Failure of embryonic hematopoiesis and lethal hemorrhages in mouse embryos heterozygous for a knocked-in leukemia gene CBFB-MYH11. (Q48860347)

16 February 2018

title

Failure of embryonic hematopoiesis and lethal hemorrhages in mouse embryos heterozygous for a knocked-in leukemia gene CBFB-MYH11. (English)

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16 February 2018

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Francis Collins

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object named as

Collins FS

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author name string

Castilla LH

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Wang Q

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Stacy T

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Speck NA

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Eckhaus M

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Marín-Padilla M

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Wynshaw-Boris A

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Liu PP

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language of work or name

English

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publication date

1 November 1996

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16 February 2018

published in

Cell

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volume

87

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issue

4

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page(s)

687-696

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An Mll-AF9 fusion gene made by homologous recombination causes acute leukemia in chimeric mice: a method to create fusion oncogenes

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c-Myb and core-binding factor/PEBP2 display functional synergy but bind independently to adjacent sites in the T-cell receptor delta enhancer

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Association of an inversion of chromosome 16 with abnormal marrow eosinophils in acute myelomonocytic leukemia. A unique cytogenetic-clinicopathological association

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Fusion between transcription factor CBF beta/PEBP2 beta and a myosin heavy chain in acute myeloid leukemia

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Acute myeloid leukemia with Inv (16) produces a chimeric transcription factor with a myosin heavy chain tail

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Human smooth muscle myosin heavy chain gene mapped to chromosomal region 16q12

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The 3;21 translocation in myelodysplasia results in a fusion transcript between the AML1 gene and the gene for EAP, a highly conserved protein associated with the Epstein-Barr virus small RNA EBER 1

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AML1, the target of multiple chromosomal translocations in human leukemia, is essential for normal fetal liver hematopoiesis

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Erythroid differentiation in chimaeric mice blocked by a targeted mutation in the gene for transcription factor GATA-1

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A phorbol ester response element within the human T-cell receptor beta-chain enhancer

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Absence of yolk sac hematopoiesis from mice with a targeted disruption of the scl gene

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Absence of blood formation in mice lacking the T-cell leukaemia oncoprotein tal-1/SCL

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Transactivation of the Moloney murine leukemia virus and T-cell receptor beta-chain enhancers by cbf and ets requires intact binding sites for both proteins

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An early haematopoietic defect in mice lacking the transcription factor GATA-2

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Cloning and characterization of subunits of the T-cell receptor and murine leukemia virus enhancer core-binding factor

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Disruption of the Cbfa2 gene causes necrosis and hemorrhaging in the central nervous system and blocks definitive hematopoiesis

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7 January 2021

The CBFbeta subunit is essential for CBFalpha2 (AML1) function in vivo

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Identification of a region which directs the monocytic activity of the colony-stimulating factor 1 (macrophage colony-stimulating factor) receptor promoter and binds PEBP2/CBF (AML1)

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CCAAT enhancer-binding protein (C/EBP) and AML1 (CBF alpha2) synergistically activate the macrophage colony-stimulating factor receptor promoter

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7 January 2021

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Identifiers

DOI

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16 February 2018

PubMed ID

8929537

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16 February 2018