Therapeutic strategies involving the multidrug resistance phenotype: the MDR1 gene as target, chemoprotectant, and selectable marker in gene therapy. (Q33637632)

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English	Therapeutic strategies involving the multidrug resistance phenotype: the MDR1 gene as target, chemoprotectant, and selectable marker in gene therapy.	scientific article

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scholarly article

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8 December 2019

Therapeutic strategies involving the multidrug resistance phenotype: the MDR1 gene as target, chemoprotectant, and selectable marker in gene therapy (English)

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8 December 2019

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multiple drug resistance

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J M Aran

1

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8 December 2019

I Pastan

2

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8 December 2019

M M Gottesman

3

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8 December 2019

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1 January 1999

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8 December 2019

Advances in Pharmacology

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8 December 2019

46

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8 December 2019

1-42

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Europe PubMed Central

PubMed publication ID

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8 December 2019

Isolation and genetic characterization of human KB cell lines resistant to multiple drugs

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In vitro and in vivo liposome-mediated gene transfer leads to human MDR1 expression in mouse bone marrow progenitor cells

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Generation of a drug resistance profile by quantitation of mdr-1/P-glycoprotein in the cell lines of the National Cancer Institute Anticancer Drug Screen

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Purification and reconstitution of functional human P-glycoprotein

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Partial purification and reconstitution of the human multidrug-resistance pump: characterization of the drug-stimulatable ATP hydrolysis

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Drug-selected coexpression of human glucocerebrosidase and P-glycoprotein using a bicistronic vector

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Complete restoration of glucocerebrosidase deficiency in Gaucher fibroblasts using a bicistronic MDR retrovirus and a new selection strategy

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Reversal of Multidrug Resistance

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Expression of the human multidrug resistance and glucocerebrosidase cDNAs from adeno-associated vectors: efficient promoter activity of AAV sequences and in vivo delivery via liposomes

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Improved retroviral vectors for hematopoietic stem cell protection and in vivo selection

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Novel retroviral vectors for efficient expression of the multidrug resistance (mdr-1) gene in early hematopoietic cells.

1 reference

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7 January 2021

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Altered DNA topoisomerase II in multidrug resistance

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7 January 2021

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Retrovirus-mediated transfer of the multidrug resistance gene into human haemopoietic progenitor cells.

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Gaucher disease: new molecular approaches to diagnosis and treatment

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High dose chemotherapy followed by autologous hematopoietic rescue in Hodgkin's disease: long-term follow-up in 128 patients

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P-glycoprotein, multidrug resistance and tumor progression

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7 January 2021

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Immunohistochemical detection of P-glycoprotein: prognostic correlation in soft tissue sarcoma of childhood

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Induction of multidrug resistance in human cells by transient exposure to different chemotherapeutic drugs.

1 reference

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7 January 2021

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Internal duplication and homology with bacterial transport proteins in the mdr1 (P-glycoprotein) gene from multidrug-resistant human cells.

1 reference

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Identification of glutathione S-transferase as a determinant of 4-hydroperoxycyclophosphamide resistance in human breast cancer cells

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Modulation of activity of the promoter of the human MDR1 gene by Ras and p53.

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An altered pattern of cross-resistance in multidrug-resistant human cells results from spontaneous mutations in the mdr1 (P-glycoprotein) gene

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Overexpression of a transporter gene in a multidrug-resistant human lung cancer cell line

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Transcriptional interference in avian retroviruses—implications for the promoter insertion model of leukaemogenesis

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Active outward transport of daunomycin in resistant Ehrlich ascites tumor cells

1 reference

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Use of safety-modified retroviruses to introduce chemotherapy resistance sequences into normal hematopoietic cells for chemoprotection during the therapy of ovarian cancer: a pilot trial.

1 reference

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7 January 2021

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Evidence for two nonidentical drug-interaction sites in the human P-glycoprotein

1 reference

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7 January 2021

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Dicistronic transcription units for gene expression in mammalian cells

1 reference

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7 January 2021

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1 reference

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Poly(A) signals and transcriptional pause sites combine to prevent interference between RNA polymerase II promoters.

1 reference

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Genetic transfer of non-P-glycoprotein-mediated multidrug resistance (MDR) in somatic cell fusion: dissection of a compound MDR phenotype

1 reference

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The biochemistry of P-glycoprotein-mediated multidrug resistance

1 reference

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Heterologous expression systems for P-glycoprotein:E. coli, yeast, and baculovirus

1 reference

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7 January 2021

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A monoclonal antibody-Pseudomonas toxin conjugate that specifically kills multidrug-resistant cells

1 reference

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7 January 2021

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inferred from DOI database lookup

Expression of a multidrug-resistance gene in human tumors and tissues

1 reference

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7 January 2021

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Amplification of DNA sequences in human multidrug-resistant KB carcinoma cells

1 reference

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1 reference

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Retroviral transfer of the multidrug resistance-1 gene into lineage-committed and primitive hemopoietic cells

1 reference

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7 January 2021

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Frequency analysis of multidrug resistance-1 gene transfer into human primitive hematopoietic progenitor cells using the cobblestone area-forming cell assay and detection of vector-mediated P-glycoprotein expression by rhodamine-123.

1 reference

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1 reference

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1 reference

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1 reference

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7 January 2021

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1 reference

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1 reference

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1 reference

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7 January 2021

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Genetic analysis of the multidrug transporter

1 reference

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7 January 2021

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inferred from DOI database lookup

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1 reference

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1 reference

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1 reference

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1 reference

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1 reference

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7 January 2021

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1 reference

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ABC Transporters: From Microorganisms to Man

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1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

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1 reference

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7 January 2021

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inferred from DOI database lookup

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1 reference

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7 January 2021

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1 reference

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1 reference

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7 January 2021

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1 reference

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7 January 2021

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inferred from DOI database lookup

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1 reference

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7 January 2021

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1 reference

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7 January 2021

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1 reference

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7 January 2021

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1 reference

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7 January 2021

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inferred from DOI database lookup

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1 reference

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7 January 2021

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inferred from DOI database lookup

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1 reference

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7 January 2021

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Expression of a human complementary DNA for the multidrug resistance gene in murine hematopoietic precursor cells with the use of retroviral gene transfer.

1 reference

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7 January 2021

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inferred from DOI database lookup

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1 reference

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7 January 2021

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1 reference

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1 reference

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7 January 2021

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Pseudomonas exotoxin conjugated to monoclonal antibody MRK16 specifically kills multidrug resistant cells in cultured renal carcinomas and in MDR-transgenic mice

1 reference

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7 January 2021

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1 reference

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1 reference

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7 January 2021

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Reversal of drug sensitivity in MDR subline of P388 leukemia by gene-targeted antisense oligonucleotide

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Identification of members of the P-glycoprotein multigene family

1 reference

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7 January 2021

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Quantitative analysis of MDR1 (multidrug resistance) gene expression in human tumors by polymerase chain reaction

1 reference

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Retroviral mediated transfer of the human multidrug resistance gene (MDR-1) into hematopoietic stem cells during autologous transplantation after intensive chemotherapy for metastatic breast cancer

1 reference

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7 January 2021

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alpha-Galactosidase A deficient mice: a model of Fabry disease

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Magnetic-Affinity Cell Sorting of Human Multidrug-Resistant Cells

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A retrovirus carrying an MDR1 cDNA confers multidrug resistance and polarized expression of P-glycoprotein in MDCK cells

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2808%2960468-8

7 January 2021

based on heuristic

inferred from DOI database lookup

Transfer and expression of the human multiple drug resistance gene into live mice

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2808%2960468-8

7 January 2021

based on heuristic

inferred from DOI database lookup

Functional characterization of a glycine 185-to-valine substitution in human P-glycoprotein by using a vaccinia-based transient expression system

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2808%2960468-8

7 January 2021

based on heuristic

inferred from DOI database lookup

Stability and covalent modification of P-glycoprotein in multidrug-resistant KB cells

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2808%2960468-8

7 January 2021

based on heuristic

inferred from DOI database lookup

Efficient transduction of human hematopoietic cells with the human multidrug resistance gene 1 via SV40 pseudovirions

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2808%2960468-8

7 January 2021

based on heuristic

inferred from DOI database lookup

Molecular basis of preferential resistance to colchicine in multidrug-resistant human cells conferred by Gly-185----Val-185 substitution in P-glycoprotein

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2808%2960468-8

7 January 2021

based on heuristic

inferred from DOI database lookup

Targeting of retroviral vectors for gene therapy

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2808%2960468-8

7 January 2021

based on heuristic

inferred from DOI database lookup

Effect of unmodified triple helix-forming oligodeoxyribonucleotide targeted to human multidrug-resistance gene mdr1 in MDR cancer cells

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2808%2960468-8

7 January 2021

based on heuristic

inferred from DOI database lookup

Ribozyme-mediated reversal of the multidrug-resistant phenotype

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2808%2960468-8

7 January 2021

based on heuristic

inferred from DOI database lookup

Normal viability and altered pharmacokinetics in mice lacking mdr1-type (drug-transporting) P-glycoproteins

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2808%2960468-8

7 January 2021

based on heuristic

inferred from DOI database lookup

Reversal of multidrug resistance in human colon cancer cells expressing the human MDR1 gene by liposomes in combination with monoclonal antibody or verapamil

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2808%2960468-8

7 January 2021

based on heuristic

inferred from DOI database lookup

Human multidrug-resistant cell lines: increased mdr1 expression can precede gene amplification

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2808%2960468-8

7 January 2021

based on heuristic

inferred from DOI database lookup

Modulation of multidrug resistance: at the threshold

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2808%2960468-8

7 January 2021

based on heuristic

inferred from DOI database lookup

Cell biological mechanisms of multidrug resistance in tumors

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2808%2960468-8

7 January 2021

based on heuristic

inferred from DOI database lookup

Modulation of multidrug resistance with antisense oligodeoxynucleotide to mdr1 mRNA.

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2808%2960468-8

7 January 2021

based on heuristic

inferred from DOI database lookup

Selection of drug-resistant bone marrow cells in vivo after retroviral transfer of human MDR1

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2808%2960468-8

7 January 2021

based on heuristic

inferred from DOI database lookup

Limited oral bioavailability and active epithelial excretion of paclitaxel (Taxol) caused by P-glycoprotein in the intestine

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2808%2960468-8

7 January 2021

based on heuristic

inferred from DOI database lookup

Efficient expression of drug-selectable genes in retroviral vectors under control of an internal ribosome entry site

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2808%2960468-8

7 January 2021

based on heuristic

inferred from DOI database lookup

Retroviral Coexpression of a Multidrug Resistance Gene (MDR1) and Humanα-Galactosidase A for Gene Therapy of Fabry Disease

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2808%2960468-8

7 January 2021

based on heuristic

inferred from DOI database lookup

Cellular localization of the multidrug-resistance gene product P-glycoprotein in normal human tissues

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2808%2960468-8

7 January 2021

based on heuristic

inferred from DOI database lookup

Overcoming multidrug resistance in human tumor cells using free and liposomally encapsulated antisense oligodeoxynucleotides

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2808%2960468-8

7 January 2021

based on heuristic

inferred from DOI database lookup

Modulation of doxorubicin resistance in multidrug-resistant cells by liposomes

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2808%2960468-8

7 January 2021

based on heuristic

inferred from DOI database lookup

Expression of the multidrug-resistant gene in hepatocarcinogenesis and regenerating rat liver.

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2808%2960468-8

7 January 2021

based on heuristic

inferred from DOI database lookup

Inhibition of multidrug-resistant human tumor growth in athymic mice by anti-P-glycoprotein monoclonal antibodies.

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2808%2960468-8

7 January 2021

based on heuristic

inferred from DOI database lookup

Multidrug resistance

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2808%2960468-8

7 January 2021

based on heuristic

inferred from DOI database lookup

Expression of a full-length cDNA for the human "MDR1" gene confers resistance to colchicine, doxorubicin, and vinblastine

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2808%2960468-8

7 January 2021

based on heuristic

inferred from DOI database lookup

Detection of multidrug resistance (MDR1) gene RNA expression in human tumors by a sensitive ribonuclease protection assay

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2808%2960468-8

7 January 2021

based on heuristic

inferred from DOI database lookup

Effects of lipids on ATPase activity of purified Chinese hamster P-glycoprotein

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2808%2960468-8

7 January 2021

based on heuristic

inferred from DOI database lookup

MDR1 P-glycoprotein is a lipid translocase of broad specificity, while MDR3 P-glycoprotein specifically translocates phosphatidylcholine

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2808%2960468-8

7 January 2021

based on heuristic

inferred from DOI database lookup

Employment of the mdr1 promoter for the chemotherapy-inducible expression of therapeutic genes in cancer gene therapy

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2808%2960468-8

7 January 2021

based on heuristic

inferred from DOI database lookup

Regression of established tumors expressing P-glycoprotein by combinations of adriamycin, cyclosporin derivatives, and MRK-16 antibodies

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2808%2960468-8

7 January 2021

based on heuristic

inferred from DOI database lookup

Comparative study on reversal efficacy of SDZ PSC 833, cyclosporin A and verapamil on multidrug resistance in vitro and in vivo.

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2808%2960468-8

7 January 2021

based on heuristic

inferred from DOI database lookup

Laser scanning and confocal microscopy of daunorubicin, doxorubicin, and rhodamine 123 in multidrug-resistant cells

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2808%2960468-8

7 January 2021

based on heuristic

inferred from DOI database lookup

Protection of bone marrow transplant recipients from lethal doses of methotrexate by the generation of methotrexate-resistant bone marrow

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2808%2960468-8

7 January 2021

based on heuristic

inferred from DOI database lookup

The human multidrug resistance-associated protein MRP is a plasma membrane drug-efflux pump

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2808%2960468-8

7 January 2021

based on heuristic

inferred from DOI database lookup

Co-expression of human adenosine deaminase and multidrug resistance using a bicistronic retroviral vector

1 reference

https://api.crossref.org/works/10.1016%2FS1054-3589%2808%2960468-8

7 January 2021

based on heuristic

inferred from DOI database lookup

Identifiers

10.1016/S1054-3589(08)60468-8

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10332500%20AND%20SRC:MED&resulttype=core&format=json

8 December 2019

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10332500%20AND%20SRC:MED&resulttype=core&format=json

8 December 2019

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