The human hepatic cytochromes P450 involved in drug metabolism (Q36258518)

13 August 2017

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title

The human hepatic cytochromes P450 involved in drug metabolism (English)

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13 August 2017

Wrighton SA

1

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13 August 2017

Stevens JC

series ordinal

2

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13 August 2017

language of work or name

English

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publication date

1 January 1992

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Critical Reviews in Toxicology

13 August 2017

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13 August 2017

22

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13 August 2017

1-21

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13 August 2017

1

1 reference

The P450 superfamily: update on new sequences, gene mapping, and recommended nomenclature

13 August 2017

1 reference

https://api.crossref.org/works/10.3109%2F10408449209145319

Enzymatic oxidation of xenobiotic chemicals

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408449209145319

Human P-450 genes: evolution, regulation and possible role in carcinogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408449209145319

Purification and characterization of hepatic microsomal cytochrome P-450.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408449209145319

Animal and plant cytochrome P-450 systems

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408449209145319

Characterization of human microsomal cytochrome P-450 enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408449209145319

P450 genes: structure, evolution, and regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408449209145319

Species differences in metabolism and pharmacokinetics: are we close to an understanding?

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408449209145319

Human dioxin-inducible cytochrome P1-450: complementary DNA and amino acid sequence

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408449209145319

Human cytochrome P-450 4 mRNA and gene: part of a multigene family that contains Alu sequences in its mRNA

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408449209145319

Location of regulatory elements responsible for drug induction in the rat cytochrome P-450c gene

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408449209145319

Regulation of the mammalian cytochrome P1-450 (CYP1A1) gene

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408449209145319

Identification of genetically high risk individuals to lung cancer by DNA polymorphisms of the cytochrome P45 0IA1 gene

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408449209145319

Human cytochrome P-450PA (P-450IA2), the phenacetin O-deethylase, is primarily responsible for the hepatic 3-demethylation of caffeine and N-oxidation of carcinogenic arylamines

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408449209145319

A form of cytochrome P450 in man, orthologous to form d in the rat, catalyses the O-deethylation of phenacetin and is inducible by cigarette smoking

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408449209145319

21 January 2018

Human cytochromes P-450.

1 reference

https://api.crossref.org/works/10.3109%2F10408449209145319

Induction of estradiol metabolism by dietary indole-3-carbinol in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408449209145319

Furafylline is a potent and selective inhibitor of cytochrome P450IA2 in man.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408449209145319

Identification of a novel P450 expressed in rat lung: cDNA cloning and sequence, chromosome mapping, and induction by 3-methylcholanthrene

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408449209145319

Two steroid 15 alpha-hydroxylase genes and a homologous gene family in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408449209145319

Posttranscriptional regulation of coumarin 7-hydroxylase induction by xenobiotics in mouse liver: mRNA stabilization by pyrazole.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408449209145319

Immunochemical and catalytical studies on hepatic coumarin 7-hydroxylase in man, rat, and mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408449209145319

The CYP2A3 gene product catalyzes coumarin 7-hydroxylation in human liver microsomes

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408449209145319

Purification and characterization of ethanol-inducible human hepatic cytochrome P-450HLj

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408449209145319

Identification of human cytochromes P-450 analogous to forms induced by phenobarbital and 3-methylcholanthrene in the rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408449209145319

Phenotyping of cytochromes P-450 in human tissues with monoclonal antibodies

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408449209145319

cDNA cloning and sequence and cDNA-directed expression of human P450 IIB1: identification of a normal and two variant cDNAs derived from the CYP2B locus on chromosome 19 and differential expression of the IIB mRNAs in human liver

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408449209145319

A novel human cytochrome P450 gene (P450IIB): chromosomal localization and evidence for alternative splicing

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408449209145319

Characterization of cDNAs, mRNAs, and proteins related to human liver microsomal cytochrome P-450 (S)-mephenytoin 4'-hydroxylase

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408449209145319

Purification of a human liver cytochrome P-450 immunochemically related to several cytochromes P-450 purified from untreated rats

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408449209145319

Metabolism of retinol and retinoic acid by human liver cytochrome P450IIC8

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408449209145319

Cloning and expression of complementary DNAs for multiple members of the human cytochrome P450IIC subfamily

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408449209145319

In vitro inhibition studies of tolbutamide hydroxylase activity of human liver microsomes by azoles, sulphonamides and quinolines

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408449209145319

Tolbutamide hydroxylation by human liver microsomes. Kinetic characterisation and relationship to other cytochrome P-450 dependent xenobiotic oxidations

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408449209145319

Human anti-endoplasmic reticulum autoantibodies appearing in a drug-induced hepatitis are directed against a human liver cytochrome P-450 that hydroxylates the drug

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408449209145319

Genetic polymorphism of human cytochrome P-450 (S)-mephenytoin 4-hydroxylase. Studies with human autoantibodies suggest a functionally altered cytochrome P-450 isozyme as cause of the genetic deficiency

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408449209145319

Genetics of drug transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408449209145319

In vitro metabolism of the biguanide antimalarials in human liver microsomes: evidence for a role of the mephenytoin hydroxylase (P450 MP) enzyme

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408449209145319

Induction of polymorphic 4'-hydroxylation of S-mephenytoin by rifampicin

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408449209145319

Polymorphic hydroxylation of Debrisoquine in man.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408449209145319

Interethnic differences in genetic polymorphism of debrisoquin and mephenytoin hydroxylation between Japanese and Caucasian populations

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408449209145319

Characterization of a human liver cytochrome P-450 involved in the oxidation of debrisoquine and other drugs by using antibodies raised to the analogous rat enzyme

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408449209145319

Human debrisoquine 4-hydroxylase (P450IID1): cDNA and deduced amino acid sequence and assignment of the CYP2D locus to chromosome 22.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408449209145319

Characterization of the common genetic defect in humans deficient in debrisoquine metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408449209145319

Debrisoquine/sparteine hydroxylation genotype and phenotype: analysis of common mutations and alleles of CYP2D6 in a European population

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408449209145319

Hybrid cytochromes P-450 identify a substrate binding domain in P-450IIC5 and P-450IIC4.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408449209145319

Two mutant alleles of the human cytochrome P-450db1 gene (P450C2D1) associated with genetically deficient metabolism of debrisoquine and other drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408449209145319

Genetic polymorphisms of drug metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408449209145319

Codeine O-demethylation co-segregates with polymorphic debrisoquine hydroxylation

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408449209145319

Polymorphic formation of morphine from codeine in poor and extensive metabolizers of dextromethorphan: relationship to the presence of immunoidentified cytochrome P-450IID1.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408449209145319

Codeine increases pain thresholds to copper vapor laser stimuli in extensive but not poor metabolizers of sparteine.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408449209145319

Debrisoquine metabolism and genetic predisposition to lung cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408449209145319

Debrisoquine oxidation phenotype and susceptibility to lung cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408449209145319

Human debrisoquine hydroxylase gene polymorphisms in cancer patients and controls

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408449209145319

Antibodies against human cytochrome P-450db1 in autoimmune hepatitis type II.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408449209145319

Major antigen of liver kidney microsomal autoantibodies in idiopathic autoimmune hepatitis is cytochrome P450db1.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408449209145319

Cytochrome P450IIE1: roles in nitrosamine metabolism and mechanisms of regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408449209145319

Characterization of ethanol-inducible human liver N-nitrosodimethylamine demethylase

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408449209145319

Role of human cytochrome P-450 IIE1 in the oxidation of many low molecular weight cancer suspects

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408449209145319

Inactivation of human liver cytochrome P-450 by the drug methoxsalen and other psoralen derivatives

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408449209145319

Regulation of cytochrome P-450j, a high-affinity N-nitrosodimethylamine demethylase, in rat hepatic microsomes

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408449209145319

Modulation of cytochrome P450 isozymes in human liver, by ethanol and drug intake

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408449209145319

Role of cytochromes P450 in drug metabolism and hepatotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408449209145319

Pregnenolone 16 alpha-carbonitrile-inducible P-450 gene family: gene conversion and differential regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408449209145319

Immunochemical evidence for multiple steroid-inducible hepatic cytochromes P-450 in the rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408449209145319

Regulation of testosterone hydroxylation by rat liver microsomal cytochrome P-450.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408449209145319

Identification of an inducible form of cytochrome P-450 in human liver

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408449209145319

Complete cDNA sequence of a cytochrome P-450 inducible by glucocorticoids in human liver

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408449209145319

Isolation and sequence determination of a cDNA clone related to human cytochrome P-450 nifedipine oxidase

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408449209145319

Human P450PCN1: sequence, chromosome localization, and direct evidence through cDNA expression that P450PCN1 is nifedipine oxidase

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408449209145319

Human liver microsomal steroid metabolism: identification of the major microsomal steroid hormone 6 beta-hydroxylase cytochrome P-450 enzyme

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408449209145319

Cyclosporine metabolism in human liver: identification of a cytochrome P-450III gene family as the major cyclosporine-metabolizing enzyme explains interactions of cyclosporine with other drugs.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408449209145319

Bioactivation of aflatoxin B1 by human liver microsomes: role of cytochrome P450 IIIA enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408449209145319

Role of cytochrome P450IIIA4 in the metabolism of the pyrrolizidine alkaloid senecionine in human liver

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408449209145319

Erythromycin breath test as an assay of glucocorticoid-inducible liver cytochromes P-450. Studies in rats and patients

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408449209145319

Characterization of a cDNA encoding a new member of the glucocorticoid-responsive cytochromes P450 in human liver

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408449209145319

Identification of a cytochrome P-450 in human fetal liver related to glucocorticoid-inducible cytochrome P-450HLp in the adult

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408449209145319

Isolation and characterization of human fetal liver cytochrome P450HLp2: a third member of the P450III gene family

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408449209145319

Purification and properties of cytochrome P-450 from homogenates of human fetal livers.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408449209145319

Occurrence and inducibility of cytochrome P450IIIA in maternal and fetal rats during prenatal development

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408449209145319

Altered estrogen metabolism and excretion in humans following consumption of indole‐3‐carbinol

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408449209145319

Mouse steroid 15.alpha.-hydroxylase gene family: identification of type II P-45015.alpha. as coumarin 7-hydroxylase

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408449209145319

Steroid hormone hydroxylase specificities of eleven cDNA-expressed human cytochrome P450s

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408449209145319

Genotyping of poor metabolisers of debrisoquine by allele-specific PCR amplification

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408449209145319

Metabolic oxidation phenotypes as markers for susceptibility to lung cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10408449209145319

10.3109/10408449209145319

21 January 2018

Identifiers

DOI

1 reference

release_f3fh454atjandmy7cib5552ve4

13 August 2017

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/f3fh454atjandmy7cib5552ve4

mapped directly with Wikidata item

24 November 2022

based on heuristic

1 reference