Structural basis for ligand promiscuity in cytochrome P450 3A4. (Q35025071)

5 August 2017

Structural basis for ligand promiscuity in cytochrome P450 3A4. (English)

1 reference

5 August 2017

Marika Ekroos

1

1 reference

PubMed ID

16954191

5 August 2017

Tove Sjögren

series ordinal

2

1 reference

PubMed ID

16954191

5 August 2017

language of work or name

English

0 references

publication date

5 September 2006

1 reference

Proceedings of the National Academy of Sciences of the United States of America

5 August 2017

1 reference

5 August 2017

103

1 reference

5 August 2017

13682-13687

1 reference

5 August 2017

37

1 reference

Structure of microsomal cytochrome P450 2B4 complexed with the antifungal drug bifonazole: insight into P450 conformational plasticity and membrane interaction.

5 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1564212

Structures of human microsomal cytochrome P450 2A6 complexed with coumarin and methoxsalen

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1564212

Non-Michaelis-Menten kinetics in cytochrome P450-catalyzed reactions

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1564212

Structures of cytochrome P450 3A4.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1564212

Refinement of severely incomplete structures with maximum likelihood in BUSTER-TNT

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1564212

Crystal structures of human cytochrome P450 3A4 bound to metyrapone and progesterone

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1564212

The structure of human cytochrome P450 2C9 complexed with flurbiprofen at 2.0-A resolution

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1564212

Structure of mammalian cytochrome P450 2B4 complexed with 4-(4-chlorophenyl)imidazole at 1.9-A resolution: insight into the range of P450 conformations and the coordination of redox partner binding

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1564212

Structure of human microsomal cytochrome P450 2C8. Evidence for a peripheral fatty acid binding site

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1564212

An open conformation of mammalian cytochrome P450 2B4 at 1.6-Å resolution

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1564212

Factors affecting the clinical development of cytochrome p450 3A substrates

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1564212

Crystal structure of human cytochrome P450 2C9 with bound warfarin

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1564212

Multisite kinetic models for CYP3A4: simultaneous activation and inhibition of diazepam and testosterone metabolism.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1564212

Ketoconazole-induced conformational changes in the active site of cytochrome P450eryF

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1564212

Mammalian microsomal cytochrome P450 monooxygenase: structural adaptations for membrane binding and functional diversity

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1564212

Integration of macromolecular diffraction data

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1564212

Automated protein model building combined with iterative structure refinement

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1564212

Efficient anisotropic refinement of macromolecular structures using FFT

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1564212

Analysis of human cytochrome P450 3A4 cooperativity: construction and characterization of a site-directed mutant that displays hyperbolic steroid hydroxylation kinetics

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1564212

Solid-state investigations of erythromycin A dihydrate: structure, NMR spectroscopy, and hygroscopicity

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1564212

High-resolution crystal structure of cytochrome P450cam

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1564212

Improved methods for building protein models in electron density maps and the location of errors in these models

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1564212

The structure of human microsomal cytochrome P450 3A4 determined by X-ray crystallography to 2.05-A resolution

8 July 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0603236103

Conformational heterogeneity of cytochrome P450 3A4 revealed by high pressure spectroscopy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0603236103

Analysis of homotropic and heterotropic cooperativity of diazepam oxidation by CYP3A4 using site-directed mutagenesis and kinetic modeling

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0603236103

Cooperative binding of midazolam with testosterone and alpha-naphthoflavone within the CYP3A4 active site: a NMR T1 paramagnetic relaxation study

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0603236103

LIGSITE: automatic and efficient detection of potential small molecule-binding sites in proteins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0603236103

A genetic algorithm for the identification of conformationally invariant regions in protein molecules

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0603236103

Allosteric behavior in cytochrome p450-dependent in vitro drug-drug interactions: a prospective based on conformational dynamics

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/16954191

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Differential mechanisms of cytochrome P450 inhibition and activation by alpha-naphthoflavone

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/16954191

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1073/PNAS.0603236103

1 reference

5 August 2017

0 references

1 reference

5 August 2017

1 reference

PubMed ID

16954191