MMP-9, uPAR and cathepsin B silencing downregulate integrins in human glioma xenograft cells in vitro and in vivo in nude mice (Q33640030)

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English	MMP-9, uPAR and cathepsin B silencing downregulate integrins in human glioma xenograft cells in vitro and in vivo in nude mice	scientific article

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scholarly article

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Europe PubMed Central

PubMed publication ID

28 July 2017

MMP-9, uPAR and cathepsin B silencing downregulate integrins in human glioma xenograft cells in vitro and in vivo in nude mice (English)

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Europe PubMed Central

PubMed publication ID

28 July 2017

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Christopher S Gondi

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Christopher S Gondi

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Jasti S Rao

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Europe PubMed Central

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28 July 2017

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Krishna Kumar Veeravalli

1

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28 July 2017

Chandramu Chetty

2

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28 July 2017

Shivani Ponnala

3

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28 July 2017

Sajani S Lakka

5

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28 July 2017

Daniel Fassett

6

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28 July 2017

Jeffrey D Klopfenstein

7

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28 July 2017

Dzung H Dinh

8

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28 July 2017

Meena Gujrati

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28 July 2017

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15 July 2010

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Europe PubMed Central

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28 July 2017

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Europe PubMed Central

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28 July 2017

5

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Europe PubMed Central

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28 July 2017

7

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28 July 2017

e11583

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Europe PubMed Central

PubMed publication ID

28 July 2017

copyright license

Creative Commons Attribution 4.0 International

15 July 2010

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April 2022 Public Data File from Crossref

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0 references

Integrin alpha9beta1: Unique signaling pathways reveal diverse biological roles

1 reference

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14 July 2018

Integrins in cancer: biological implications and therapeutic opportunities

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14 July 2018

Regulation of cell signalling by uPAR.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2904700

14 July 2018

Integrin alpha9beta1 mediates enhanced cell migration through nitric oxide synthase activity regulated by Src tyrosine kinase

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14 July 2018

Therapeutic potential of siRNA-mediated targeting of urokinase plasminogen activator, its receptor, and matrix metalloproteinases

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Regulatory effect of nerve growth factor in alpha9beta1 integrin-dependent progression of glioblastoma.

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14 July 2018

Simultaneous downregulation of uPAR and MMP-9 induces overexpression of the FADD-associated protein RIP and activates caspase 9-mediated apoptosis in gliomas.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2904700

14 July 2018

uPAR promotes formation of the p130Cas-Crk complex to activate Rac through DOCK180.

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14 July 2018

The alpha9beta1 integrin enhances cell migration by polyamine-mediated modulation of an inward-rectifier potassium channel

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14 July 2018

RNA interference-mediated simultaneous down-regulation of urokinase-type plasminogen activator receptor and cathepsin B induces caspase-8-mediated apoptosis in SNB19 human glioma cells

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14 July 2018

Integrin-regulated FAK-Src signaling in normal and cancer cells

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14 July 2018

A region in urokinase plasminogen receptor domain III controlling a functional association with alpha5beta1 integrin and tumor growth

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14 July 2018

Proteases and glioma angiogenesis.

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14 July 2018

Patient tumor EGFR and PDGFRA gene amplifications retained in an invasive intracranial xenograft model of glioblastoma multiforme

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14 July 2018

Specific interference of urokinase-type plasminogen activator receptor and matrix metalloproteinase-9 gene expression induced by double-stranded RNA results in decreased invasion, tumor growth, and angiogenesis in gliomas.

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2904700

14 July 2018

Regulation of urokinase receptor proteolytic function by the tetraspanin CD82.

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14 July 2018

Integrin signalling during tumour progression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2904700

14 July 2018

Inhibition of cathepsin B and MMP-9 gene expression in glioblastoma cell line via RNA interference reduces tumor cell invasion, tumor growth and angiogenesis.

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14 July 2018

siRNAs: applications in functional genomics and potential as therapeutics

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14 July 2018

Expression of antisense uPAR and antisense uPA from a bicistronic adenoviral construct inhibits glioma cell invasion, tumor growth, and angiogenesis.

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14 July 2018

Activated integrin alphavbeta3 cooperates with metalloproteinase MMP-9 in regulating migration of metastatic breast cancer cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2904700

14 July 2018

Molecular mechanisms of glioma invasiveness: the role of proteases

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2904700

14 July 2018

Integrins: bidirectional, allosteric signaling machines

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2904700

14 July 2018

The cytoplasmic domain of the integrin alpha9 subunit requires the adaptor protein paxillin to inhibit cell spreading but promotes cell migration in a paxillin-independent manner

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2904700

14 July 2018

Localization of gelatinase-A and gelatinase-B mRNA and protein in human gliomas

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2904700

14 July 2018

Fibronectin and its integrin receptors in cancer

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2904700

14 July 2018

Regulation of tumor cell invasion by extracellular matrix

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14 July 2018

In vitro inhibition of human glioblastoma cell line invasiveness by antisense uPA receptor

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14 July 2018

Glioma invasion in the central nervous system

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14 July 2018

Focal adhesion kinase and associated proteins

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2904700

14 July 2018

Identification of two new exons and multiple transcription start points in the 5'-untranslated region of the human cathepsin-B-encoding gene

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2904700

14 July 2018

Urokinase receptor is a multifunctional protein: influence of receptor occupancy on macrophage gene expression

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2904700

14 July 2018

Integrins and other cell adhesion molecules

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14 July 2018

VLA proteins in the integrin family: structures, functions, and their role on leukocytes

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14 July 2018

Protein tyrosine phosphorylation and the adhesive functions of platelets

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14 July 2018

Integrins: versatility, modulation, and signaling in cell adhesion

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14 July 2018

Focal adhesion kinase (p125FAK): a point of convergence in the action of neuropeptides, integrins, and oncogenes

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14 July 2018

Expression of matrix metalloproteinases and their inhibitors in human brain tumors.

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21 January 2018

ECM-mediated glioma cell invasion

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21 January 2018

Modification of kidney barrier function by the urokinase receptor.

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21 January 2018

The RNAi revolution.

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Comparison of cell adhesion molecule expression between glioblastoma multiforme and autologous normal brain tissue.

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Processing of integrin alpha(v) subunit by membrane type 1 matrix metalloproteinase stimulates migration of breast carcinoma cells on vitronectin and enhances tyrosine phosphorylation of focal adhesion kinase

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21 January 2018

Binding of Paxillin to the alpha 9 Integrin Cytoplasmic Domain Inhibits Cell Spreading

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Integrin alpha9beta1 directly binds to vascular endothelial growth factor (VEGF)-A and contributes to VEGF-A-induced angiogenesis

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21 January 2018

Expression of extracellular matrix components in a highly infiltrative in vivo glioma model

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30 October 2018

Comparative analysis of matrix metalloproteinases by immunocytochemistry, immunohistochemistry and zymography in human primary brain tumours.

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Elevated levels of M(r) 92,000 type IV collagenase in human brain tumors

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Expression and localization of urokinase-type plasminogen activator receptor in human gliomas.

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Cathepsin B expression and localization in glioma progression and invasion.

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Inhibition of FAK signaling activated by urokinase receptor induces dormancy in human carcinoma cells in vivo

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High levels of urokinase-type plasminogen activator and its inhibitor PAI-1 in cytosolic extracts of breast carcinomas are associated with poor prognosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/20657647

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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10.1371/JOURNAL.PONE.0011583

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Europe PubMed Central

PubMed publication ID

28 July 2017

2010PLoSO...511583V

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PMC publication ID

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Europe PubMed Central

PubMed publication ID

28 July 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

28 July 2017

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