Safety, tolerability, pharmacokinetics, and activity of the novel long-acting antimalarial DSM265: a two-part first-in-human phase 1a/1b randomised study (Q33732740)

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English	Safety, tolerability, pharmacokinetics, and activity of the novel long-acting antimalarial DSM265: a two-part first-in-human phase 1a/1b randomised study	scientific article

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scholarly article

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Europe PubMed Central

29 July 2017

Safety, tolerability, pharmacokinetics, and activity of the novel long-acting antimalarial DSM265: a two-part first-in-human phase 1a/1b randomised study (English)

1 reference

Europe PubMed Central

29 July 2017

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pharmacokinetics

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based on heuristic

inferred from title

James S McCarthy

1

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4 June 2020

8

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4 June 2020

David A. Fidock

10

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4 June 2020

Margaret A. Phillips

5

object named as

Margaret A Phillips

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4 June 2020

author name string

Julie Lotharius

2

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4 June 2020

Thomas Rückle

3

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4 June 2020

Stephan Chalon

4

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4 June 2020

Suzanne Elliott

6

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4 June 2020

Silvana Sekuloski

7

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4 June 2020

Caroline L Ng

9

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4 June 2020

Louise Marquart

11

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4 June 2020

Noelle S Williams

12

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4 June 2020

Nathalie Gobeau

13

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4 June 2020

Lidiya Bebrevska

14

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4 June 2020

Maria Rosario

15

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4 June 2020

Kennan Marsh

16

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4 June 2020

Jörg J Möhrle

17

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4 June 2020

publication date

28 March 2017

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29 July 2017

Lancet Infectious Diseases

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4 June 2020

17

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4 June 2020

6

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4 June 2020

626-635

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4 June 2020

New developments in anti-malarial target candidate and product profiles

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A surrogate marker of piperaquine-resistant Plasmodium falciparum malaria: a phenotype-genotype association study

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14 July 2018

Genetic markers associated with dihydroartemisinin-piperaquine failure in Plasmodium falciparum malaria in Cambodia: a genotype-phenotype association study

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Antimalarial Activity of KAF156 in Falciparum and Vivax Malaria

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A Phase II pilot trial to evaluate safety and efficacy of ferroquine against early Plasmodium falciparum in an induced blood-stage malaria infection study

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Defining the Effectiveness of Antimalarial Chemotherapy: Investigation of the Lag in Parasite Clearance Following Drug Administration

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14 July 2018

Piperaquine Monotherapy of Drug-Susceptible Plasmodium falciparum Infection Results in Rapid Clearance of Parasitemia but Is Followed by the Appearance of Gametocytemia.

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14 July 2018

Linking Murine and Human Plasmodium falciparum Challenge Models in a Translational Path for Antimalarial Drug Development

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14 July 2018

Antimalarial activity of artefenomel (OZ439), a novel synthetic antimalarial endoperoxide, in patients with Plasmodium falciparum and Plasmodium vivax malaria: an open-label phase 2 trial

1 reference

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14 July 2018

Ferroquine and artesunate in African adults and children with Plasmodium falciparum malaria: a phase 2, multicentre, randomised, double-blind, dose-ranging, non-inferiority study

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14 July 2018

A long-duration dihydroorotate dehydrogenase inhibitor (DSM265) for prevention and treatment of malaria

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14 July 2018

Evidence of Plasmodium falciparum Malaria Multidrug Resistance to Artemisinin and Piperaquine in Western Cambodia: Dihydroartemisinin-Piperaquine Open-Label Multicenter Clinical Assessment

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14 July 2018

Evaluating the pharmacodynamic effect of antimalarial drugs in clinical trials by quantitative PCR

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14 July 2018

Dihydroartemisinin-piperaquine failure associated with a triple mutant including kelch13 C580Y in Cambodia: an observational cohort study

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14 July 2018

Quantification of female and male Plasmodium falciparum gametocytes by reverse transcriptase quantitative PCR.

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14 July 2018

Direct evidence for the atovaquone action on the Plasmodium cytochrome bc1 complex

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14 July 2018

Spiroindolone KAE609 for falciparum and vivax malaria

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14 July 2018

Sulfadoxine-pyrimethamine resistance in Plasmodium falciparum: a zoomed image at the molecular level within a geographic context

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14 July 2018

A pilot randomised trial of induced blood-stage Plasmodium falciparum infections in healthy volunteers for testing efficacy of new antimalarial drugs

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14 July 2018

A real-time, quantitative PCR method using hydrolysis probes for the monitoring of Plasmodium falciparum load in experimentally infected human volunteers

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14 July 2018

Combination therapy for malaria: the way forward?

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14 July 2018

Optimal dose finding for novel antimalarial combination therapy

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30 October 2018

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12 December 2020

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10.1016/S1473-3099(17)30171-8

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4 June 2020

1 reference

Europe PubMed Central

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4 June 2020

1 reference

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4 June 2020

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