Assay format as a critical success factor for identification of novel inhibitor chemotypes of tissue-nonspecific alkaline phosphatase from high-throughput screening (Q33639954)

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English	Assay format as a critical success factor for identification of novel inhibitor chemotypes of tissue-nonspecific alkaline phosphatase from high-throughput screening	scientific article

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

28 July 2017

3 references

19 September 2019

28 September 2019

22 August 2022

Assay format as a critical success factor for identification of novel inhibitor chemotypes of tissue-nonspecific alkaline phosphatase from high-throughput screening (English)

1 reference

Europe PubMed Central

PubMed publication ID

28 July 2017

biomedical investigative technique

1 reference

19 September 2019

1 reference

28 September 2019

1 reference

based on heuristic

inferred from title

author name string

Thomas D Y Chung

1

1 reference

Europe PubMed Central

PubMed publication ID

28 July 2017

Eduard Sergienko

2

1 reference

Europe PubMed Central

PubMed publication ID

28 July 2017

José Luis Millán

3

1 reference

Europe PubMed Central

PubMed publication ID

28 July 2017

language of work or name

0 references

publication date

27 April 2010

4 references

Europe PubMed Central

PubMed publication ID

28 July 2017

19 September 2019

28 September 2019

22 August 2022

3 references

Europe PubMed Central

PubMed publication ID

28 July 2017

19 September 2019

28 September 2019

15

1 reference

Europe PubMed Central

PubMed publication ID

28 July 2017

5

1 reference

Europe PubMed Central

PubMed publication ID

28 July 2017

3010-3037

1 reference

Europe PubMed Central

PubMed publication ID

28 July 2017

copyright license

Creative Commons Attribution

3 references

19 September 2019

28 September 2019

22 August 2022

copyright status

0 references

High-throughput screening of tissue-nonspecific alkaline phosphatase for identification of effectors with diverse modes of action

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3392958

21 June 2018

Design and synthesis of selective inhibitors of placental alkaline phosphatase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3392958

21 June 2018

Kinetic analysis of substrate utilization by native and TNAP-, NPP1-, or PHOSPHO1-deficient matrix vesicles

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3392958

21 June 2018

Discovery and validation of a series of aryl sulfonamides as selective inhibitors of tissue-nonspecific alkaline phosphatase (TNAP).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3392958

21 June 2018

Identification and characterization of novel tissue-nonspecific alkaline phosphatase inhibitors with diverse modes of action

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3392958

21 June 2018

Inhibitors of Src homology-2 domain containing protein tyrosine phosphatase-2 (Shp2) based on oxindole scaffolds

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3392958

21 June 2018

Intestinal alkaline phosphatase is a gut mucosal defense factor maintained by enteral nutrition

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3392958

21 June 2018

Upregulation of alkaline phosphatase and pyrophosphate hydrolysis: potential mechanism for uremic vascular calcification

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3392958

21 June 2018

Enzyme replacement therapy for murine hypophosphatasia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3392958

21 June 2018

Novel inhibitors of alkaline phosphatase suppress vascular smooth muscle cell calcification

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3392958

21 June 2018

Unique coexpression in osteoblasts of broadly expressed genes accounts for the spatial restriction of ECM mineralization to bone

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3392958

21 June 2018

Functional analysis of the single nucleotide polymorphism (787T>C) in the tissue-nonspecific alkaline phosphatase gene associated with BMD.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3392958

21 June 2018

Concerted regulation of inorganic pyrophosphate and osteopontin by akp2, enpp1, and ank: an integrated model of the pathogenesis of mineralization disorders

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3392958

21 June 2018

Accelerated Fat Absorption in Intestinal Alkaline Phosphatase Knockout Mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3392958

21 June 2018

Mutations in ENPP1 are associated with 'idiopathic' infantile arterial calcification

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3392958

21 June 2018

Rat enterocytes secrete SLPs containing alkaline phosphatase and cubilin in response to corn oil feeding

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3392958

21 June 2018

Intestinal alkaline phosphatase release is not associated with chylomicron formation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3392958

21 June 2018

Tissue-nonspecific alkaline phosphatase and plasma cell membrane glycoprotein-1 are central antagonistic regulators of bone mineralization

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3392958

21 June 2018

Function assignment to conserved residues in mammalian alkaline phosphatases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3392958

21 June 2018

Role of the mouse ank gene in control of tissue calcification and arthritis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3392958

21 June 2018

A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening Assays

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3392958

21 June 2018

Growth factor-like effects of placental alkaline phosphatase in human fetus and mouse embryo fibroblasts

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3392958

21 June 2018

A robotics-based automated assay for inorganic and organic phosphates

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3392958

21 June 2018

Correlations of genotype and phenotype in hypophosphatasia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3392958

21 June 2018

A model of the transition state in the alkaline phosphatase reaction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3392958

21 June 2018

A possible role for rat intestinal surfactant-like particles in transepithelial triacylglycerol transport

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3392958

21 June 2018

Pyrophosphate and diphosphonates in calcium metabolism and their possible role in renal failure

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3392958

21 June 2018

Diphosphonates inhibit formation of calcium phosphate crystals in vitro and pathological calcification in vivo.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3392958

21 June 2018

Seminoma-derived Nagao isozyme is encoded by a germ-cell alkaline phosphatase gene

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3392958

21 June 2018

Comparison of colorimetric, fluorescent, and enzymatic amplification substrate systems in an enzyme immunoassay for detection of DNA-RNA hybrids.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3392958

21 June 2018

Placental alkaline phosphatase as the placental IgG receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3392958

21 June 2018

Different missense mutations at the tissue-nonspecific alkaline phosphatase gene locus in autosomal recessively inherited forms of mild and severe hypophosphatasia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3392958

21 June 2018

Alkaline phosphatase. I. Kinetics and inhibition by levamisole of purified isoenzymes from humans

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3392958

21 June 2018

Design and synthesis of pyrazole derivatives as potent and selective inhibitors of tissue-nonspecific alkaline phosphatase (TNAP).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3392958

30 October 2018

Disruption of the murine intestinal alkaline phosphatase gene Akp3 impairs lipid transcytosis and induces visceral fat accumulation and hepatic steatosis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3392958

30 October 2018

Elevated skeletal osteopontin levels contribute to the hypophosphatasia phenotype in Akp2(-/-) mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3392958

30 October 2018

Involvement of intestinal alkaline phosphatase in serum apolipoprotein B-48 level and its association with ABO and secretor blood group types.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3392958

30 October 2018

Further comparison of primary hit identification by different assay technologies and effects of assay measurement variability

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3392958

30 October 2018

Reduced plasma pyrophosphate levels in hemodialysis patients

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3392958

30 October 2018

Residues determining the binding specificity of uncompetitive inhibitors to tissue-nonspecific alkaline phosphatase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3392958

30 October 2018

Comparison of assay technologies for a tyrosine kinase assay generates different results in high throughput screening

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3392958

30 October 2018

New face of an old enzyme: alkaline phosphatase may contribute to human tissue aging by inducing tissue hardening and calcification

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3392958

30 October 2018

Inactivation of two mouse alkaline phosphatase genes and establishment of a model of infantile hypophosphatasia.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3392958

30 October 2018

Immunolocalization of alkaline phosphatase and surfactant-like particle proteins in rat duodenum during fat absorption.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3392958

30 October 2018

Comparison of SPA, FRET, and FP for kinase assays

1 reference

https://pubmed.ncbi.nlm.nih.gov/20657462

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mapping quantitative trait loci that influence blood levels of alkaline phosphatase in MRL/MpJ and SJL/J mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/20657462

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A novel phosphatase upregulated in Akp3 knockout mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/20657462

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Organ-specific inhibition of human alkaline phosphatase isoenzymes of liver, bone, intestine and placenta; L-phenylalanine, L-tryptophan and L homoarginine

1 reference

https://pubmed.ncbi.nlm.nih.gov/20657462

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased lymph alkaline phosphatase after fat feeding: Effects of medium chain triglycerides and inhibition of protein synthesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/20657462

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Can biological calcification occur in the presence of pyrophosphate?

1 reference

https://pubmed.ncbi.nlm.nih.gov/20657462

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Human skeletal alkaline phosphatase. Kinetic studies including pH dependence and inhibition by theophylline

1 reference

https://pubmed.ncbi.nlm.nih.gov/20657462

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Kinetic parameters for the cleaved substrate, and enzyme and substrate stability, vary with the phosphoacceptor in alkaline phosphatase catalysis

1 reference

https://pubmed.ncbi.nlm.nih.gov/20657462

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of the phosphatidylinositol-specific phospholipase C-released form of rat osseous plate alkaline phosphatase and its possible significance on endochondral ossification

1 reference

https://pubmed.ncbi.nlm.nih.gov/20657462

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.3390/MOLECULES15053010

1 reference

Europe PubMed Central

PubMed publication ID

28 July 2017

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

28 July 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

28 July 2017

ResearchGate publication ID

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