Kinome-wide RNAi studies in human multiple myeloma identify vulnerable kinase targets, including a lymphoid-restricted kinase, GRK6. (Q33697369)

28 July 2017

title

Kinome-wide RNAi studies in human multiple myeloma identify vulnerable kinase targets, including a lymphoid-restricted kinase, GRK6. (English)

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28 July 2017

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Louise M Perkins

9

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Rodger Tiedemann

object named as

Rodger E Tiedemann

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Rafael Fonseca

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Rafael Fonseca

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author name string

Yuan Xiao Zhu

2

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28 July 2017

Jessica Schmidt

3

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28 July 2017

Hongwei Yin

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28 July 2017

Chang-Xin Shi

5

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28 July 2017

Qiang Que

6

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28 July 2017

Gargi Basu

7

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28 July 2017

David Azorsa

8

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28 July 2017

Esteban Braggio

10

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28 July 2017

P Leif Bergsagel

12

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28 July 2017

Spyro Mousses

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28 July 2017

A Keith Stewart

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28 July 2017

language of work or name

English

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publication date

7 December 2009

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28 July 2017

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28 July 2017

volume

115

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28 July 2017

issue

8

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28 July 2017

page(s)

1594-1604

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Nifuroxazide inhibits survival of multiple myeloma cells by directly inhibiting STAT3.

28 July 2017

cites work

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Ursolic acid inhibits STAT3 activation pathway leading to suppression of proliferation and chemosensitization of human multiple myeloma cells

21 June 2018

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STAT3 as a central mediator of neoplastic cellular transformation

21 June 2018

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Targeting PKC in multiple myeloma: in vitro and in vivo effects of the novel, orally available small-molecule inhibitor enzastaurin (LY317615.HCl).

21 June 2018

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Pyridone 6, a pan-Janus-activated kinase inhibitor, induces growth inhibition of multiple myeloma cells

21 June 2018

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Genome-scale loss-of-function screening with a lentiviral RNAi library

21 June 2018

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Analysis of expression of heat shock protein-90 (HSP90) and the effects of HSP90 inhibitor (17-AAG) in multiple myeloma.

21 June 2018

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Enzastaurin (LY317615), a protein kinase Cbeta inhibitor, inhibits the AKT pathway and induces apoptosis in multiple myeloma cell lines

21 June 2018

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21 June 2018

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21 June 2018

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Perifosine, an oral bioactive novel alkylphospholipid, inhibits Akt and induces in vitro and in vivo cytotoxicity in human multiple myeloma cells

21 June 2018

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Antimyeloma activity of heat shock protein-90 inhibition.

21 June 2018

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FGFR3 as a therapeutic target of the small molecule inhibitor PKC412 in hematopoietic malignancies

21 June 2018

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N-benzoylstaurosporine (PKC412) inhibits Akt kinase inducing apoptosis in multiple myeloma cells

21 June 2018

1 reference

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KSHV-GPCR and CXCR2 transforming capacity and angiogenic responses are mediated through a JAK2-STAT3-dependent pathway

21 June 2018

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A novel mechanism for JAK2 activation by a G protein-coupled receptor, the CCK2R: implication of this signaling pathway in pancreatic tumor models.

21 June 2018

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CHIR-258, a novel, multitargeted tyrosine kinase inhibitor for the potential treatment of t(4;14) multiple myeloma.

21 June 2018

1 reference

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Mcl-1 regulation and its role in multiple myeloma

21 June 2018

1 reference

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Differential functional expression of human myocardial G protein receptor kinases in left ventricular cardiac diseases

21 June 2018

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Improved statistical methods for hit selection in high-throughput screening

21 June 2018

1 reference

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Interleukin-6-dependent gene expression profiles in multiple myeloma INA-6 cells reveal a Bcl-2 family-independent survival pathway closely associated with Stat3 activation

21 June 2018

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Regulation of STAT3 activity by G16-coupled receptors

21 June 2018

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Rho family GTPases are required for activation of Jak/STAT signaling by G protein-coupled receptors

21 June 2018

1 reference

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Parc: a cytoplasmic anchor for p53.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2830764

Defective lymphocyte chemotaxis in beta-arrestin2- and GRK6-deficient mice.

21 June 2018

1 reference

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Large-scale analysis of the human and mouse transcriptomes

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2830764

The AKT kinase is activated in multiple myeloma tumor cells

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2830764

Phosphorylation and desensitization of the human thromboxane receptor-alpha by G protein-coupled receptor kinases

21 June 2018

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G protein coupled receptor signaling through the Src and Stat3 pathway: role in proliferation and transformation

21 June 2018

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The myeloma-associated oncogene fibroblast growth factor receptor 3 is transforming in hematopoietic cells

21 June 2018

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IL-6 up-regulates mcl-1 in human myeloma cells through JAK / STAT rather than ras / MAP kinase pathway

21 June 2018

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21 June 2018

1 reference

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Phosphorylation and desensitization of human endothelin A and B receptors. Evidence for G protein-coupled receptor kinase specificity

21 June 2018

1 reference

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Frequent translocation t(4;14)(p16.3;q32.3) in multiple myeloma is associated with increased expression and activating mutations of fibroblast growth factor receptor 3

21 June 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2830764

Molecular cloning and expression of GRK6. A new member of the G protein-coupled receptor kinase family

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2830764

Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2830764

A novel protein kinase with leucine zipper-like sequences: its catalytic domain is highly homologous to that of protein kinase C

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2830764

A novel orally active small molecule potently induces G1 arrest in primary myeloma cells and prevents tumor growth by specific inhibition of cyclin-dependent kinase 4/6.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2830764

A screen of the complete protein kinase gene family identifies diverse patterns of somatic mutations in human breast cancer.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2830764

Nuclear factor-kappaB and STAT3 are constitutively active in CD138+ cells derived from multiple myeloma patients, and suppression of these transcription factors leads to apoptosis

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2830764

GRK6 deficiency is associated with enhanced CXCR4-mediated neutrophil chemotaxis in vitro and impaired responsiveness to G-CSF in vivo.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2830764

G Protein-coupled Receptor Kinase Interaction with Hsp90 Mediates Kinase Maturation

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2830764

Loss of PTEN expression leading to high Akt activation in human multiple myelomas

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2830764

Molecular Dissection of Hyperdiploid Multiple Myeloma by Gene Expression Profiling

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2830764

Vascular endothelial growth factor triggers signaling cascades mediating multiple myeloma cell growth and migration

30 October 2018

1 reference

12 December 2020

A phase II study of ZD6474 (Zactima, a selective inhibitor of VEGFR and EGFR tyrosine kinase in patients with relapsed multiple myeloma--NCIC CTG IND.145

1 reference

12 December 2020

MLN120B, a novel IkappaB kinase beta inhibitor, blocks multiple myeloma cell growth in vitro and in vivo

1 reference

12 December 2020

Ectopic expression of fibroblast growth factor receptor 3 promotes myeloma cell proliferation and prevents apoptosis

1 reference

12 December 2020

10.1182/BLOOD-2009-09-243980

Identifiers

DOI

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28 July 2017

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28 July 2017

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