Coumarin metabolism, toxicity and carcinogenicity: relevance for human risk assessment (Q33694867)

28 July 2017

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title

Coumarin metabolism, toxicity and carcinogenicity: relevance for human risk assessment (English)

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28 July 2017

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Lake BG

1

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28 July 2017

language of work or name

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1 April 1999

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Food and Chemical Toxicology

28 July 2017

published in

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28 July 2017

volume

37

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28 July 2017

issue

4

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28 July 2017

page(s)

423-453

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DNA lesions, inducible DNA repair, and cell division: three key factors in mutagenesis and carcinogenesis

28 July 2017

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Inhibition of the mutagenicity of 2-nitrofluorene, 3-nitrofluoranthene and 1-nitropyrene by flavonoids, coumarins, quinones and other phenolic compounds.

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Contribution of CYP1A1 and CYP1A2 to the activation of heterocyclic amines in monkeys and human

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Rapid and sensitive determination of coumarin and 7-hydroxycoumarin and its glucuronide conjugate in urine and plasma by high-performance liquid chromatography

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The utility of multiple-section sampling in the histopathological evaluation of the kidney for carcinogenicity studies

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Studies on the induction of cholangiofibrosis by coumarin in the rat

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Two-year toxicity study on coumarin in the baboon

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Toxic hepatitis due to benzo-pyrone

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7 January 2021

Comparison of the effects of inducers of cytochrome P450 on Mongolian gerbil and rat hepatic microsomal monooxygenase activities

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7 January 2021

Metabolism of coumarin by rat, gerbil and human liver microsomes

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7 January 2021

Species differences in the metabolism and hepatotoxicity of coumarin

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7 January 2021

Species differences in the hepatotoxicity of coumarin: a comparison of rat and Mongolian gerbil

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7 January 2021

O-hydroxyphenylacetaldehyde: a major novel metabolite of coumarin formed by rat, gerbil and human liver microsomes

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Comparison of in vivo and in vitro rat hepatic toxicity of coumarin and methyl analogues, and application of quantitative morphometry to toxicity in vivo

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3-Hydroxylation of coumarin or 4-methylcoumarin by rat-liver microsomes and its induction by 4-methylcoumarin given orally

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7 January 2021

3 The Metabolism and Biological Actions of Coumarins

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Liver response tests. VII. Coumarin metabolism in relation to the inhibition of rat-liver glucose 6-phosphatase.

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Structural requirements for the direct and cytochrome P450-dependent reaction of cyclic alpha,beta-unsaturated carbonyl compounds with glutathione: a study with coumarin and related compounds

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7 January 2021

Metabolism of Coumarin and 4-Methylcoumarin by Rat-Liver Microsomes

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7 January 2021

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Role of persistent, non-genotoxic tissue damage in rodent cancer and relevance to humans

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7 January 2021

Liver response tests. IX. Cytopathological changes in the enlarged but histologically normal rat liver

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7 January 2021

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7 January 2021

[Pathological-anatomical results on the effect of coumarin in animal experiments (author's transl)]

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7 January 2021

Genetic effects of coumarins

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CYP2A6 gene polymorphism and risk of liver cancer and cirrhosis

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A single amino acid substitution (Leu160His) in cytochrome P450 CYP2A6 causes switching from 7-hydroxylation to 3-hydroxylation of coumarin

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Food flavourings and compounds of related structure. II. Subacute and chronic toxicity

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The structure, function, and regulation of cytochrome P450 2A enzymes

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Coumarin mercapturic acid isolated from rat urine indicates metabolic formation of coumarin 3,4-epoxide

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7 January 2021

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7 January 2021

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7 January 2021

Identification of o-hydroxyphenylacetaldehyde as a major metabolite of coumarin in rat hepatic microsomes

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Metabolism of coumarin by precision-cut calf liver slices and calf liver microsomes

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7 January 2021

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7 January 2021

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Goblet and Clara cells of human distal airways: evidence for smoking induced changes in their numbers

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7 January 2021

Differential inhibition of coumarin 7-hydroxylase activity in mouse and human liver microsomes

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7 January 2021

Treatment of advanced malignant melanoma with coumarin and cimetidine: a pilot study

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7 January 2021

Treatment of metastatic renal cell carcinoma with coumarin (1,2-benzopyrone) and cimetidine: a pilot study

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7 January 2021

An updated review of the clinical development of coumarin (1,2-benzopyrone) and 7-hydroxycoumarin

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7 January 2021

Antitumour activity of coumarin and 7-hydroxycoumarin against 7,12-dimethylbenz[a]anthracene-induced rat mammary carcinomas

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7 January 2021

Isolation and characterization of a cytochrome P450 of the IIA subfamily from human liver microsomes

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7 January 2021

Studies in detoxication. 72. The metabolism of coumarin and of o-coumaric acid

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7 January 2021

Studies in detoxication. 71. The metabolism of hydroxycoumarins

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7 January 2021

Identification of the human liver cytochrome P-450 responsible for coumarin 7-hydroxylase activity

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7 January 2021

Analysis of coumarin and its urinary metabolites by high-performance liquid chromatography

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7 January 2021

Coumarin inhibits micronuclei formation induced by benzo(a)pyrene in male but not female ICR mice

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7 January 2021

Mouse steroid 15.alpha.-hydroxylase gene family: identification of type II P-45015.alpha. as coumarin 7-hydroxylase

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7 January 2021

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7 January 2021

Quantification of induction of rat oesophageal, gastric and pancreatic glutathione and glutathione S-transferases by dietary anticarcinogens.

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7 January 2021

Tolerance to multiple doses of the pulmonary toxicant, naphthalene

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7 January 2021

Purification and characterization of two forms of hepatic microsomal cytochrome P450 from untreated cynomolgus monkeys

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7 January 2021

Enzyme induction in the cytochrome P-450 system

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7 January 2021

Monographs on fragrance raw materials

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7 January 2021

Hepatitis A impairs the function of human hepatic CYP2A6 in vivo.

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7 January 2021

Species differences and interindividual variation in liver microsomal cytochrome P450 2A enzymes: effects on coumarin, dicumarol, and testosterone oxidation

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7 January 2021

Coumarin 7-hydroxylase activity in human liver microsomes. Properties of the enzyme and interspecies comparisons

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7 January 2021

Tissue and sex-dependent differences in CYP2A activities in hamsters

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7 January 2021

Effect of inducers of cytochrome P-450 on the metabolism of [3-14C]coumarin by rat hepatic microsomes

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7 January 2021

(3-14C) coumarin distribution in rat tissues after the injection of a single dose

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7 January 2021

Ultrastructure of the Nonciliated Bronchiolar Epithelial (Clara) Cell of Mammalian Lung. III. A Study of Man with Comparison of 15 Mammalian Species

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7 January 2021

Ultrastructure of the Nonciliated Bronchiolar Epithelial (Clara) Cell of Mammalian Lung: I. A Comparison of Rabbit, Guinea Pig, Rat, Hamster, and Mouse

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7 January 2021

Comparison of the toxicity of allyl alcohol, coumarin and menadione in precision-cut rat, guinea-pig, cynomolgus monkey and human liver slices

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7 January 2021

Comparison of the metabolism of 7-ethoxycoumarin and coumarin in precision-cut rat liver and lung slices

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7 January 2021

Metabolism and toxicity of coumarin on cultured human, rat, mouse and rabbit hepatocytes

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7 January 2021

Cytochrome P4502A6 (CYP2A6) expression in human hepatocellular carcinoma

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7 January 2021

Mouse hepatic cytochrome P-450 isozyme induction by 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene, pyrazole, and phenobarbital

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7 January 2021

Immunochemical and catalytical studies on hepatic coumarin 7-hydroxylase in man, rat, and mouse

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7 January 2021

Pharmacokinetics of coumarin and its 7-hydroxy-metabolites upon intravenous and peroral administration of coumarin in man

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7 January 2021

Pilot Study on Bioavailability of Coumarin and 7‐Hydroxycoumarin upon Peroral Administration of Coumarin in a Sustained‐Release Dosage Form

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7 January 2021

Inhibition of the genotoxic effects of heterocyclic amines in human derived hepatoma cells by dietary bioantimutagens

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7 January 2021

Effects of antimutagenic flavourings on SCEs induced by chemical mutagens in cultured Chinese hamster cells

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7 January 2021

Suppressing effect of antimutagenic flavorings on chromosome aberrations induced by UV-light or X-rays in cultured Chinese hamster cells

1 reference

https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900010-1

7 January 2021

Studies on the role of the intestinal microflora in the metabolism of coumarin in rats

1 reference

https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900010-1

7 January 2021

Metabolism of coumarin in man.

1 reference

https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900010-1

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900010-1

7 January 2021

NATURALLY OCCURRING COUMARINS AND RELATED PHYSIOLOGICAL ACTIVITIES.

1 reference

https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900010-1

7 January 2021

CYP3A4 and CYP2A6 activities marked by the metabolism of lignocaine and coumarin in patients with liver and kidney diseases and epileptic patients

1 reference

https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900010-1

7 January 2021

Metabolism of coumarin and 7-ethoxycoumarin by rat, mouse, guinea pig, cynomolgus monkey and human precision-cut liver slices

1 reference

https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900010-1

7 January 2021

Identification of a common chemical signal regulating the induction of enzymes that protect against chemical carcinogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900010-1

7 January 2021

Retroviral mediated expression of human cytochrome P450 2A6 in C3H/10T1/2 cells confers transformability by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK).

1 reference

https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900010-1

7 January 2021

Non-carcinogenic response to coumarin in Syrian golden hamsters

1 reference

https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900010-1

7 January 2021

Chemical mutagenesis testing in Drosophila. VI. Interlaboratory comparison of mutagenicity tests after treatment of larvae.

1 reference

https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900010-1

7 January 2021

Metabolism of [3-14C] coumarin by human liver microsomes

1 reference

https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900010-1

7 January 2021

Sex and strain differences in mouse hepatic microsomal coumarin 7-hydroxylase activity

1 reference

https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900010-1

7 January 2021

The metabolism of (2- 14 C) coumarin and (2- 14 C)-7-hydroxycoumarin in the rat.

1 reference

https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900010-1

7 January 2021

The metabolic fate of [14C]coumarin in baboons

1 reference

https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900010-1

7 January 2021

High-performance liquid chromatography of coumarin and its metabolites

1 reference

https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900010-1

7 January 2021

Does the Delaney Clause of the U.S. Food and Drug laws prevent human cancers?

1 reference

https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900010-1

7 January 2021

THE INFLUENCE OF ENTEROHEPATIC CIRCULATION ON TOXICITY OF DRUGS

1 reference

https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900010-1

7 January 2021

Evaluation of genotoxicity, pathological lesions, and cell proliferation in livers of rats and mice treated with furan

1 reference

https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900010-1

7 January 2021

Genetic variation in coumarin hydroxylase activity in the mouse (Mus musculus).

1 reference

https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900010-1

7 January 2021

The human hepatic cytochromes P450 involved in drug metabolism

1 reference

https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900010-1

7 January 2021

The CYP2A3 gene product catalyzes coumarin 7-hydroxylation in human liver microsomes

1 reference

https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900010-1

7 January 2021

Cytochrome P450 2E1 and 2A6 enzymes as major catalysts for metabolic activation of N-nitrosodialkylamines and tobacco-related nitrosamines in human liver microsomes

1 reference

https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900010-1

7 January 2021

Chemical mutagenesis testing in Drosophila. IV. Results of 45 coded compounds tested for the National Toxicology Program.

1 reference

https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900010-1

7 January 2021

Mechanisms of lung injury by systemically administered chemicals

1 reference

https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900010-1

7 January 2021

Percutaneous absorption and metabolism of Coumarin in human and rat skin.

1 reference

https://api.crossref.org/works/10.1016%2FS0278-6915%2899%2900010-1

7 January 2021

10.1016/S0278-6915(99)00010-1

Identifiers

DOI

1 reference

28 July 2017

1 reference