Functional identification of tumor-suppressor genes through an in vivo RNA interference screen in a mouse lymphoma model (Q33693027)

28 July 2017

title

Functional identification of tumor-suppressor genes through an in vivo RNA interference screen in a mouse lymphoma model (English)

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28 July 2017

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11

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28 July 2017

5

Lars Zender

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Cornelius Miething

2

Cornelius Miething

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Johannes Zuber

Johannes Zuber

8

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Michael Wigler

Michael Wigler

9

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Gregory Hannon

13

Gregory J Hannon

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28 July 2017

Anka Bric

1

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28 July 2017

Cornelius Miething

2

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28 July 2017

Carl Uli Bialucha

3

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28 July 2017

Claudio Scuoppo

4

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28 July 2017

Lars Zender

5

1 reference

28 July 2017

Alexander Krasnitz

6

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28 July 2017

Zhenyu Xuan

7

1 reference

28 July 2017

James Hicks

10

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28 July 2017

Michael T Hemann

12

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28 July 2017

Scott Powers

14

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28 July 2017

Scott W Lowe

15

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28 July 2017

publication date

1 October 2009

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28 July 2017

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28 July 2017

volume

16

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28 July 2017

issue

4

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28 July 2017

page(s)

324-335

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(V600E)BRAF is associated with disabled feedback inhibition of RAF-MEK signaling and elevated transcriptional output of the pathway

28 July 2017

cites work

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Loss of Rad51c leads to embryonic lethality and modulation of Trp53-dependent tumorigenesis in mice

21 June 2018

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Distinct thresholds govern Myc's biological output in vivo

21 June 2018

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An oncogenomics-based in vivo RNAi screen identifies tumor suppressors in liver cancer

21 June 2018

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DLC1 is a chromosome 8p tumor suppressor whose loss promotes hepatocellular carcinoma

21 June 2018

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Transcriptional control of human p53-regulated genes

21 June 2018

1 reference

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The human homolog of fission yeast Rad17 is implicated in tumor growth

21 June 2018

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An oncogene-induced DNA damage model for cancer development

21 June 2018

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Oncogenic BRAF induces senescence and apoptosis through pathways mediated by the secreted protein IGFBP7.

21 June 2018

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A functional genetic approach identifies the PI3K pathway as a major determinant of trastuzumab resistance in breast cancer

21 June 2018

1 reference

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Non-transcriptional control of DNA replication by c-Myc

21 June 2018

1 reference

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Resolving RAD51C function in late stages of homologous recombination

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2829755

Irradiation-induced G2/M checkpoint response requires ERK1/2 activation

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2829755

Novel patterns of genome rearrangement and their association with survival in breast cancer

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2829755

Rad17 phosphorylation is required for claspin recruitment and Chk1 activation in response to replication stress

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2829755

Functional proteomics approach to investigate the biological activities of cDNAs implicated in breast cancer

21 June 2018

1 reference

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Aberrant activation of notch signaling in human breast cancer

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2829755

ATM promotes apoptosis and suppresses tumorigenesis in response to Myc.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2829755

Retroviral insertional mutagenesis: past, present and future

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2829755

Second-generation shRNA libraries covering the mouse and human genomes

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2829755

Probing tumor phenotypes using stable and regulated synthetic microRNA precursors

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2829755

Tumor suppressor genetics

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2829755

Genes that mediate breast cancer metastasis to lung

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2829755

Design of a genome-wide siRNA library using an artificial neural network

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2829755

A genetic screen for candidate tumor suppressors identifies REST

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2829755

Gene-expression profiles to predict distant metastasis of lymph-node-negative primary breast cancer

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2829755

Loss of negative regulation by Numb over Notch is relevant to human breast carcinogenesis

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2829755

Multicenter phase II study of the oral MEK inhibitor, CI-1040, in patients with advanced non-small-cell lung, breast, colon, and pancreatic cancer

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2829755

Mutation of the mouse Rad17 gene leads to embryonic lethality and reveals a role in DNA damage-dependent recombination

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2829755

Chk1 is haploinsufficient for multiple functions critical to tumor suppression

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2829755

A two-gene expression ratio predicts clinical outcome in breast cancer patients treated with tamoxifen

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2829755

Suppression of tumorigenesis by the p53 target PUMA

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2829755

In vivo activation of the p53 pathway by small-molecule antagonists of MDM2

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2829755

RTCGD: retroviral tagged cancer gene database

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2829755

Defective double-strand DNA break repair and chromosomal translocations by MYC overexpression

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2829755

Genomic instability and endoreduplication triggered by RAD17 deletion

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2829755

A gene-expression signature as a predictor of survival in breast cancer

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2829755

Angiopoietin-2 displays VEGF-dependent modulation of capillary structure and endothelial cell survival in vivo

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2829755

BLAT—The BLAST-Like Alignment Tool

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2829755

Apoptosis and chemoresistance in transgenic cancer models

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2829755

ATR/ATM-mediated phosphorylation of human Rad17 is required for genotoxic stress responses

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2829755

Multiple Ras-dependent phosphorylation pathways regulate Myc protein stability.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2829755

Chk1 is an essential kinase that is regulated by Atr and required for the G(2)/M DNA damage checkpoint

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2829755

Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2829755

INK4a/ARF mutations accelerate lymphomagenesis and promote chemoresistance by disabling p53.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2829755

Premature senescence involving p53 and p16 is activated in response to constitutive MEK/MAPK mitogenic signaling

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2829755

Senescence of human fibroblasts induced by oncogenic Raf.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2829755

Signals from Ras and Rho GTPases interact to regulate expression of p21Waf1/Cip1.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2829755

Identification of a human homologue of the Schizosaccharomyces pombe rad17+ checkpoint gene

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2829755

DNA-PKcs: a T-cell tumour suppressor encoded at the mouse scid locus

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2829755

Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2829755

Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2829755

Targeted disruption of ATM leads to growth retardation, chromosomal fragmentation during meiosis, immune defects, and thymic lymphoma

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2829755

Involvement of p21ras in activation of extracellular signal-regulated kinase 2.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2829755

Strong time dependence of the 76-gene prognostic signature for node-negative breast cancer patients in the TRANSBIG multicenter independent validation series

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2829755

A biologic definition of Burkitt's lymphoma from transcriptional and genomic profiling.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2829755

Downregulation of RAD17 in head and neck cancer

30 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19800577

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

An epi-allelic series of p53 hypomorphs created by stable RNAi produces distinct tumor phenotypes in vivo

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19800577

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

The c-myc oncogene driven by immunoglobulin enhancers induces lymphoid malignancy in transgenic mice

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19800577

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.CCR.2009.08.015

1 reference

28 July 2017

1 reference

28 July 2017

1 reference