Hepatic heme-regulated inhibitor (HRI) eukaryotic initiation factor 2alpha kinase: a protagonist of heme-mediated translational control of CYP2B enzymes and a modulator of basal endoplasmic reticulum stress tone (Q33754847)

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English	Hepatic heme-regulated inhibitor (HRI) eukaryotic initiation factor 2alpha kinase: a protagonist of heme-mediated translational control of CYP2B enzymes and a modulator of basal endoplasmic reticulum stress tone	scientific article

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Europe PubMed Central

PubMed publication ID

29 July 2017

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29 December 2023

https://doi.org/10.1124/mol.109.061259retraction

Hepatic heme-regulated inhibitor (HRI) eukaryotic initiation factor 2alpha kinase: a protagonist of heme-mediated translational control of CYP2B enzymes and a modulator of basal endoplasmic reticulum stress tone (English)

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Europe PubMed Central

PubMed publication ID

29 July 2017

endoplasmic reticulum

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Poulomi Acharya

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Poulomi Acharya

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Europe PubMed Central

PubMed publication ID

29 July 2017

Maria Almira Correia

3

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Maria Almira Correia

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Europe PubMed Central

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29 July 2017

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Jane-Jane Chen

2

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Europe PubMed Central

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29 July 2017

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13 January 2010

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Europe PubMed Central

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29 July 2017

Molecular Pharmacology

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Europe PubMed Central

PubMed publication ID

29 July 2017

77

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Europe PubMed Central

PubMed publication ID

29 July 2017

4

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Europe PubMed Central

PubMed publication ID

29 July 2017

575-592

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Europe PubMed Central

PubMed publication ID

29 July 2017

describes a project that uses

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Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC2845940/fullTextXML

based on heuristic

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Hepatic CYP3A suppression by high concentrations of proteasomal inhibitors: a consequence of endoplasmic reticulum (ER) stress induction, activation of RNA-dependent protein kinase-like ER-bound eukaryotic initiation factor 2alpha (eIF2alpha)-kinase

1 reference

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ATF5 is a highly abundant liver-enriched transcription factor that cooperates with constitutive androstane receptor in the transactivation of CYP2B6: implications in hepatic stress responses.

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Impaired dexamethasone-mediated induction of tryptophan 2,3-dioxygenase in heme-deficient rat hepatocytes: translational control by a hepatic eIF2alpha kinase, the heme-regulated inhibitor

1 reference

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Characterization of the physiological turnover of native and inactivated cytochromes P450 3A in cultured rat hepatocytes: a role for the cytosolic AAA ATPase p97?

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Regulation of protein synthesis by the heme-regulated eIF2alpha kinase: relevance to anemias

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Double-stranded RNA-dependent protein kinase phosphorylation of the alpha-subunit of eukaryotic translation initiation factor 2 mediates apoptosis

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Heme-regulated inhibitor kinase-mediated phosphorylation of eukaryotic translation initiation factor 2 inhibits translation, induces stress granule formation, and mediates survival upon arsenite exposure

1 reference

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1 reference

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Autophosphorylation of threonine 485 in the activation loop is essential for attaining eIF2alpha kinase activity of HRI

1 reference

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An integrated stress response regulates amino acid metabolism and resistance to oxidative stress

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The PERK eukaryotic initiation factor 2 alpha kinase is required for the development of the skeletal system, postnatal growth, and the function and viability of the pancreas

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Heme-regulated eIF2alpha kinase (HRI) is required for translational regulation and survival of erythroid precursors in iron deficiency

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Translation initiation control by heme-regulated eukaryotic initiation factor 2alpha kinase in erythroid cells under cytoplasmic stresses

1 reference

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Limited heme synthesis in porphobilinogen deaminase-deficient mice impairs transcriptional activation of specific cytochrome P450 genes by phenobarbital.

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Characterization of the hemin-sensitive eukaryotic initiation factor 2alpha kinase from mouse nonerythroid cells

1 reference

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Erythroid expression of the heme-regulated eIF-2 alpha kinase

1 reference

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Cloning and characterization of cDNA encoding rat hemin-sensitive initiation factor-2 alpha (eIF-2 alpha) kinase. Evidence for multitissue expression

1 reference

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Regulation of heme-regulated eIF-2 alpha kinase and its expression in erythroid cells

1 reference

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Heme may not be a positive regulator of cytochrome-P450 gene expression

1 reference

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1 reference

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Activation of heme-regulated eukaryotic initiation factor 2alpha kinase by nitric oxide is induced by the formation of a five-coordinate NO-heme complex: optical absorption, electron spin resonance, and resonance raman spectral studies

1 reference

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based on heuristic

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Role of heme in phenobarbital induction of cytochromes P450 and 5-aminolevulinate synthase in cultured rat hepatocytes maintained on an extracellular matrix

1 reference

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inferred from PubMed ID database lookup

Tissue distribution and immunoreactivity of heme-regulated eIF-2 alpha kinase determined by monoclonal antibodies

1 reference

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based on heuristic

inferred from PubMed ID database lookup

Heme-regulated eIF-2alpha kinase purifies as a hemoprotein

1 reference

https://pubmed.ncbi.nlm.nih.gov/20071449

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based on heuristic

inferred from PubMed ID database lookup

1 reference

https://pubmed.ncbi.nlm.nih.gov/20071449

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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1 reference

https://pubmed.ncbi.nlm.nih.gov/20071449

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based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1124/MOL.109.061259

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

ResearchGate publication ID

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