Two flavonolignans from milk thistle (Silybum marianum) inhibit CYP2C9-mediated warfarin metabolism at clinically achievable concentrations (Q33714834)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19934397%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

title

Two flavonolignans from milk thistle (Silybum marianum) inhibit CYP2C9-mediated warfarin metabolism at clinically achievable concentrations (English)

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19934397%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

0 references

1 reference

2

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12 February 2020

author name string

Scott J Brantley

series ordinal

1

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12 February 2020

David J Kroll

series ordinal

3

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12 February 2020

Mary F Paine

series ordinal

4

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12 February 2020

language of work or name

English

0 references

publication date

24 November 2009

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Journal of Pharmacology and Experimental Therapeutics

12 February 2020

published in

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12 February 2020

volume

332

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12 February 2020

issue

3

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12 February 2020

page(s)

1081-1087

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Warfarin potentiation: a review of the "FAB-4" significant drug interactions

12 February 2020

cites work

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Genetic and clinical factors relating to warfarin dosing

21 June 2018

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Clinical evidence of herb-drug interactions: a systematic review by the natural standard research collaboration.

21 June 2018

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Drug-drug interactions of silymarin on the perspective of pharmacokinetics

21 June 2018

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Multitargeted therapy of cancer by silymarin

21 June 2018

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Clinical assessment of CYP2D6-mediated herb-drug interactions in humans: effects of milk thistle, black cohosh, goldenseal, kava kava, St. John's wort, and Echinacea.

21 June 2018

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Milk thistle nomenclature: why it matters in cancer research and pharmacokinetic studies

21 June 2018

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Advances in the use of milk thistle (Silybum marianum).

21 June 2018

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Silybin and silymarin--new and emerging applications in medicine

21 June 2018

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Clinical relevance of the small intestine as an organ of drug elimination: drug-fruit juice interactions.

21 June 2018

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Anticancer potential of silymarin: from bench to bed side.

21 June 2018

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The pharmocogenomics of warfarin: closing in on personalized medicine

21 June 2018

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Assessing the clinical significance of botanical supplementation on human cytochrome P450 3A activity: comparison of a milk thistle and black cohosh product to rifampin and clarithromycin

21 June 2018

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Effect of milk thistle (Silybum marianum) and black cohosh (Cimicifuga racemosa) supplementation on digoxin pharmacokinetics in humans

21 June 2018

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Herb-drug interactions: a literature review

21 June 2018

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Milk thistle and prostate cancer: differential effects of pure flavonolignans from Silybum marianum on antiproliferative end points in human prostate carcinoma cells.

21 June 2018

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Predicting inhibitory drug-drug interactions and evaluating drug interaction reports using inhibition constants

21 June 2018

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In vivo assessment of botanical supplementation on human cytochrome P450 phenotypes: Citrus aurantium, Echinacea purpurea, milk thistle, and saw palmetto.

21 June 2018

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Effect of silymarin on the pharmacokinetics of losartan and its active metabolite E-3174 in healthy Chinese volunteers

21 June 2018

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Silibinin inhibits established prostate tumor growth, progression, invasion, and metastasis and suppresses tumor angiogenesis and epithelial-mesenchymal transition in transgenic adenocarcinoma of the mouse prostate model mice

30 October 2018

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The pharmacokinetics of silymarin is altered in patients with hepatitis C virus and nonalcoholic Fatty liver disease and correlates with plasma caspase-3/7 activity

30 October 2018

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A phase I and pharmacokinetic study of silybin-phytosome in prostate cancer patients

30 October 2018

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Dietary supplementation with silymarin inhibits 3,2'-dimethyl-4-aminobiphenyl-induced prostate carcinogenesis in male F344 rats

30 October 2018

1 reference

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Silybin inactivates cytochromes P450 3A4 and 2C9 and inhibits major hepatic glucuronosyltransferases

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2835426

Isolation of symlandine from the roots of common comfrey (Symphytum officinale) using countercurrent chromatography

30 October 2018

1 reference

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Gram-Scale Purification of Flavonolignan Diastereoisomers from Silybum marianum (Milk Thistle) Extract in Support of Preclinical in vivo Studies for Prostate Cancer Chemoprevention

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2835426

Pharmacokinetics and metabolic profile of free, conjugated, and total silymarin flavonolignans in human plasma after oral administration of milk thistle extract

30 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19934397

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

A method for identification of inhibition mechanism and estimation of Ki in in vitro enzyme inhibition study

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19934397

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Mechanism-based inactivation of human cytochrome p450 enzymes and the prediction of drug-drug interactions

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19934397

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1124/JPET.109.161927

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19934397%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19934397%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

PubMed publication ID

19934397

1 reference