Cholesterol crystals activate the NLRP3 inflammasome in human macrophages: a novel link between cholesterol metabolism and inflammation (Q33644572)

28 July 2017

Cholesterol crystals activate the NLRP3 inflammasome in human macrophages: a novel link between cholesterol metabolism and inflammation (English)

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28 July 2017

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Kristiina Rajamäki

1

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Petri T Kovanen

6

object named as

Petri T Kovanen

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28 July 2017

Jani Lappalainen

2

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28 July 2017

Katariina Oörni

3

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28 July 2017

Elina Välimäki

4

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28 July 2017

Sampsa Matikainen

5

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28 July 2017

Kari K Eklund

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28 July 2017

language of work or name

English

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publication date

23 July 2010

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28 July 2017

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28 July 2017

5

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28 July 2017

e11765

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28 July 2017

7

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Creative Commons Attribution 4.0 International

28 July 2017

start time

23 July 2010

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April 2022 Public Data File from Crossref

copyright status

copyrighted

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cites work

NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals

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NLRP3 inflammasome activation: The convergence of multiple signalling pathways on ROS production?

14 July 2018

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The inflammasomes: mechanisms of activation and function

14 July 2018

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Cutting edge: NF-kappaB activating pattern recognition and cytokine receptors license NLRP3 inflammasome activation by regulating NLRP3 expression

14 July 2018

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The density of GM1-enriched lipid rafts correlates inversely with the efficiency of transfection mediated by cationic liposomes

14 July 2018

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The inflammasomes: guardians of the body

14 July 2018

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Immune and inflammatory mechanisms of atherosclerosis (*)

14 July 2018

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Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization

14 July 2018

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Innate immune activation through Nalp3 inflammasome sensing of asbestos and silica

14 July 2018

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The roles of pathogen-associated molecular patterns in atherosclerosis.

14 July 2018

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The inflammasome recognizes cytosolic microbial and host DNA and triggers an innate immune response

14 July 2018

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Activation of the NALP3 inflammasome is triggered by low intracellular potassium concentration

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2909263

Expression profiling of lipopolysaccharide target genes in RAW264.7 cells by oligonucleotide microarray analyses

14 July 2018

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Cytokines in atherosclerosis: pathogenic and regulatory pathways

14 July 2018

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Cryopyrin activates the inflammasome in response to toxins and ATP

14 July 2018

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Gout-associated uric acid crystals activate the NALP3 inflammasome

14 July 2018

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Cathepsin L expression and regulation in human abdominal aortic aneurysm, atherosclerosis, and vascular cells

14 July 2018

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Lack of Toll-like receptor 4 or myeloid differentiation factor 88 reduces atherosclerosis and alters plaque phenotype in mice deficient in apolipoprotein E

14 July 2018

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Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method

14 July 2018

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Virus infection induces proteolytic processing of IL-18 in human macrophages via caspase-1 and caspase-3 activation

14 July 2018

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The extra domain A of fibronectin activates Toll-like receptor 4.

14 July 2018

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Cutting edge: heat shock protein 60 is a putative endogenous ligand of the toll-like receptor-4 complex

14 July 2018

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Cutting edge: heat shock protein (HSP) 60 activates the innate immune response: CD14 is an essential receptor for HSP60 activation of mononuclear cells

14 July 2018

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Crystallization of free cholesterol in model macrophage foam cells

14 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2909263

Ala-Pro-cresyl violet, a synthetic fluorogenic substrate for the analysis of kinetic parameters of dipeptidyl peptidase IV (CD26) in individual living rat hepatocytes

14 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2909263

Transitional features in human atherosclerosis. Intimal thickening, cholesterol clefts, and cell loss in human aortic fatty streaks

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2909263

Formation of cholesterol monohydrate crystals in macrophage-derived foam cells.

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2909263

Galactose-binding site in Escherichia coli heat-labile enterotoxin (LT) and cholera toxin (CT)

14 July 2018

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Sequestration of acetylated LDL and cholesterol crystals by human monocyte-derived macrophages

14 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2909263

Induction of nitric oxide synthase gene by interleukin in vascular smooth muscle cells

14 July 2018

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Evidence for apoptosis in advanced human atheroma. Colocalization with interleukin-1 beta-converting enzyme

14 July 2018

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Human cathepsin B. Application of the substrate N-benzyloxycarbonyl-L-arginyl-L-arginine 2-naphthylamide to a study of the inhibition by leupeptin

14 July 2018

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Ultrastructure of the human aortic fibrolipid lesion. Formation of the atherosclerotic lipid-rich core

14 July 2018

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Interleukin-1: amino acid sequences, multiple biological activities and comparison with tumor necrosis factor (cachectin).

14 July 2018

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The cell surface receptors for interleukin-1 alpha and interleukin-1 beta are identical

14 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2909263

Review: Transcriptional and post-transcriptional regulation of interleukin 1 gene expression

14 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2909263

Physical chemistry of the lipids of human atherosclerotic lesions. Demonstration of a lesion intermediate between fatty streaks and advanced plaques

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2909263

Effect of cholesterol crystals on plaques and intima in arteries of patients with acute coronary and cerebrovascular syndromes.

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2909263

Serum, but not monocyte macrophage foam cells derived from low HDL-C subjects, displays reduced cholesterol efflux capacity

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2909263

Toll-like receptor 4-dependent and -independent cytokine secretion induced by minimally oxidized low-density lipoprotein in macrophages.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2909263

CA-074, but not its methyl ester CA-074Me, is a selective inhibitor of cathepsin B within living cells

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2909263

In vivo imaging of proteolytic activity in atherosclerosis

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2909263

Lack of Interleukin-1β Decreases the Severity of Atherosclerosis in ApoE-Deficient Mice

30 October 2018

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12 December 2020

Cholesterol Solubility in Organic Solvents

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12 December 2020

Human pro-IL-1 beta gene expression in monocytic cells is regulated by two distinct pathways

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12 December 2020

The kinetics of interleukin 1 secretion from activated monocytes. Differences between interleukin 1 alpha and interleukin 1 beta

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12 December 2020

Cholesterol crystal uptake and metabolism by P388D1 macrophages

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12 December 2020

Differential activity of interleukin 1 alpha and interleukin 1 beta in the stimulation of the immune response in vivo

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12 December 2020

Novel epoxysuccinyl peptides. Selective inhibitors of cathepsin B, in vitro

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12 December 2020

Novel epoxysuccinyl peptides. A selective inhibitor of cathepsin B, in vivo

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12 December 2020

CA074 methyl ester: a proinhibitor for intracellular cathepsin B

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12 December 2020

Mechanical properties of model atherosclerotic lesion lipid pools

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12 December 2020

Interleukin-1 beta induces expression of adhesion molecules in human vascular smooth muscle cells and enhances adhesion of leukocytes to smooth muscle cells

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12 December 2020

Interleukin-1 beta in coronary arteries of patients with ischemic heart disease

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12 December 2020

Interleukin-1 beta, interleukin-18, and the interleukin-1 beta converting enzyme

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12 December 2020

Interleukin-1 beta induces endothelin-1 gene by multiple mechanisms

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12 December 2020

Atherosclerotic lesion development and Toll like receptor 2 and 4 responsiveness

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12 December 2020

10.1371/JOURNAL.PONE.0011765

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28 July 2017

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28 July 2017

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