An agonist of toll-like receptor 5 has radioprotective activity in mouse and primate models (Q34769152)

4 August 2017

title

An agonist of toll-like receptor 5 has radioprotective activity in mouse and primate models (English)

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4 August 2017

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Lyudmila G Burdelya

1

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4 August 2017

Vadim I Krivokrysenko

2

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4 August 2017

Thomas C Tallant

3

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4 August 2017

Evguenia Strom

4

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4 August 2017

Anatoly S Gleiberman

5

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4 August 2017

Damodar Gupta

6

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4 August 2017

Oleg V Kurnasov

7

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4 August 2017

Farrel L Fort

8

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4 August 2017

Andrei L Osterman

9

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4 August 2017

Joseph A Didonato

10

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4 August 2017

Elena Feinstein

11

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4 August 2017

Andrei V Gudkov

12

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4 August 2017

language of work or name

English

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publication date

1 April 2008

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4 August 2017

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4 August 2017

volume

320

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4 August 2017

issue

5873

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4 August 2017

page(s)

226-230

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Immunogenic chemotherapy: discovery of a critical protein through proteomic analyses of tumor cells.

4 August 2017

cites work

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5-androstenediol improves survival in clinically unsupported rhesus monkeys with radiation-induced myelosuppression

7 July 2018

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7 July 2018

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TLR5-mediated phosphoinositide 3-kinase activation negatively regulates flagellin-induced proinflammatory gene expression

7 July 2018

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Small molecules that reactivate p53 in renal cell carcinoma reveal a NF-kappaB-dependent mechanism of p53 suppression in tumors

7 July 2018

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Effects of flagellin on innate and adaptive immunity

7 July 2018

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Altered epithelial cell lineage allocation and global expansion of the crypt epithelial stem cell population are associated with ileitis in SAMP1/YitFc mice

7 July 2018

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Cytokine overexpression and constitutive NFkappaB in cancer

7 July 2018

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Flagellin acting via TLR5 is the major activator of key signaling pathways leading to NF-kappa B and proinflammatory gene program activation in intestinal epithelial cells

7 July 2018

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Signal transduction pathways regulating cyclooxygenase-2 expression: potential molecular targets for chemoprevention

7 July 2018

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Recognition of commensal microflora by toll-like receptors is required for intestinal homeostasis

7 July 2018

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Medical management of the acute radiation syndrome: recommendations of the Strategic National Stockpile Radiation Working Group

7 July 2018

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Identification of conserved domains in Salmonella muenchen flagellin that are essential for its ability to activate TLR5 and to induce an inflammatory response in vitro

7 July 2018

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Radiation and ceramide-induced apoptosis

7 July 2018

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Protection against ionizing radiation by antioxidant nutrients and phytochemicals

7 July 2018

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The role of p53 in determining sensitivity to radiotherapy

7 July 2018

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Colony-stimulating factors for the management of neutropenia in cancer patients

7 July 2018

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Manganese superoxide dismutase (SOD2) inhibits radiation-induced apoptosis by stabilization of the mitochondrial membrane

7 July 2018

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Androstenediol stimulates myelopoiesis and enhances resistance to infection in gamma-irradiated mice

7 July 2018

1 reference

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A chemical inhibitor of p53 that protects mice from the side effects of cancer therapy

7 July 2018

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Pharmacologic approaches to protection against radiation-induced lethality and other damage

7 July 2018

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Abrogation of radiation injury to human hematopoietic stem cells with tumor necrosis factor-alpha

7 July 2018

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Role of cytokines (interleukin 1, tumor necrosis factor, and transforming growth factor beta) in natural and lipopolysaccharide-enhanced radioresistance

7 July 2018

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The significance of spontaneous and induced apoptosis in the gastrointestinal tract of mice

7 July 2018

1 reference

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Detection of pathogenic intestinal bacteria by Toll-like receptor 5 on intestinal CD11c+ lamina propria cells.

7 July 2018

1 reference

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Activation of nuclear factor kappaB In vivo selectively protects the murine small intestine against ionizing radiation-induced damage.

26 October 2018

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Human intestinal microvascular endothelial cells express Toll-like receptor 5: a binding partner for bacterial flagellin

26 October 2018

1 reference

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Dual effect of p53 on radiation sensitivity in vivo: p53 promotes hematopoietic injury, but protects from gastro-intestinal syndrome in mice.

26 October 2018

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Endothelial apoptosis as the primary lesion initiating intestinal radiation damage in mice.

26 October 2018

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Flagellin, a novel mediator of Salmonella-induced epithelial activation and systemic inflammation: I kappa B alpha degradation, induction of nitric oxide synthase, induction of proinflammatory mediators, and cardiovascular dysfunction.

26 October 2018

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Cloning and characterization of the murine toll-like receptor 5 (Tlr5) gene: sequence and mRNA expression studies in Salmonella-susceptible MOLF/Ei mice

26 October 2018

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Toll-like receptors: linking innate and adaptive immunity

26 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/18403709

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

p53-deficient mice are extremely susceptible to radiation-induced tumorigenesis

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/18403709

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Effect of in vivo administration of IL-3 and IL-6, alone and in combination with G-CSF, GM-CSF or IL-1, on haematopoiesis, graft-versus-host disease and survival after murine haematopoietic stem cell transplantation

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/18403709

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1126/SCIENCE.1154986

1 reference

4 August 2017

1 reference

4 August 2017

1 reference