Dabigatran, a direct thrombin inhibitor, demonstrates antifibrotic effects on lung fibroblasts. (Q33722844)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19877031%20AND%20SRC:MED&resulttype=core&format=json

11 February 2020

title

Dabigatran, a direct thrombin inhibitor, demonstrates antifibrotic effects on lung fibroblasts (English)

1 reference

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11 February 2020

1 reference

Anna Ludwicka-Bradley

series ordinal

2

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19877031%20AND%20SRC:MED&resulttype=core&format=json

11 February 2020

author name string

Galina S Bogatkevich

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19877031%20AND%20SRC:MED&resulttype=core&format=json

11 February 2020

Richard M Silver

series ordinal

3

1 reference

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11 February 2020

publication date

1 November 2009

1 reference

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11 February 2020

published in

Arthritis and Rheumatism

1 reference

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11 February 2020

volume

60

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11 February 2020

issue

11

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11 February 2020

page(s)

3455-3464

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Clinical pharmacokinetics and pharmacodynamics of the oral direct thrombin inhibitor dabigatran etexilate

11 February 2020

cites work

1 reference

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Endothelin-1 promotes myofibroblast induction through the ETA receptor via a rac/phosphoinositide 3-kinase/Akt-dependent pathway and is essential for the enhanced contractile phenotype of fibrotic fibroblasts.

21 June 2018

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Combinatorial signaling pathways determine fibroblast proliferation and myofibroblast differentiation

21 June 2018

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21 June 2018

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Role of thrombin and its major cellular receptor, protease-activated receptor-1, in pulmonary fibrosis

21 June 2018

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The NH2-terminal peptide of alpha-smooth muscle actin inhibits force generation by the myofibroblast in vitro and in vivo

21 June 2018

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Thrombin differentiates normal lung fibroblasts to a myofibroblast phenotype via the proteolytically activated receptor-1 and a protein kinase C-dependent pathway

21 June 2018

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21 June 2018

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Thrombin is a potent inducer of connective tissue growth factor production via proteolytic activation of protease-activated receptor-1.

21 June 2018

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Signal transduction pathways activated during fibroblast contraction of collagen matrices

21 June 2018

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Thrombin stimulates fibroblast procollagen production via proteolytic activation of protease-activated receptor 1

21 June 2018

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alpha-Thrombin induces transforming growth factor-beta1 mRNA and protein in cultured vascular smooth muscle cells via a proteolytically activated receptor

21 June 2018

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21 June 2018

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Scleroderma bronchoalveolar lavage fluid contains thrombin, a mediator of human lung fibroblast proliferation via induction of platelet-derived growth factor alpha-receptor

21 June 2018

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Inhibition of connective tissue growth factor by small interfering RNA prevents renal fibrosis in rats undergoing chronic allograft nephropathy

21 June 2018

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Interstitial lung disease associated with systemic sclerosis: what is the evidence for efficacy of cyclophosphamide?

30 October 2018

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Impairment of the antifibrotic effect of hepatocyte growth factor in lung fibroblasts from African Americans: possible role in systemic sclerosis.

30 October 2018

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Population pharmacokinetic analysis of the new oral thrombin inhibitor dabigatran etexilate (BIBR 1048) in patients undergoing primary elective total hip replacement surgery.

30 October 2018

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TGF-beta and CTGF have overlapping and distinct fibrogenic effects on human renal cells

30 October 2018

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Direct thrombin inhibition reduces lung collagen, accumulation, and connective tissue growth factor mRNA levels in bleomycin-induced pulmonary fibrosis.

30 October 2018

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30 October 2018

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12 December 2020

Depletion of protein kinase Cepsilon in normal and scleroderma lung fibroblasts has opposite effects on tenascin expression

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12 December 2020

Contractile activity and smooth muscle alpha-actin organization in thrombin-induced human lung myofibroblasts

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12 December 2020

Growth and characterization of fibroblasts obtained from bronchoalveolar lavage of patients with scleroderma

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12 December 2020

Myofibroblast induction and microvascular alteration in scleroderma lung fibrosis

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12 December 2020

Connective tissue growth factor causes persistent proalpha2(I) collagen gene expression induced by transforming growth factor-beta in a mouse fibrosis model

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12 December 2020

In-vitro profile and ex-vivo anticoagulant activity of the direct thrombin inhibitor dabigatran and its orally active prodrug, dabigatran etexilate

1 reference

12 December 2020

Interstitial lung disease in systemic sclerosis

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12 December 2020

Thrombin induces endothelin expression in arterial smooth muscle cells

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12 December 2020

Identifiers

DOI

10.1002/ART.24935

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19877031%20AND%20SRC:MED&resulttype=core&format=json

11 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19877031%20AND%20SRC:MED&resulttype=core&format=json

11 February 2020

1 reference