USP15 targets ALK3/BMPR1A for deubiquitylation to enhance bone morphogenetic protein signalling (Q33703833)

28 July 2017

title

USP15 targets ALK3/BMPR1A for deubiquitylation to enhance bone morphogenetic protein signalling (English)

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28 July 2017

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11

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28 July 2017

Janis Vogt

6

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Mazin A Al-Salihi

object named as

Mazin A Al-Salihi

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author name string

Lina Herhaus

1

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28 July 2017

Kevin S Dingwell

3

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28 July 2017

Timothy D Cummins

4

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28 July 2017

Lize Wasmus

5

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28 July 2017

Richard Ewan

7

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28 July 2017

David Bruce

8

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28 July 2017

Thomas Macartney

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28 July 2017

Simone Weidlich

10

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28 July 2017

Gopal P Sapkota

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28 July 2017

publication date

1 May 2014

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28 July 2017

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28 July 2017

volume

4

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28 July 2017

issue

5

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28 July 2017

page(s)

140065

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Protein associated with SMAD1 (PAWS1/FAM83G) is a substrate for type I bone morphogenetic protein receptors and modulates bone morphogenetic protein signalling

28 July 2017

cites work

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OTUB1 enhances TGFβ signalling by inhibiting the ubiquitylation and degradation of active SMAD2/3.

21 June 2018

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USP15 negatively regulates Nrf2 through deubiquitination of Keap1.

21 June 2018

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Fine-tuning BMP7 signalling in adipogenesis by UBE2O/E2-230K-mediated monoubiquitination of SMAD6

21 June 2018

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21 June 2018

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Protein phosphatase 5 modulates SMAD3 function in the transforming growth factor-β pathway

21 June 2018

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USP11 augments TGFβ signalling by deubiquitylating ALK5.

21 June 2018

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Overactive bone morphogenetic protein signaling in heterotopic ossification and Duchenne muscular dystrophy

21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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USP15 stabilizes TGF-β receptor I and promotes oncogenesis through the activation of TGF-β signaling in glioblastoma

21 June 2018

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USP15 is a deubiquitylating enzyme for receptor-activated SMADs

21 June 2018

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Structure of the USP15 N-terminal domains: a β-hairpin mediates close association between the DUSP and UBL domains

21 June 2018

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Distinct autophagosomal-lysosomal fusion mechanism revealed by thapsigargin-induced autophagy arrest

21 June 2018

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TGF-β signal transduction spreading to a wider field: a broad variety of mechanisms for context-dependent effects of TGF-β.

21 June 2018

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USP15 plays an essential role for caspase-3 activation during Paclitaxel-induced apoptosis

21 June 2018

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Smad6 inhibits the transcriptional activity of Tbx6 by mediating its degradation

21 June 2018

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The ubiquitin-specific peptidase USP15 regulates human papillomavirus type 16 E6 protein stability

21 June 2018

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Regulation of TGF-beta signaling by Smad7.

21 June 2018

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Mutations of TGFbeta signaling molecules in human disease

21 June 2018

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The logic of TGFbeta signaling.

21 June 2018

1 reference

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Molecular genetics of axis formation in zebrafish

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4042855

The disparate role of BMP in stem cell biology

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4042855

Bone morphogenetic proteins

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4042855

Dorsal-ventral patterning and neural induction in Xenopus embryos

21 June 2018

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Comparison of 10 serum bone turnover markers in prostate carcinoma patients with bone metastatic spread: diagnostic and prognostic implications.

21 June 2018

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Cooperative inhibition of bone morphogenetic protein signaling by Smurf1 and inhibitory Smads

21 June 2018

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Mechanisms of TGF-beta signaling from cell membrane to the nucleus

21 June 2018

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Bafilomycin A1 prevents maturation of autophagic vacuoles by inhibiting fusion between autophagosomes and lysosomes in rat hepatoma cell line, H-4-II-E cells

21 June 2018

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TGF-beta signalling from cell membrane to nucleus through SMAD proteins

21 June 2018

1 reference

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The TGF-beta family mediator Smad1 is phosphorylated directly and activated functionally by the BMP receptor kinase

21 June 2018

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21 June 2018

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Bone morphogenetic protein-2 converts the differentiation pathway of C2C12 myoblasts into the osteoblast lineage

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4042855

Studies with a Xenopus BMP receptor suggest that ventral mesoderm-inducing signals override dorsal signals in vivo

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4042855

Regional biosynthetic markers in the early amphibian embryo.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4042855

Zebrafish transforming growth factor-β-stimulated clone 22 domain 3 (TSC22D3) plays critical roles in Bmp-dependent dorsoventral patterning via two deubiquitylating enzymes Usp15 and Otud4.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4042855

USP4 is regulated by AKT phosphorylation and directly deubiquitylates TGF-β type I receptor

30 October 2018

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12 December 2020

Bafilomycin A1, a specific inhibitor of vacuolar-type H(+)-ATPase, inhibits acidification and protein degradation in lysosomes of cultured cells

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12 December 2020

Ubiquitin and the control of protein fate in the secretory and endocytic pathways

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12 December 2020

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12 December 2020

Balancing BMP Signaling through Integrated Inputs into the Smad1 Linker

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12 December 2020

Selective inhibitory effects of Smad6 on bone morphogenetic protein type I receptors

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12 December 2020

Transgenic overexpression of USP15 in the heart induces cardiac remodeling in mice

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12 December 2020

Identifiers

DOI

10.1098/RSOB.140065

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28 July 2017

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28 July 2017

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