Genetic-induced variations in the GAD65 T-cell repertoire governs efficacy of anti-CD3/GAD65 combination therapy in new-onset type 1 diabetes (Q33636716)

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English	Genetic-induced variations in the GAD65 T-cell repertoire governs efficacy of anti-CD3/GAD65 combination therapy in new-onset type 1 diabetes	scientific article

Statements

scholarly article

1 reference

Europe PubMed Central

28 July 2017

Genetic-induced variations in the GAD65 T-cell repertoire governs efficacy of anti-CD3/GAD65 combination therapy in new-onset type 1 diabetes (English)

1 reference

Europe PubMed Central

28 July 2017

type-1 diabetes

0 references

Matthias von Herrath

5

object named as

Matthias von Herrath

1 reference

Europe PubMed Central

28 July 2017

author name string

Damien Bresson

1

1 reference

Europe PubMed Central

28 July 2017

Matthew Fradkin

2

1 reference

Europe PubMed Central

28 July 2017

Yulia Manenkova

3

1 reference

Europe PubMed Central

28 July 2017

Diane Rottembourg

4

1 reference

Europe PubMed Central

28 July 2017

publication date

18 August 2009

1 reference

Europe PubMed Central

28 July 2017

Molecular Therapy

1 reference

Europe PubMed Central

28 July 2017

18

1 reference

Europe PubMed Central

28 July 2017

2

1 reference

Europe PubMed Central

28 July 2017

307-316

1 reference

Europe PubMed Central

28 July 2017

GAD treatment and insulin secretion in recent-onset type 1 diabetes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2818225

21 June 2018

Diamyd, an alum-formulated recombinant human GAD65 for the prevention of autoimmune diabetes.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2818225

21 June 2018

Gene gun-mediated DNA vaccination enhances antigen-specific immunotherapy at a late preclinical stage of type 1 diabetes in nonobese diabetic mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2818225

21 June 2018

Impact of diabetes susceptibility loci on progression from pre-diabetes to diabetes in at-risk individuals of the diabetes prevention trial-type 1 (DPT-1).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2818225

21 June 2018

Defining the role of the MHC in autoimmunity: a review and pooled analysis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2818225

21 June 2018

Innocuous IFNgamma induced by adjuvant-free antigen restores normoglycemia in NOD mice through inhibition of IL-17 production

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2818225

21 June 2018

Immunization of HLA class I transgenic mice identifies autoantigenic epitopes eliciting dominant responses in type 1 diabetes patients

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2818225

21 June 2018

Moving towards efficient therapies in type 1 diabetes: to combine or not to combine?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2818225

21 June 2018

Antigen-specific precursor frequency impacts T cell proliferation, differentiation, and requirement for costimulation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2818225

21 June 2018

Progress in the development of immune-based therapies for type 1 diabetes mellitus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2818225

21 June 2018

Genetic determinants of type 1 diabetes across populations

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2818225

21 June 2018

Oral tolerance and TGF-beta-producing cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2818225

21 June 2018

Anti-CD3 and nasal proinsulin combination therapy enhances remission from recent-onset autoimmune diabetes by inducing Tregs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2818225

21 June 2018

TCR stimulation with modified anti-CD3 mAb expands CD8+ T cell population and induces CD8+CD25+ Tregs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2818225

21 June 2018

Protection of NOD mice from type 1 diabetes after oral inoculation with vaccinia viruses expressing adjuvanted islet autoantigens

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2818225

21 June 2018

Insulin needs after CD3-antibody therapy in new-onset type 1 diabetes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2818225

21 June 2018

A single course of anti-CD3 monoclonal antibody hOKT3gamma1(Ala-Ala) results in improvement in C-peptide responses and clinical parameters for at least 2 years after onset of type 1 diabetes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2818225

21 June 2018

Prime role for an insulin epitope in the development of type 1 diabetes in NOD mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2818225

21 June 2018

Induction of oral tolerance to prevent diabetes with transgenic plants requires glutamic acid decarboxylase (GAD) and IL-4.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2818225

21 June 2018

CD3 antibody treatment stimulates the functional capability of regulatory T cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2818225

21 June 2018

Vaccination to prevent type 1 diabetes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2818225

21 June 2018

Intradermal or oral delivery of GAD-encoding genetic vaccines suppresses type 1 diabetes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2818225

21 June 2018

Normal incidence of diabetes in NOD mice tolerant to glutamic acid decarboxylase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2818225

21 June 2018

Activation of human T cells by FcR nonbinding anti-CD3 mAb, hOKT3gamma1(Ala-Ala).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2818225

21 June 2018

The role of MHC class II molecules in susceptibility to type I diabetes: identification of peptide epitopes and characterization of the T cell repertoire

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2818225

21 June 2018

T cell response pattern to glutamic acid decarboxylase 65 (GAD65) peptides of newly diagnosed type 1 diabetic patients sharing susceptible HLA haplotypes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2818225

21 June 2018

Modulating autoimmune responses to GAD inhibits disease progression and prolongs islet graft survival in diabetes-prone mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2818225

21 June 2018

Oral insulin treatment suppresses virus-induced antigen-specific destruction of beta cells and prevents autoimmune diabetes in transgenic mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2818225

21 June 2018

Anti-CD3 antibody induces long-term remission of overt autoimmunity in nonobese diabetic mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2818225

21 June 2018

Oral tolerance: immunologic mechanisms and treatment of animal and human organ-specific autoimmune diseases by oral administration of autoantigens

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2818225

21 June 2018

Minimal impact of a de novo-expressed beta-cell autoantigen on spontaneous diabetes development in NOD mice.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2818225

30 October 2018

Direct access to CD4+ T cells specific for defined antigens according to CD154 expression.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2818225

30 October 2018

Clinical evidence for the safety of GAD65 immunomodulation in adult-onset autoimmune diabetes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2818225

30 October 2018

Nonmitogenic CD3 antibody reverses virally induced (rat insulin promoter-lymphocytic choriomeningitis virus) autoimmune diabetes without impeding viral clearance

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2818225

30 October 2018

Induction of GAD65-specific regulatory T-cells inhibits ongoing autoimmune diabetes in nonobese diabetic mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2818225

30 October 2018

How virus induces a rapid or slow onset insulin-dependent diabetes mellitus in a transgenic model

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2818225

30 October 2018

A live-cell assay to detect antigen-specific CD4+ T cells with diverse cytokine profiles

1 reference

https://pubmed.ncbi.nlm.nih.gov/19690518

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

GAD65 autoantibody epitopes in adult patients with latent autoimmune diabetes following GAD65 vaccination

1 reference

https://pubmed.ncbi.nlm.nih.gov/19690518

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The type and frequency of immunoregulatory CD4+ T-cells govern the efficacy of antigen-specific immunotherapy in nonobese diabetic mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/19690518

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Essential roles of TGF-beta in anti-CD3 antibody therapy: reversal of diabetes in nonobese diabetic mice independent of Foxp3+CD4+ regulatory T cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/19690518

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antigen-specific mediated suppression of beta cell autoimmunity by plasmid DNA vaccination

1 reference

https://pubmed.ncbi.nlm.nih.gov/19690518

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Induction of autoimmune diabetes through insulin (but not GAD65) DNA vaccination in nonobese diabetic and in RIP-B7.1 mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/19690518

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

More stringent conditions of plasmid DNA vaccination are required to protect grafted versus endogenous islets in nonobese diabetic mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/19690518

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

T Cell Proliferative Responses to Glutamic Acid Decarboxylase-65 in IDDM are Negatively Associated with HLA DR3/4

1 reference

https://pubmed.ncbi.nlm.nih.gov/19690518

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Treatment with GAD65 or BSA does not protect against diabetes in BB rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/19690518

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expanded T cells from pancreatic lymph nodes of type 1 diabetic subjects recognize an insulin epitope

1 reference

https://pubmed.ncbi.nlm.nih.gov/19690518

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1038/MT.2009.197

1 reference

Europe PubMed Central

28 July 2017

1 reference

Europe PubMed Central

28 July 2017

1 reference

Europe PubMed Central

28 July 2017

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