Assessing cytochrome P450 and UDP-glucuronosyltransferase contributions to warfarin metabolism in humans. (Q33644101)

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27 January 2020

title

Assessing cytochrome P450 and UDP-glucuronosyltransferase contributions to warfarin metabolism in humans (English)

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27 January 2020

1 reference

1

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27 January 2020

Drew R Jones

2

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27 January 2020

author name string

Shane Z Sullivan

3

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27 January 2020

Anna Mazur

4

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27 January 2020

Suzanne N Owen

5

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27 January 2020

Neil C Mitchell

6

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Anna Radominska-Pandya

7

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27 January 2020

Jeffery H Moran

8

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publication date

1 July 2009

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Chemical Research in Toxicology

27 January 2020

published in

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volume

22

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issue

7

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27 January 2020

page(s)

1239-1245

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Identification of hydroxywarfarin binding site in human UDP glucuronosyltransferase 1a10: phenylalanine90 is crucial for the glucuronidation of 6- and 7-hydroxywarfarin but not 8-hydroxywarfarin

27 January 2020

cites work

1 reference

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The critical path of warfarin dosing: finding an optimal dosing strategy using pharmacogenetics

21 June 2018

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A genome-wide scan for common genetic variants with a large influence on warfarin maintenance dose

21 June 2018

1 reference

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Glucuronidation of monohydroxylated warfarin metabolites by human liver microsomes and human recombinant UDP-glucuronosyltransferases

21 June 2018

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Association of warfarin dose with genes involved in its action and metabolism

21 June 2018

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Mass spectrometry-based metabolomics

21 June 2018

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Roles of glucuronidation and UDP-glucuronosyltransferases in xenobiotic bioactivation reactions

21 June 2018

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Human P450 metabolism of warfarin

21 June 2018

1 reference

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Metabolism of vitamin K and vitamin K 2,3-epoxide via interaction with a common disulfide

21 June 2018

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Phase II metabolism of warfarin in primary culture of adult rat hepatocytes

21 June 2018

1 reference

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Hydroxylation of warfarin by human cDNA-expressed cytochrome P-450: a role for P-4502C9 in the etiology of (S)-warfarin-drug interactions

21 June 2018

1 reference

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Synthesis and structure-activity relationships of novel warfarin derivatives.

21 June 2018

1 reference

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Allelic variants of human cytochrome P450 2C9: baculovirus-mediated expression, purification, structural characterization, substrate stereoselectivity, and prochiral selectivity of the wild-type and I359L mutant forms.

30 October 2018

1 reference

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Pharmacogenomics of 4-hydroxycoumarin anticoagulants

30 October 2018

1 reference

12 December 2020

Correlation of human cytochrome P4502C substrate specificities with primary structure: warfarin as a probe

1 reference

12 December 2020

Human cytochromes P4501A1 and P4501A2: R-warfarin metabolism as a probe

1 reference

12 December 2020

Formation of (R)-8-hydroxywarfarin in human liver microsomes. A new metabolic marker for the (S)-mephenytoin hydroxylase, P4502C19

1 reference

12 December 2020

Identifiers

DOI

10.1021/TX900031Z

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27 January 2020

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27 January 2020

PubMed publication ID

19408964

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