Nuclear factor-kappaB (NF-kappaB) is a novel positive transcriptional regulator of the oncogenic Wip1 phosphatase (Q33648301)

28 July 2017

title

Nuclear factor-kappaB (NF-kappaB) is a novel positive transcriptional regulator of the oncogenic Wip1 phosphatase (English)

1 reference

28 July 2017

0 references

Albert J Fornace

4

0 references

author name string

Julie M Lowe

series ordinal

1

1 reference

28 July 2017

Hyukjin Cha

series ordinal

2

1 reference

28 July 2017

Qian Yang

series ordinal

3

1 reference

28 July 2017

language of work or name

English

0 references

publication date

10 December 2009

1 reference

Journal of Biological Chemistry

28 July 2017

number of pages

9

1 reference

based on heuristic

inferred from page(s)

published in

1 reference

28 July 2017

volume

285

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28 July 2017

issue

8

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28 July 2017

page(s)

5249-5257

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Loss of Wip1 sensitizes cells to stress- and DNA damage-induced apoptosis

28 July 2017

cites work

1 reference

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WIP1 phosphatase is a negative regulator of NF-kappaB signalling

21 June 2018

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Downregulation of Wip-1 phosphatase expression in MCF-7 breast cancer cells enhances doxorubicin-induced apoptosis through p53-mediated transcriptional activation of Bax.

21 June 2018

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Is NF-kappaB a good target for cancer therapy? Hopes and pitfalls

21 June 2018

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Induction of autophagic cell death and radiosensitization by the pharmacological inhibition of nuclear factor-kappa B activation in human glioma cell lines

21 June 2018

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Induction of PPM1D following DNA-damaging treatments through a conserved p53 response element coincides with a shift in the use of transcription initiation sites

21 June 2018

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NF-kappaB and cancer-identifying targets and mechanisms

21 June 2018

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An agonist of toll-like receptor 5 has radioprotective activity in mouse and primate models

21 June 2018

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PPM1D silencing by RNA interference inhibits proliferation and induces apoptosis in breast cancer cell lines with wild-type p53.

21 June 2018

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Curcumin inhibits NFkappaB mediated radioprotection and modulate apoptosis related genes in human neuroblastoma cells

21 June 2018

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Shared principles in NF-kappaB signaling

21 June 2018

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The type 2C phosphatase Wip1: an oncogenic regulator of tumor suppressor and DNA damage response pathways.

21 June 2018

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NF-kappa B-mediated adaptive resistance to ionizing radiation

21 June 2018

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A functional role for p38 MAPK in modulating mitotic transit in the absence of stress

21 June 2018

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Nuclear factor-kappaB and manganese superoxide dismutase mediate adaptive radioresistance in low-dose irradiated mouse skin epithelial cells.

21 June 2018

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The transcription factor nuclear factor-kappa B and cancer

21 June 2018

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Nuclear factor-kappaB in development, prevention, and therapy of cancer

21 June 2018

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Integrating cell-signalling pathways with NF-kappaB and IKK function

21 June 2018

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NF-kappaB and the immune response

21 June 2018

1 reference

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E2F1 modulates p38 MAPK phosphorylation via transcriptional regulation of ASK1 and Wip1.

21 June 2018

1 reference

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Overexpression of the wip1 gene abrogates the p38 MAPK/p53/Wip1 pathway and silences p16 expression in human breast cancers

21 June 2018

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A new IkappaB kinase beta inhibitor prevents human breast cancer progression through negative regulation of cell cycle transition

21 June 2018

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Chemical inhibition of Wip1 phosphatase contributes to suppression of tumorigenesis

21 June 2018

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The biology of p38 kinase: a central role in inflammation

21 June 2018

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NF-kappaB: linking inflammation and immunity to cancer development and progression

21 June 2018

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Increased radiation-induced apoptosis of Saos2 cells via inhibition of NFkappaB: a role for c-Jun N-terminal kinase.

21 June 2018

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Substrate specificity of the human protein phosphatase 2Cdelta, Wip1

21 June 2018

1 reference

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NF-kappaB inhibition radiosensitizes Ki-Ras-transformed cells to ionizing radiation

21 June 2018

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Identification of direct genomic targets downstream of the nuclear factor-kappaB transcription factor mediating tumor necrosis factor signaling.

21 June 2018

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Phosphorylation of NF-kappaB and IkappaB proteins: implications in cancer and inflammation

21 June 2018

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A novel NF-kappaB inhibitor, IMD-0354, suppresses neoplastic proliferation of human mast cells with constitutively activated c-kit receptors

21 June 2018

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21 June 2018

Signaling to NF-kappaB

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Inhibition of constitutively activated nuclear factor-kappaB radiosensitizes human melanoma cells.

21 June 2018

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The p38 MAP kinase pathway as a therapeutic target in inflammatory disease

21 June 2018

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Stabilization of p53 is a novel mechanism for proapoptotic function of NF-kappaB.

21 June 2018

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Amplification of PPM1D in human tumors abrogates p53 tumor-suppressor activity

21 June 2018

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Innate immune recognition

21 June 2018

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Activation of nuclear factor kappaB in radioresistance of TP53-inactive human keratinocytes.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2820753

Mice deficient for the wild-type p53-induced phosphatase gene (Wip1) exhibit defects in reproductive organs, immune function, and cell cycle control

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2820753

p53-inducible wip1 phosphatase mediates a negative feedback regulation of p38 MAPK-p53 signaling in response to UV radiation

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2820753

Activators and target genes of Rel/NF-kappaB transcription factors

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2820753

JNK and p53 stress signaling cascades are altered in MCF-7 cells resistant to tumor necrosis factor-mediated apoptosis

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2820753

Wip1, a novel human protein phosphatase that is induced in response to ionizing radiation in a p53-dependent manner

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2820753

NF-kappa B RelA-deficient lymphocytes: normal development of T cells and B cells, impaired production of IgA and IgG1 and reduced proliferative responses

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2820753

The p53-mdm-2 autoregulatory feedback loop

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2820753

Inactivation of the Wip1 phosphatase inhibits mammary tumorigenesis through p38 MAPK-mediated activation of the p16(Ink4a)-p19(Arf) pathway

21 June 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.034579

The role of the MKK6/p38 MAPK pathway in Wip1-dependent regulation of ErbB2-driven mammary gland tumorigenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.034579

NF-kappaB blockade and oncogenic Ras trigger invasive human epidermal neoplasia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.034579

Wip1 phosphatase regulates p53-dependent apoptosis of stem cells and tumorigenesis in the mouse intestine.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.034579

Targeted drug delivery to mesothelioma cells using functionally selected internalizing human single-chain antibodies

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.034579

Wip1 Phosphatase Modulates ATM-Dependent Signaling Pathways

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20007970

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1074/JBC.M109.034579

1 reference

28 July 2017

1 reference

28 July 2017

1 reference