Conditional deletion of p53 and Rb in the renin-expressing compartment of the pancreas leads to a highly penetrant metastatic pancreatic neuroendocrine carcinoma (Q33700895)

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English	Conditional deletion of p53 and Rb in the renin-expressing compartment of the pancreas leads to a highly penetrant metastatic pancreatic neuroendocrine carcinoma	scientific article

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scholarly article

1 reference

28 July 2017

Conditional deletion of p53 and Rb in the renin-expressing compartment of the pancreas leads to a highly penetrant metastatic pancreatic neuroendocrine carcinoma (English)

1 reference

28 July 2017

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author name string

S T Glenn

1

1 reference

28 July 2017

C A Jones

2

1 reference

28 July 2017

S Sexton

3

1 reference

28 July 2017

C M LeVea

4

1 reference

28 July 2017

S M Caraker

5

1 reference

28 July 2017

G Hajduczok

6

1 reference

28 July 2017

K W Gross

7

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28 July 2017

language of work or name

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publication date

2 December 2013

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28 July 2017

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28 July 2017

33

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28 July 2017

5706-5715

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28 July 2017

50

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28 July 2017

https://scigraph.springernature.com/pub.10.1038/onc.2013.514

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Attenuation of the retinoblastoma pathway in pancreatic neuroendocrine tumors due to increased cdk4/cdk6.

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21 June 2018

Intestinal crypt homeostasis results from neutral competition between symmetrically dividing Lgr5 stem cells

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21 June 2018

Gene Amplifications in Well-Differentiated Pancreatic Neuroendocrine Tumors Inactivate the p53 Pathway.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4041964

21 June 2018

Multiple endocrine neoplasia type 1 deletion in pancreatic alpha-cells leads to development of insulinomas in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4041964

21 June 2018

Alpha cell-specific Men1 ablation triggers the transdifferentiation of glucagon-expressing cells and insulinoma development.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4041964

21 June 2018

Pancreatic neurogenin 3-expressing cells are unipotent islet precursors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4041964

21 June 2018

Deciphering von Hippel-Lindau (VHL/Vhl)-associated pancreatic manifestations by inactivating Vhl in specific pancreatic cell populations

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4041964

21 June 2018

Recapitulation of pancreatic neuroendocrine tumors in human multiple endocrine neoplasia type I syndrome via Pdx1-directed inactivation of Men1.

1 reference

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21 June 2018

In vivo analysis of key elements within the renin regulatory region

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4041964

21 June 2018

Histone deacetylase inhibitors modify pancreatic cell fate determination and amplify endocrine progenitors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4041964

21 June 2018

Alpha-cells of the endocrine pancreas: 35 years of research but the enigma remains

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4041964

21 June 2018

The physiology of a local renin-angiotensin system in the pancreas

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4041964

21 June 2018

Broad tumor spectrum in a mouse model of multiple endocrine neoplasia type 1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4041964

21 June 2018

Role of the renin-angiotensin system in the endocrine pancreas: implications for the development of diabetes.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4041964

21 June 2018

Pancreatic islet renin angiotensin system: its novel roles in islet function and in diabetes mellitus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4041964

21 June 2018

Clinical anticancer drug development: targeting the cyclin-dependent kinases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4041964

21 June 2018

Renin cells are precursors for multiple cell types that switch to the renin phenotype when homeostasis is threatened

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4041964

21 June 2018

General method for the modification of different BAC types and the rapid generation of BAC transgenic mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4041964

21 June 2018

Pancreatic beta-cell-specific ablation of the multiple endocrine neoplasia type 1 (MEN1) gene causes full penetrance of insulinoma development in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4041964

21 June 2018

Of mice and MEN1: Insulinomas in a conditional mouse knockout

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4041964

21 June 2018

A local pancreatic renin-angiotensin system: endocrine and exocrine roles

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4041964

21 June 2018

Role of endothelial cells in early pancreas and liver development

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4041964

21 June 2018

The pancreatic renin-angiotensin system: does it play a role in endocrine oncology?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4041964

21 June 2018

The renin-angiotensin system in the endocrine pancreas

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4041964

21 June 2018

Wide spectrum of tumors in knock-in mice carrying a Cdk4 protein insensitive to INK4 inhibitors.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4041964

21 June 2018

Tissue renin-angiotensin system: its expression, localization, regulation and potential role in the pancreas

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4041964

21 June 2018

A mouse model of multiple endocrine neoplasia, type 1, develops multiple endocrine tumors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4041964

21 June 2018

Functional collaboration between different cyclin-dependent kinase inhibitors suppresses tumor growth with distinct tissue specificity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4041964

21 June 2018

Expression of neurogenin3 reveals an islet cell precursor population in the pancreas

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4041964

21 June 2018

Induction of medulloblastomas in p53-null mutant mice by somatic inactivation of Rb in the external granular layer cells of the cerebellum

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4041964

21 June 2018

What have we learned from gene targeting studies for the renin angiotensin system of the kidney?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4041964

21 June 2018

Loss of Cdk4 expression causes insulin-deficient diabetes and Cdk4 activation results in beta-islet cell hyperplasia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4041964

21 June 2018

Role of angiotensin in renal vascular development.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4041964

21 June 2018

Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4041964

21 June 2018

Pancreatic glucagonoma with and without syndrome. Immunocytochemical study of 5 tumour cases and review of the literature

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4041964

21 June 2018

Isolation and characterization of renin-expressing cell lines from transgenic mice containing a renin-promoter viral oncogene fusion construct.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4041964

21 June 2018

Expression of murine renin genes in subcutaneous connective tissue

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4041964

21 June 2018

Evidence for a local angiotensin-generating system and dose-dependent inhibition of glucose-stimulated insulin release by angiotensin II in isolated pancreatic islets

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.514

21 January 2018

Angiotensin II type 2 receptor is critical for the development of human fetal pancreatic progenitor cells into islet-like cell clusters and their potential for transplantation

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.514

21 January 2018

Temporal control of neurogenin3 activity in pancreas progenitors reveals competence windows for the generation of different endocrine cell types.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.514

21 January 2018

Heritable formation of pancreatic beta-cell tumours in transgenic mice expressing recombinant insulin/simian virus 40 oncogenes

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.514

21 January 2018

Synergistic tumor suppressor activity of BRCA2 and p53 in a conditional mouse model for breast cancer.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.514

21 January 2018

Epigenetic alterations in neuroendocrine tumors: methylation of RAS-association domain family 1, isoform A and p16 genes are associated with metastasis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4041964

30 October 2018

Induction of carcinogenesis by concurrent inactivation of p53 and Rb1 in the mouse ovarian surface epithelium.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4041964

30 October 2018

Mice deficient in both p53 and Rb develop tumors primarily of endocrine origin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4041964

30 October 2018

Expression of a renin/GFP transgene in mouse embryonic, extra-embryonic, and adult tissues

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.514

31 March 2020

The tissue renin-angiotensin system in human pancreas

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.514

31 March 2020

Regulation and expression of a renin-angiotensin system in human pancreas and pancreatic endocrine tumours

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.514

31 March 2020

Neuroendocrine tumors of the pancreas

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.514

31 March 2020

Cooperative tumorigenic effects of germline mutations in Rb and p53

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.514

31 March 2020

Heterozygous Men1 mutant mice develop a range of endocrine tumors mimicking multiple endocrine neoplasia type 1

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.514

31 March 2020

Glucagonomas of transgenic mice express a wide range of general neuroendocrine markers and bioactive peptides

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.514

31 March 2020

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10.1038/ONC.2013.514

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28 July 2017

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28 July 2017

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28 July 2017

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