Intrinsic TGF-β signaling promotes age-dependent CD8+ T cell polyfunctionality attrition. (Q33685895)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24762437%20AND%20SRC:MED&resulttype=core&format=json

15 March 2020

title

Intrinsic TGF-β signaling promotes age-dependent CD8+ T cell polyfunctionality attrition (English)

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15 March 2020

3

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15 March 2020

Upasana Shokal

6

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15 March 2020

8

Richard A Koup

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15 March 2020

author name string

Rajarshi Bhadra

1

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15 March 2020

Magali M Moretto

2

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15 March 2020

Constantinos Petrovas

4

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15 March 2020

Sara Ferrando-Martinez

5

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15 March 2020

Manuel Leal

7

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Ioannis Eleftherianos

9

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15 March 2020

Imtiaz A Khan

10

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15 March 2020

language of work or name

English

0 references

publication date

24 April 2014

1 reference

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Journal of Clinical Investigation

15 March 2020

published in

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15 March 2020

volume

124

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issue

6

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15 March 2020

page(s)

2441-2455

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The aging immune system: challenges for the 21st century

15 March 2020

cites work

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Transcription factor regulation of CD8+ T-cell memory and exhaustion

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Optimal CD8 T-cell response against Encephalitozoon cuniculi is mediated by Toll-like receptor 4 upregulation by dendritic cells

21 June 2018

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Overcoming the hurdles in using mouse genetic models that block TGF-beta signaling

21 June 2018

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Decrease of Foxp3+ Treg cell number and acquisition of effector cell phenotype during lethal infection

21 June 2018

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Blimp-1/Prdm1 alternative promoter usage during mouse development and plasma cell differentiation

21 June 2018

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A role for the transcriptional repressor Blimp-1 in CD8(+) T cell exhaustion during chronic viral infection.

21 June 2018

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Blimp-1 transcription factor is required for the differentiation of effector CD8(+) T cells and memory responses

21 June 2018

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Transcriptional repressor Blimp-1 promotes CD8(+) T cell terminal differentiation and represses the acquisition of central memory T cell properties

21 June 2018

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TGF-beta and 'adaptive' Foxp3(+) regulatory T cells

21 June 2018

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Cell-intrinsic transforming growth factor-beta signaling mediates virus-specific CD8+ T cell deletion and viral persistence in vivo

21 June 2018

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Opposing effects of TGF-beta and IL-15 cytokines control the number of short-lived effector CD8+ T cells

21 June 2018

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Photorhabdus and a host of hosts

21 June 2018

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The ageing immune system: is it ever too old to become young again?

21 June 2018

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Aging mice exhibit a functional defect in mucosal dendritic cell response against an intracellular pathogen

21 June 2018

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21 June 2018

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IL-7 and IL-15 differentially regulate CD8+ T-cell subsets during contraction of the immune response

21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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Immunization with vaccinia virus induces polyfunctional and phenotypically distinctive CD8(+) T cell responses

21 June 2018

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21 June 2018

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HIV nonprogressors preferentially maintain highly functional HIV-specific CD8+ T cells

21 June 2018

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Newly generated CD4 T cells in aged animals do not exhibit age-related defects in response to antigen

21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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Constitutive Cytokine mRNAs Mark Natural Killer (NK) and NK T Cells Poised for Rapid Effector Function

21 June 2018

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21 June 2018

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21 June 2018

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Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method

21 June 2018

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Epidemiology and unique aspects of aging and infectious diseases

21 June 2018

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TGF-beta autocrine loop regulates cell growth and myogenic differentiation in human rhabdomyosarcoma cells.

21 June 2018

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21 June 2018

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Microsporidiosis: molecular and diagnostic aspects

21 June 2018

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Influence of age on rates of new AIDS-defining diseases and survival in 6546 AIDS patients

21 June 2018

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TGF beta 1 inhibits NF-kappa B/Rel activity inducing apoptosis of B cells: transcriptional activation of I kappa B alpha

21 June 2018

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Hepatic expression of mature transforming growth factor beta 1 in transgenic mice results in multiple tissue lesions

21 June 2018

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Immune gene transcription in Drosophila adult flies infected by entomopathogenic nematodes and their mutualistic bacteria.

21 June 2018

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IL-7 promotes CXCR3 ligand-dependent T cell antitumor reactivity in lung cancer

30 October 2018

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Apoptosis regulators Bim and Fas function concurrently to control autoimmunity and CD8+ T cell contraction

30 October 2018

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Differential costimulation through CD137 (4-1BB) restores proliferation of human virus-specific "effector memory" (CD28(-) CD45RA(HI)) CD8(+) T cells

30 October 2018

1 reference

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The functional heterogeneity of type 1 effector T cells in response to infection is related to the potential for IFN-gamma production.

30 October 2018

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Selective expression of the interleukin 7 receptor identifies effector CD8 T cells that give rise to long-lived memory cells.

30 October 2018

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Intestinal microsporidiosis due to Enterocytozoon bieneusi in elderly human immunodeficiency virus--negative patients from Vigo, Spain

30 October 2018

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Infection with a Helminth Parasite Attenuates Autoimmunity through TGF- -Mediated Suppression of Th17 and Th1 Responses

30 October 2018

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12 December 2020

HIV and aging--preparing for the challenges ahead

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12 December 2020

CD8+ CTLs are essential for protective immunity against Encephalitozoon cuniculi infection

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12 December 2020

Shear activates platelet-derived latent TGF-beta

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12 December 2020

Identifiers

DOI

10.1172/JCI70522

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24762437%20AND%20SRC:MED&resulttype=core&format=json

release_72qwd4u3p5dqhgsjcpncswzcpe

15 March 2020

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/72qwd4u3p5dqhgsjcpncswzcpe

24 November 2022

mapped directly with Wikidata item

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24762437%20AND%20SRC:MED&resulttype=core&format=json

15 March 2020

PubMed publication ID

24762437

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24762437%20AND%20SRC:MED&resulttype=core&format=json