in Structural Biology

27 July 2017

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27 July 2017

9

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27 July 2017

1

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27 July 2017

92-101

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Principles that govern the folding of protein chains

27 July 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2899%2980012-8

7 January 2021

The Levinthal paradox: yesterday and today

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2899%2980012-8

7 January 2021

Are there pathways for protein folding?

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2899%2980012-8

7 January 2021

Matching speed and stability

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2899%2980012-8

7 January 2021

Funnels, pathways, and the energy landscape of protein folding: a synthesis

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2899%2980012-8

7 January 2021

From Levinthal to pathways to funnels

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https://api.crossref.org/works/10.1016%2FS0959-440X%2899%2980012-8

7 January 2021

Protein Folding: A Perspective from Theory and Experiment.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2899%2980012-8

7 January 2021

The concept of a random coil. Residual structure in peptides and denatured proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2899%2980012-8

7 January 2021

Kinetics of protein folding. A lattice model study of the requirements for folding to the native state.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2899%2980012-8

7 January 2021

Bipartite structure of the alpha-lactalbumin molten globule

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2899%2980012-8

7 January 2021

Protein design by binary patterning of polar and nonpolar amino acids

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2899%2980012-8

7 January 2021

Nucleation mechanisms in protein folding

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2899%2980012-8

7 January 2021

Theoretical studies of protein-folding thermodynamics and kinetics

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2899%2980012-8

7 January 2021

Protein folding in the landscape perspective: chevron plots and non-Arrhenius kinetics

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2899%2980012-8

7 January 2021

Conserved residues and the mechanism of protein folding

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https://api.crossref.org/works/10.1016%2FS0959-440X%2899%2980012-8

7 January 2021

How evolution makes proteins fold quickly

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2899%2980012-8

7 January 2021

Contact order, transition state placement and the refolding rates of single domain proteins.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2899%2980012-8

7 January 2021

The folding mechanism of larger model proteins: role of native structure

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2899%2980012-8

7 January 2021

Protein folding and protein evolution: common folding nucleus in different subfamilies of c-type cytochromes?

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2899%2980012-8

7 January 2021

Understanding how proteins fold: the lysozyme story so far.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2899%2980012-8

7 January 2021

Protein folding funnels: the nature of the transition state ensemble

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2899%2980012-8

7 January 2021

"New view" of protein folding reconciled with the old through multiple unfolding simulations.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2899%2980012-8

7 January 2021

The energy landscape of a fast-folding protein mapped by Ala-->Gly substitutions

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2899%2980012-8

7 January 2021

Protein folding dynamics: quantitative comparison between theory and experiment

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2899%2980012-8

7 January 2021

Obligatory steps in protein folding and the conformational diversity of the transition state

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2899%2980012-8

7 January 2021

Important role of hydrogen bonds in the structurally polarized transition state for folding of the src SH3 domain

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2899%2980012-8

7 January 2021

Fast events in protein folding: the time evolution of primary processes

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2899%2980012-8

7 January 2021

A continuous-flow capillary mixing method to monitor reactions on the microsecond time scale.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2899%2980012-8

7 January 2021

Submillisecond events in protein folding

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2899%2980012-8

7 January 2021

Fast events in protein folding initiated by nanosecond laser photolysis

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2899%2980012-8

7 January 2021

Protein Folding Triggered by Electron Transfer

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2899%2980012-8

7 January 2021

Diffusion-limited contact formation in unfolded cytochrome c: estimating the maximum rate of protein folding

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2899%2980012-8

7 January 2021

Evidence for barrier-limited protein folding kinetics on the microsecond time scale

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2899%2980012-8

7 January 2021

Fast events in protein folding

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2899%2980012-8

7 January 2021

Time-resolved biophysical methods in the study of protein folding

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2899%2980012-8

7 January 2021

Equilibrium NMR studies of unfolded and partially folded proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2899%2980012-8

7 January 2021

Kinetic studies of protein folding using NMR spectroscopy.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2899%2980012-8

7 January 2021

Structural and dynamic characterization of partially folded states of apomyoglobin and implications for protein folding

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2899%2980012-8

7 January 2021

A residue-specific NMR view of the non-cooperative unfolding of a molten globule

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2899%2980012-8

7 January 2021

Characterization of long-range structure in the denatured state of staphylococcal nuclease. II. Distance restraints from paramagnetic relaxation and calculation of an ensemble of structures

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2899%2980012-8

7 January 2021

Structural and dynamic changes of photoactive yellow protein during its photocycle in solution

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2899%2980012-8

7 January 2021

Folding-unfolding transitions in single titin molecules characterized with laser tweezers.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2899%2980012-8

7 January 2021

Unfolding of titin immunoglobulin domains by steered molecular dynamics simulation

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2899%2980012-8

7 January 2021

Forced unfolding of fibronectin type 3 modules: an analysis by biased molecular dynamics simulations

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2899%2980012-8

7 January 2021

Theoretical studies of protein folding and unfolding

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2899%2980012-8

7 January 2021

Identification and characterization of the unfolding transition state of chymotrypsin inhibitor 2 by molecular dynamics simulations

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2899%2980012-8

7 January 2021

Characterization of the transition state of protein unfolding by use of molecular dynamics: chymotrypsin inhibitor 2

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2899%2980012-8

7 January 2021

Single versus parallel pathways of protein folding and fractional formation of structure in the transition state

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2899%2980012-8

7 January 2021

The Structure of the Transition State for Folding of Chymotrypsin Inhibitor 2 Analysed by Protein Engineering Methods: Evidence for a Nucleation-condensation Mechanism for Protein Folding

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2899%2980012-8

7 January 2021

Synergy between simulation and experiment in describing the energy landscape of protein folding

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2899%2980012-8

7 January 2021

Acid and thermal denaturation of barnase investigated by molecular dynamics simulations

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2899%2980012-8

7 January 2021

Molecular dynamics simulations of the unfolding of barnase in water and 8 M aqueous urea

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2899%2980012-8

7 January 2021

A structural basis for the interaction of urea with lysozyme

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2899%2980012-8

7 January 2021

First-principles calculation of the folding free energy of a three-helix bundle protein

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2899%2980012-8

7 January 2021

Exploring the folding free energy surface of a three-helix bundle protein

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2899%2980012-8

7 January 2021

Molecular picture of folding of a small alpha/beta protein

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2899%2980012-8

7 January 2021

Folding thermodynamics of a model three-helix-bundle protein.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2899%2980012-8

7 January 2021

Protein folding dynamics: the diffusion-collision model and experimental data

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2899%2980012-8

7 January 2021

Reversible peptide folding in solution by molecular dynamics simulation.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2899%2980012-8

7 January 2021

Solution conformations and thermodynamics of structured peptides: molecular dynamics simulation with an implicit solvation model.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2899%2980012-8

7 January 2021

A glimpse of the Holy Grail?

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2899%2980012-8

7 January 2021

Pathways to a protein folding intermediate observed in a 1-microsecond simulation in aqueous solution

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2899%2980012-8

7 January 2021

Defective protein folding as a basis of human disease

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2899%2980012-8

7 January 2021

Cell biology. The importance of being unfolded.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2899%2980012-8

7 January 2021

On the nucleation and growth of amyloid beta-protein fibrils: detection of nuclei and quantitation of rate constants

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2899%2980012-8

7 January 2021

In vivo observation of polypeptide flux through the bacterial chaperonin system.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2899%2980012-8

7 January 2021

The alternative conformations of amyloidogenic proteins and their multi-step assembly pathways

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2899%2980012-8

7 January 2021

Amyloid fibril formation by an SH3 domain

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2899%2980012-8

7 January 2021

Protein aggregation: folding aggregates, inclusion bodies and amyloid

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2899%2980012-8

7 January 2021

The structure of amyloid fibrils by electron microscopy and X-ray diffraction

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2899%2980012-8

7 January 2021

Designing conditions for in vitro formation of amyloid protofilaments and fibrils

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2899%2980012-8

7 January 2021

Cryo-electron microscopy structure of an SH3 amyloid fibril and model of the molecular packing

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2899%2980012-8

7 January 2021

Models of amyloid seeding in Alzheimer's disease and scrapie: mechanistic truths and physiological consequences of the time-dependent solubility of amyloid proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2899%2980012-8

7 January 2021

Prion diseases and the BSE crisis

1 reference

https://api.crossref.org/works/10.1016%2FS0959-440X%2899%2980012-8

7 January 2021

10.1016/S0959-440X(99)80012-8

Identifiers

DOI

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27 July 2017

1 reference

PubMed ID

10047588