Granuloma formation and host defense in chronic Mycobacterium tuberculosis infection requires PYCARD/ASC but not NLRP3 or caspase-1. (Q33680440)

28 July 2017

Granuloma formation and host defense in chronic Mycobacterium tuberculosis infection requires PYCARD/ASC but not NLRP3 or caspase-1. (English)

1 reference

Mycobacterium tuberculosis

28 July 2017

0 references

Jessica R McCann

5

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author name string

Erin McElvania Tekippe

1

1 reference

28 July 2017

Irving C Allen

2

1 reference

28 July 2017

Paul D Hulseberg

3

1 reference

28 July 2017

Jonathan T Sullivan

4

1 reference

28 July 2017

Matyas Sandor

6

1 reference

28 July 2017

Miriam Braunstein

7

1 reference

28 July 2017

Jenny P-Y Ting

8

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28 July 2017

language of work or name

English

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publication date

20 August 2010

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28 July 2017

1 reference

28 July 2017

5

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28 July 2017

8

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28 July 2017

e12320

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Creative Commons Attribution 4.0 International

28 July 2017

start time

20 August 2010

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

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cites work

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Caspase-1 independent IL-1beta production is critical for host resistance to mycobacterium tuberculosis and does not require TLR signaling in vivo

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14 July 2018

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NLRs at the intersection of cell death and immunity

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The inflammasome recognizes cytosolic microbial and host DNA and triggers an innate immune response

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NLR, the nucleotide-binding domain leucine-rich repeat containing gene family

14 July 2018

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NLRX1 is a regulator of mitochondrial antiviral immunity

14 July 2018

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Microbial pathogen-induced necrotic cell death mediated by the inflammasome components CIAS1/cryopyrin/NLRP3 and ASC.

14 July 2018

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The pyroptosome: a supramolecular assembly of ASC dimers mediating inflammatory cell death via caspase-1 activation

14 July 2018

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The SecA2 secretion factor of Mycobacterium tuberculosis promotes growth in macrophages and inhibits the host immune response

14 July 2018

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Critical role for Cryopyrin/Nalp3 in activation of caspase-1 in response to viral infection and double-stranded RNA

14 July 2018

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Cutting edge: ASC mediates the induction of multiple cytokines by Porphyromonas gingivalis via caspase-1-dependent and -independent pathways

14 July 2018

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Critical role for NALP3/CIAS1/Cryopyrin in innate and adaptive immunity through its regulation of caspase-1

14 July 2018

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Cryopyrin activates the inflammasome in response to toxins and ATP

14 July 2018

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New insights into the function of granulomas in human tuberculosis

14 July 2018

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Toll-like receptor pathways in the immune responses to mycobacteria

14 July 2018

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Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf

14 July 2018

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The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta

14 July 2018

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The PYRIN-CARD protein ASC is an activating adaptor for caspase-1

14 July 2018

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Mutation of a new gene encoding a putative pyrin-like protein causes familial cold autoinflammatory syndrome and Muckle-Wells syndrome

14 July 2018

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Interleukin-1 signaling is essential for host defense during murine pulmonary tuberculosis

14 July 2018

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ASC, a novel 22-kDa protein, aggregates during apoptosis of human promyelocytic leukemia HL-60 cells

14 July 2018

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Role of interleukin-18 (IL-18) in mycobacterial infection in IL-18-gene-disrupted mice

14 July 2018

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Generation of biologically active IL-1 beta by matrix metalloproteinases: a novel caspase-1-independent pathway of IL-1 beta processing.

14 July 2018

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Progression of chronic pulmonary tuberculosis in mice aerogenically infected with virulent Mycobacterium tuberculosis

14 July 2018

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Lethal tuberculosis in interleukin-6-deficient mutant mice

14 July 2018

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Granzyme A is an interleukin 1 beta-converting enzyme

14 July 2018

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Tumor necrosis factor-alpha is required in the protective immune response against Mycobacterium tuberculosis in mice

14 July 2018

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Altered cytokine export and apoptosis in mice deficient in interleukin-1 beta converting enzyme

14 July 2018

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Cloning of a new cytokine that induces IFN-gamma production by T cells

14 July 2018

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Generation of biologically active interleukin-1 beta by proteolytic cleavage of the inactive precursor.

14 July 2018

1 reference

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Rapid and specific conversion of precursor interleukin 1 beta (IL-1 beta) to an active IL-1 species by human mast cell chymase

14 July 2018

1 reference

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Killing of virulent Mycobacterium tuberculosis by reactive nitrogen intermediates produced by activated murine macrophages

14 July 2018

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Depletion of alveolar macrophages exerts protective effects in pulmonary tuberculosis in mice

14 July 2018

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Crossref

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0012320

Structural deficiencies in granuloma formation in TNF gene-targeted mice underlie the heightened susceptibility to aerosol Mycobacterium tuberculosis infection, which is not compensated for by lymphotoxin.

21 January 2018

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Protective role of interleukin-1 in mycobacterial infection in IL-1 alpha/beta double-knockout mice

30 October 2018

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12 December 2020

Mycobacterium tuberculosis protein ESAT-6 is a potent activator of the NLRP3/ASC inflammasome

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12 December 2020

Control of latent Mycobacterium tuberculosis infection is dependent on CD8 T cells

1 reference

12 December 2020

Role of interleukin (IL)-1 type 1 receptor in mycobacterial infection

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12 December 2020

10.1371/JOURNAL.PONE.0012320

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DOI

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28 July 2017

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28 July 2017

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