Extreme obesity due to impaired leptin signaling in mice does not cause knee osteoarthritis (Q33691146)

28 July 2017

Extreme obesity due to impaired leptin signaling in mice does not cause knee osteoarthritis (English)

1 reference

28 July 2017

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1 reference

1 reference

Farshid Guilak

4

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Virginia B Kraus

series ordinal

3

object named as

Virginia B Kraus

1 reference

28 July 2017

Timothy M Griffin

1

1 reference

PubMed ID

19790050

28 July 2017

Janet L Huebner

series ordinal

2

1 reference

28 July 2017

1 October 2009

1 reference

28 July 2017

Arthritis & Rheumatology

1 reference

28 July 2017

60

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28 July 2017

10

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28 July 2017

2935-2944

1 reference

Why is obesity associated with osteoarthritis? Insights from mouse models of obesity

28 July 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2829313

Animal models for osteoarthritis: the effect of ovariectomy and estrogen treatment - a systematic approach

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2829313

A role for subchondral bone changes in the process of osteoarthritis; a micro-CT study of two canine models.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2829313

Epigenetic regulation of leptin affects MMP-13 expression in osteoarthritic chondrocytes: possible molecular target for osteoarthritis therapeutic intervention

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2829313

Differential expression of leptin and leptin's receptor isoform (Ob-Rb) mRNA between advanced and minimally affected osteoarthritic cartilage; effect on cartilage metabolism

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2829313

CCR2 modulates inflammatory and metabolic effects of high-fat feeding

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2829313

Proinflammatory cytokines and leptin are increased in serum of prepubertal obese children

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2829313

Leptin regulates chondrocyte differentiation and matrix maturation during endochondral ossification

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2829313

Weight loss reduces knee-joint loads in overweight and obese older adults with knee osteoarthritis.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2829313

Signalling pathway involved in nitric oxide synthase type II activation in chondrocytes: synergistic effect of leptin with interleukin-1

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2829313

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2829313

Delayed resolution of acute inflammation during zymosan-induced arthritis in leptin-deficient mice

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2829313

Leptin deficiency produces contrasting phenotypes in bones of the limb and spine

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2829313

Evidence for a key role of leptin in osteoarthritis

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2829313

Synergistic induction of nitric oxide synthase type II: in vitro effect of leptin and interferon-gamma in human chondrocytes and ATDC5 chondrogenic cells

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2829313

Leptin signaling deficiency impairs humoral and cellular immune responses and attenuates experimental arthritis

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2829313

More knee joint osteoarthritis (OA) in mice after inactivation of one allele of type II procollagen gene but less OA after lifelong voluntary wheel running exercise

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2829313

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2829313

Leptin inhibits bone formation through a hypothalamic relay: a central control of bone mass

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2829313

Contribution of a sedentary lifestyle and inactivity to the etiology of overweight and obesity: current evidence and research issues

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2829313

Body weight, body mass index, and incident symptomatic osteoarthritis of the hand, hip, and knee

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2829313

Leptin deficiency enhances sensitivity to endotoxin-induced lethality.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2829313

Leptin and the regulation of body weight in mammals

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2829313

Leptin modulates the T-cell immune response and reverses starvation-induced immunosuppression

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2829313

Heterozygosity for Lep(ob) or Lep(rdb) affects body composition and leptin homeostasis in adult mice.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2829313

Understanding the relationship between body weight and osteoarthritis.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2829313

Anatomic localization of alternatively spliced leptin receptors (Ob-R) in mouse brain and other tissues.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2829313

Cytokines and inflammation in cartilage degradation.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2829313

The association of body weight, body fatness and body fat distribution with osteoarthritis of the knee: data from the Baltimore Longitudinal Study of Aging

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2829313

Expression and biologic characterization of the murine chemokine KC.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2829313

Effects of the obese gene product on body weight regulation in ob/ob mice

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2829313

Obesity and joint disease

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2829313

Central leptin gene therapy blocks ovariectomy-induced adiposity

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2829313

Differential distribution of adipokines between serum and synovial fluid in patients with osteoarthritis. Contribution of joint tissues to their articular production.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2829313

The effect of body weight on progression of knee osteoarthritis is dependent on alignment

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2829313

Obesity is not associated with increased knee joint torque and power during level walking.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2829313

Subchondral bone of the human knee joint in aging and osteoarthritis.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2829313

Effect of recreational physical activities on the development of knee osteoarthritis in older adults of different weights: The Framingham Study

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2829313

Early onset of reproductive function in normal female mice treated with leptin

30 October 2018

1 reference

12 December 2020

Effects of a high fat diet on the joints of aging mice

1 reference

12 December 2020

Absence of posttraumatic arthritis following intraarticular fracture in the MRL/MpJ mouse

1 reference

12 December 2020

The Role of Knee Alignment in Disease Progression and Functional Decline in Knee Osteoarthritis

1 reference

12 December 2020

Adipose tissue as an endocrine organ

1 reference

12 December 2020

Functional and histological characteristics of skeletal muscle and the effects of leptin in the genetically obese (ob/ob) mouse

1 reference

12 December 2020

Effect of menopausal status on body composition and abdominal fat distribution

1 reference

12 December 2020

Degenerative joint disease in mice fed a high-fat diet at various ages

1 reference

12 December 2020

A comparative analysis of bone and cartilage metabolism in two strains of guinea-pig with varying degrees of naturally occurring osteoarthritis

1 reference

12 December 2020

Functional estrogen receptors in adult articular cartilage: estrogen replacement therapy increases chondrocyte synthesis of proteoglycans and insulin-like growth factor binding protein 2

1 reference

12 December 2020

Adipocytokines in synovial fluid

1 reference

12 December 2020

Identifiers

DOI

10.1002/ART.24854

1 reference

release_7polvs6fg5cgbd4xn4evrmppu4

28 July 2017

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/7polvs6fg5cgbd4xn4evrmppu4

24 November 2022

mapped directly with Wikidata item

PMCID

2829313

1 reference

28 July 2017

1 reference

PubMed ID

19790050