The role of cytochrome P450 2B6 and 2B4 substrate access channel residues predicted based on crystal structures of the amlodipine complexes (Q33648450)

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5 March 2020

title

The role of cytochrome P450 2B6 and 2B4 substrate access channel residues predicted based on crystal structures of the amlodipine complexes (English)

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5 March 2020

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2

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5 March 2020

Chul-Ho Yun

4

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5 March 2020

author name string

Hyun-Hee Jang

1

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5 March 2020

Ga-Young Lee

3

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5 March 2020

James R Halpert

5

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5 March 2020

language of work or name

English

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publication date

18 January 2014

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Archives of Biochemistry and Biophysics

5 March 2020

published in

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5 March 2020

volume

545

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5 March 2020

page(s)

100-107

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Structural diversity of eukaryotic membrane cytochrome p450s

5 March 2020

cites work

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Potent Mechanism-Based Inactivation of Cytochrome P450 2B4 by 9-Ethynylphenanthrene: Implications for Allosteric Modulation of Cytochrome P450 Catalysis

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Conformational Adaptation of Human Cytochrome P450 2B6 and Rabbit Cytochrome P450 2B4 Revealed upon Binding Multiple Amlodipine Molecules

21 June 2018

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Nicotine and 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone Binding and Access Channel in Human Cytochrome P450 2A6 and 2A13 Enzymes

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Three-dimensional structure of steroid 21-hydroxylase (cytochrome P450 21A2) with two substrates reveals locations of disease-associated variants

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Peripheral ligand-binding site in cytochrome P450 3A4 located with fluorescence resonance energy transfer (FRET)

21 June 2018

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Membrane position of ibuprofen agrees with suggested access path entrance to cytochrome P450 2C9 active site

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Structural Analysis of Mammalian Cytochrome P450 2B4 Covalently Bound to the Mechanism-Based Inactivator tert -Butylphenylacetylene: Insight into Partial Enzymatic Activity

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Multiple substrate-binding sites are retained in cytochrome P450 3A4 mutants with decreased cooperativity.

21 June 2018

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Structures of Cytochrome P450 2B4 Complexed with the Antiplatelet Drugs Ticlopidine and Clopidogrel,

21 June 2018

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Structural basis of human CYP51 inhibition by antifungal azoles

21 June 2018

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Crystal Structure of CYP24A1, a Mitochondrial Cytochrome P450 Involved in Vitamin D Metabolism

21 June 2018

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Theoretical characterization of substrate access/exit channels in the human cytochrome P450 3A4 enzyme: involvement of phenylalanine residues in the gating mechanism

21 June 2018

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Allosteric transitions in cytochrome P450eryF explored with pressure-perturbation spectroscopy, lifetime FRET, and a novel fluorescent substrate, Fluorol-7GA.

21 June 2018

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Structures of human cytochrome P-450 2E1. Insights into the binding of inhibitors and both small molecular weight and fatty acid substrates

21 June 2018

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Determinants of Cytochrome P450 2C8 Substrate Binding: STRUCTURES OF COMPLEXES WITH MONTELUKAST, TROGLITAZONE, FELODIPINE, AND 9-CIS-RETINOIC ACID

21 June 2018

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Structural basis for ligand promiscuity in cytochrome P450 3A4.

21 June 2018

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The ins and outs of cytochrome P450s.

21 June 2018

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Structure of microsomal cytochrome P450 2B4 complexed with the antifungal drug bifonazole: insight into P450 conformational plasticity and membrane interaction.

21 June 2018

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Structural biology of heme monooxygenases

21 June 2018

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Structural diversity of human xenobiotic-metabolizing cytochrome P450 monooxygenases

21 June 2018

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Do mammalian cytochrome P450s show multiple ligand access pathways and ligand channelling?

21 June 2018

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A survey of active site access channels in cytochromes P450.

21 June 2018

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Structure of mammalian cytochrome P450 2B4 complexed with 4-(4-chlorophenyl)imidazole at 1.9-A resolution: insight into the range of P450 conformations and the coordination of redox partner binding

21 June 2018

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Mutagenesis and molecular dynamics suggest structural and functional roles for residues in the N-terminal portion of the cytochrome P450 2B1 I helix

21 June 2018

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THE CARBON MONOXIDE-BINDING PIGMENT OF LIVER MICROSOMES. II. SOLUBILIZATION, PURIFICATION, AND PROPERTIES

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Substrate routes to the buried active site may vary among cytochromes P450: mutagenesis of the F-G region in P450 2B1.

21 June 2018

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Comparison of the dynamics of substrate access channels in three cytochrome P450s reveals different opening mechanisms and a novel functional role for a buried arginine

21 June 2018

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21 June 2018

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21 June 2018

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The catalytic pathway of cytochrome p450cam at atomic resolution

21 June 2018

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The structure of the cytochrome p450BM-3 haem domain complexed with the fatty acid substrate, palmitoleic acid

21 June 2018

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Escherichia coli expression of site-directed mutants of cytochrome P450 2B1 from six substrate recognition sites: substrate specificity and inhibitor selectivity studies

21 June 2018

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High-resolution crystal structure of cytochrome P450cam

21 June 2018

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Flexibility of human cytochromes P450: molecular dynamics reveals differences between CYPs 3A4, 2C9, and 2A6, which correlate with their substrate preferences

21 June 2018

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Mapping of cytochrome P450 2B4 substrate binding sites by photolabile probe 3-azidiamantane: identification of putative substrate access regions.

30 October 2018

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Conformational flexibility of mammalian cytochrome P450 2B4 in binding imidazole inhibitors with different ring chemistry and side chains. Solution thermodynamics and molecular modeling

30 October 2018

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Improvement in the expression of CYP2B6 by co-expression with molecular chaperones GroES/EL in Escherichia coli

30 October 2018

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Possible pathway(s) of testosterone egress from the active site of cytochrome P450 2B1: a steered molecular dynamics simulation.

30 October 2018

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Directed evolution of mammalian cytochrome P450 2B1: mutations outside of the active site enhance the metabolism of several substrates, including the anticancer prodrugs cyclophosphamide and ifosfamide

30 October 2018

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30 October 2018

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Structural and functional diversity in heme monooxygenases

30 October 2018

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Allosteric mechanisms in P450eryF probed with 1-pyrenebutanol, a novel fluorescent substrate

30 October 2018

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A truncation of 2B subfamily cytochromes P450 yields increased expression levels, increased solubility, and decreased aggregation while retaining function

30 October 2018

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Functional interaction between amino-acid residues 242 and 290 in cytochromes P-450 2B1 and 2B11.

30 October 2018

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Thermodynamic studies of substrate binding and spin transitions in human cytochrome P-450 3A4 expressed in yeast microsomes.

30 October 2018

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High-pressure-induced transitions in microsomal cytochrome P450 2B4 in solution: evidence for conformational inhomogeneity in the oligomers.

30 October 2018

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The 2.6-A crystal structure of Pseudomonas putida cytochrome P-450

30 October 2018

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PubMed

https://pubmed.ncbi.nlm.nih.gov/24445070

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Variable path length and counter-flow continuous variation methods for the study of the formation of high-affinity complexes by absorbance spectroscopy. An application to the studies of substrate binding in cytochrome P450

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24445070

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.ABB.2014.01.008

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24445070%20AND%20SRC:MED&resulttype=core&format=json

5 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24445070%20AND%20SRC:MED&resulttype=core&format=json

5 March 2020

PubMed publication ID

24445070

1 reference