In vivo analysis of the molecular pathogenesis of acute promyelocytic leukemia in the mouse and its therapeutic implications (Q33739259)

29 July 2017

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title

In vivo analysis of the molecular pathogenesis of acute promyelocytic leukemia in the mouse and its therapeutic implications (English)

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acute promyelocytic leukemia

29 July 2017

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He LZ

1

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29 July 2017

Merghoub T

series ordinal

2

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29 July 2017

Pandolfi PP

series ordinal

3

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29 July 2017

language of work or name

English

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publication date

1 September 1999

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29 July 2017

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29 July 2017

18

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29 July 2017

38

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29 July 2017

5278-5292

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https://scigraph.springernature.com/pub.10.1038/sj.onc.1203088

29 July 2017

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cites work

Expression pattern of the RAR alpha-PML fusion gene in acute promyelocytic leukemia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203088

The POZ domain: a conserved protein-protein interaction motif

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203088

A PMLRARalpha transgene initiates murine acute promyelocytic leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203088

Failure of embryonic hematopoiesis and lethal hemorrhages in mouse embryos heterozygous for a knocked-in leukemia gene CBFB-MYH11.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203088

Characterization of a Fusion cDNA (RARA/myl) Transcribed from the t(15;17) Translocation Breakpoint in Acute Promyelocytic Leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203088

Rearrangements of the retinoic acid receptor alpha and promyelocytic leukemia zinc finger genes resulting from t(11;17)(q23;q21) in a patient with acute promyelocytic leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203088

Distinct leukemia phenotypes in transgenic mice and different corepressor interactions generated by promyelocytic leukemia variant fusion genes PLZF-RARalpha and NPM-RARalpha

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1203088

Transgenic expression of PML/RARalpha impairs myelopoiesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203088

The nuclear matrix protein, numatrin (B23), is associated with growth factor-induced mitogenesis in Swiss 3T3 fibroblasts and with T lymphocyte proliferation stimulated by lectins and anti-T cell antigen receptor antibody

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203088

NuMA is required for the organization of microtubules into aster-like mitotic arrays.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203088

Characterization of a Zinc Finger Gene Disrupted by the t(15;17) in Acute Promyelocytic Leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203088

Fusion proteins of the retinoic acid receptor-alpha recruit histone deacetylase in promyelocytic leukaemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203088

Early myeloid cell-specific expression of the human cathepsin G gene in transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203088

Histone acetylation in chromatin structure and transcription

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1203088

Distinct interactions of PML-RARalpha and PLZF-RARalpha with co-repressors determine differential responses to RA in APL.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203088

Acute leukemia with promyelocytic features in PML/RARalpha transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203088

Acute leukaemia in bcr/abl transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203088

Chromosomal translocation t(15;17) in human acute promyelocytic leukemia fuses RARα with a novel putative transcription factor, PML

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203088

Identification of three major sentrinization sites in PML

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1203088

Site-specific recombinases: tools for genome engineering.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203088

Retinoic acid, but not arsenic trioxide, degrades the PLZF/RARalpha fusion protein, without inducing terminal differentiation or apoptosis, in a RA-therapy resistant t(11;17)(q23;q21) APL patient

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203088

bcl-2 inhibits apoptosis of neutrophils but not their engulfment by macrophages

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203088

Retinoic acid and arsenic synergize to eradicate leukemic cells in a mouse model of acute promyelocytic leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203088

Cre-mediated chromosome loss in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203088

Sequence-specific DNA binding and transcriptional regulation by the promyelocytic leukemia zinc finger protein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203088

Role of the histone deacetylase complex in acute promyelocytic leukaemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203088

Formation of nucleophosmin/B23 oligomers requires both the amino- and the carboxyl-terminal domains of the protein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203088

Oncogenic transcription factors in the human acute leukemias

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203088

Identification and preliminary characterization of a protein motif related to the zinc finger

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1203088

High postnatal lethality and testis degeneration in retinoic acid receptor alpha mutant mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203088

Overlapping cDNA clones define the complete coding region for the P210c-abl gene product associated with chronic myelogenous leukemia cells containing the Philadelphia chromosome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203088

PML, a growth suppressor disrupted in acute promyelocytic leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203088

Potentiation of retinoid-induced differentiation of HL-60 and U937 cell lines by cytokines

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203088

Long-range disruption of gene expression by a selectable marker cassette

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203088

PML induces a novel caspase-independent death process

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203088

Chromosomal translocations in human cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203088

Chromosome engineering in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203088

A novel zinc finger coiled-coil domain in a family of nuclear proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203088

A class of hybrid polar inducers of transformed cell differentiation inhibits histone deacetylases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203088

Inducible gene targeting in mice using the Cre/lox system

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203088

The promyelocytic leukemia zinc finger protein affects myeloid cell growth, differentiation, and apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203088

Arsenic trioxide as an inducer of apoptosis and loss of PML/RAR alpha protein in acute promyelocytic leukemia cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203088

The RAR alpha-PLZF chimera associated with Acute Promyelocytic Leukemia has retained a sequence-specific DNA-binding domain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203088

A site-directed chromosomal translocation induced in embryonic stem cells by Cre-loxP recombination.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203088

Retinoids in cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203088

Complete remission after treatment of acute promyelocytic leukemia with arsenic trioxide

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203088

All-trans-retinoic acid in acute promyelocytic leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203088

Cre-mediated site-specific translocation between nonhomologous mouse chromosomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203088

Role of PML in cell growth and the retinoic acid pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203088

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203088

Therapeutic targeting of transcription in acute promyelocytic leukemia by use of an inhibitor of histone deacetylase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203088

Retinoic acid regulates aberrant nuclear localization of PML-RAR alpha in acute promyelocytic leukemia cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203088

Fusion of retinoic acid receptor alpha to NuMA, the nuclear mitotic apparatus protein, by a variant translocation in acute promyelocytic leukaemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203088

Embryonic lethality and impairment of haematopoiesis in mice heterozygous for an AML1-ETO fusion gene.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203088

Leukemia translocation protein PLZF inhibits cell growth and expression of cyclin A.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203088

Cre-loxP-mediated gene replacement: a mouse strain producing humanized antibodies

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203088

Fused transcript of abl and bcr genes in chronic myelogenous leukaemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203088

Review: molecular biology of transgenic animals.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203088

7 January 2021

The acute promyelocytic leukemia PML-RAR alpha protein induces hepatic preneoplastic and neoplastic lesions in transgenic mice

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203088

7 January 2021

The PML-RARα fusion mRNA generated by the t(15;17) translocation in acute promyelocytic leukemia encodes a functionally altered RAR

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203088

7 January 2021

Increased fetal hemoglobin in patients receiving sodium 4-phenylbutyrate

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203088

7 January 2021

Differentiation therapy for acute promyelocytic leukemia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203088

7 January 2021

Independent control of immunoglobulin switch recombination at individual switch regions evidenced through Cre-loxP-mediated gene targeting

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203088

7 January 2021

Humanbcr-abl gene has a lethal effect on embryogenesis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203088

7 January 2021

Engineering chromosomes in mice through targeted meiotic recombination (TAMERE)

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203088

7 January 2021

Restoration of all-trans retinoic acid sensitivity by interferon in acute promyelocytic leukaemia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203088

7 January 2021

A NEW, EXTINCT PLEISTOCENE REEF CORAL FROM THE MONTASTRAEA “ANNULARIS” SPECIES COMPLEX

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203088

7 January 2021

PMLRAR homodimers: distinct DNA binding properties and heteromeric interactions with RXR

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203088

7 January 2021

Persistence of RAR alpha-PML fusion mRNA detected by reverse transcriptase polymerase chain reaction in patients in long-term remission of acute promyelocytic leukaemia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203088

7 January 2021

PML is essential for multiple apoptotic pathways

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1203088

7 January 2021

Acute promyelocytic leukemia

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1203088

7 January 2021

Differentiation Therapy of Acute Promyelocytic Leukemia with Tretinoin (All-trans-Retinoic Acid)

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203088

7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1203088

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Dimensions Publication ID

29 July 2017

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