Matrix metalloproteinase 13-deficient mice are resistant to osteoarthritic cartilage erosion but not chondrocyte hypertrophy or osteophyte development. (Q33706862)

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English	Matrix metalloproteinase 13-deficient mice are resistant to osteoarthritic cartilage erosion but not chondrocyte hypertrophy or osteophyte development.	scientific article

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13 February 2020

Matrix metalloproteinase 13-deficient mice are resistant to osteoarthritic cartilage erosion but not chondrocyte hypertrophy or osteophyte development (English)

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13 February 2020

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Christopher B Little

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13 February 2020

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13 February 2020

Erik W. Thompson

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A Barai

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13 February 2020

D Burkhardt

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13 February 2020

S M Smith

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13 February 2020

Z Werb

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13 February 2020

M Shah

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1 December 2009

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13 February 2020

Arthritis and Rheumatism

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13 February 2020

3723-3733

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13 February 2020

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13 February 2020

Modulating chondrocyte hypertrophy in growth plate and osteoarthritic cartilage.

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21 June 2018

Cartilage degradation is fully reversible in the presence of aggrecanase but not matrix metalloproteinase activity

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21 June 2018

Should subchondral bone turnover be targeted when treating osteoarthritis?

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21 June 2018

Joint diseases and matrix metalloproteinases: a role for MMP-13.

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21 June 2018

ADAMTS-5: the story so far.

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21 June 2018

Role of matrix metalloproteinase 13 in both endochondral and intramembranous ossification during skeletal regeneration

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21 June 2018

Development of musculoskeletal toxicity without clear benefit after administration of PG-116800, a matrix metalloproteinase inhibitor, to patients with knee osteoarthritis: a randomized, 12-month, double-blind, placebo-controlled study

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21 June 2018

Matrix metalloproteinases as modulators of inflammation

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21 June 2018

Discovery and characterization of a novel inhibitor of matrix metalloprotease-13 that reduces cartilage damage in vivo without joint fibroplasia side effects

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21 June 2018

Blocking aggrecanase cleavage in the aggrecan interglobular domain abrogates cartilage erosion and promotes cartilage repair

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21 June 2018

In search of partners: linking extracellular proteases to substrates

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21 June 2018

The roles of substrate thermal stability and P2 and P1' subsite identity on matrix metalloproteinase triple-helical peptidase activity and collagen specificity

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21 June 2018

Expression profiling of metalloproteinases and their inhibitors in synovium and cartilage

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21 June 2018

ADAMTS5 is the major aggrecanase in mouse cartilage in vivo and in vitro

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21 June 2018

Deletion of active ADAMTS5 prevents cartilage degradation in a murine model of osteoarthritis

1 reference

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21 June 2018

Critical roles for collagenase-3 (Mmp13) in development of growth plate cartilage and in endochondral ossification

1 reference

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21 June 2018

Altered endochondral bone development in matrix metalloproteinase 13-deficient mice

1 reference

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21 June 2018

Expression profiling of metalloproteinases and their inhibitors in cartilage

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21 June 2018

Aggrecanases and cartilage matrix degradation

1 reference

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21 June 2018

Postnatal expression in hyaline cartilage of constitutively active human collagenase-3 (MMP-13) induces osteoarthritis in mice

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21 June 2018

Identification and enzymatic characterization of two diverging murine counterparts of human interstitial collagenase (MMP-1) expressed at sites of embryo implantation

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21 June 2018

Mutations in the interglobular domain of aggrecan alter matrix metalloproteinase and aggrecanase cleavage patterns. Evidence that matrix metalloproteinase cleavage interferes with aggrecanase activity

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21 June 2018

Mechanisms involved in cartilage proteoglycan catabolism

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21 June 2018

Collagenase 3 is a target of Cbfa1, a transcription factor of the runt gene family involved in bone formation

1 reference

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21 June 2018

Activation of progelatinase B (proMMP-9) by active collagenase-3 (MMP-13)

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21 June 2018

Enhanced cleavage of type II collagen by collagenases in osteoarthritic articular cartilage

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21 June 2018

The role of the C-terminal domain of human collagenase-3 (MMP-13) in the activation of procollagenase-3, substrate specificity, and tissue inhibitor of metalloproteinase interaction

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21 June 2018

Evidence to suggest that cathepsin K degrades articular cartilage in naturally occurring equine osteoarthritis

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30 October 2018

Contribution of runt-related transcription factor 2 to the pathogenesis of osteoarthritis in mice after induction of knee joint instability.

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30 October 2018

Degradation of small leucine-rich repeat proteoglycans by matrix metalloprotease-13: identification of a new biglycan cleavage site

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30 October 2018

Increased type II collagen degradation and very early focal cartilage degeneration is associated with upregulation of chondrocyte differentiation related genes in early human articular cartilage lesions.

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30 October 2018

Effect of inhibition of matrix metalloproteinases on cartilage loss in vitro and in a guinea pig model of osteoarthritis

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30 October 2018

Aggrecan protects cartilage collagen from proteolytic cleavage.

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30 October 2018

Relative messenger RNA expression profiling of collagenases and aggrecanases in human articular chondrocytes in vivo and in vitro

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30 October 2018

Spatial and temporal localization of transforming growth factor-beta, fibroblast growth factor-2, and osteonectin, and identification of cells expressing alpha-smooth muscle actin in the injured anulus fibrosus: implications for extracellular matrix

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30 October 2018

Proteolysis involving matrix metalloproteinase 13 (collagenase-3) is required for chondrocyte differentiation that is associated with matrix mineralization.

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30 October 2018

Acellular calcified columns in the normal growth plate of mouse vertebrae

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30 October 2018

Chondrocyte hypertrophy can be induced by a cryptic sequence of type II collagen and is accompanied by the induction of MMP-13 and collagenase activity: Implications for development and arthritis

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30 October 2018

Age-related expression patterns of Bag-1 and Bcl-2 in growth plate and articular chondrocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/19950295

12 December 2020

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Regulation of osteoarthritis development by Wnt-beta-catenin signaling through the endochondral ossification process

1 reference

https://pubmed.ncbi.nlm.nih.gov/19950295

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Matrix metalloproteinase-13 influences ERK signalling in articular rabbit chondrocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/19950295

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Selective enhancement of collagenase-mediated cleavage of resident type II collagen in cultured osteoarthritic cartilage and arrest with a synthetic inhibitor that spares collagenase 1 (matrix metalloproteinase 1)

1 reference

https://pubmed.ncbi.nlm.nih.gov/19950295

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Impaired bone fracture healing in matrix metalloproteinase-13 deficient mice

1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Apoptosis and proliferation of growth plate chondrocytes in rabbits

1 reference

https://pubmed.ncbi.nlm.nih.gov/19950295

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

MRI evaluation of growth plate closure rate and pattern in the normal knee joint

1 reference

https://pubmed.ncbi.nlm.nih.gov/19950295

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Metalloproteinase and tissue inhibitor of metalloproteinase expression in the murine STR/ort model of osteoarthritis

1 reference

https://pubmed.ncbi.nlm.nih.gov/19950295

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of collagen and aggrecan genes in normal and osteoarthritic murine knee joints

1 reference

https://pubmed.ncbi.nlm.nih.gov/19950295

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sites of collagenase cleavage and denaturation of type II collagen in aging and osteoarthritic articular cartilage and their relationship to the distribution of matrix metalloproteinase 1 and matrix metalloproteinase 13

1 reference

https://pubmed.ncbi.nlm.nih.gov/19950295

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Osteoarthritis development in novel experimental mouse models induced by knee joint instability

1 reference

https://pubmed.ncbi.nlm.nih.gov/19950295

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Early closure of growth plate causes poor growth of long bones in collagen-induced arthritis rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/19950295

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Anabolic and catabolic gene expression pattern analysis in normal versus osteoarthritic cartilage using complementary DNA-array technology

1 reference

https://pubmed.ncbi.nlm.nih.gov/19950295

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Induction of osteoarthritis in the rat by surgical tear of the meniscus: Inhibition of joint damage by a matrix metalloproteinase inhibitor

1 reference

https://pubmed.ncbi.nlm.nih.gov/19950295

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The surgical destabilization of the medial meniscus (DMM) model of osteoarthritis in the 129/SvEv mouse

1 reference

https://pubmed.ncbi.nlm.nih.gov/19950295

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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10.1002/ART.25002

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13 February 2020

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Europe PubMed Central

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13 February 2020

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Europe PubMed Central

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13 February 2020

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