Inhibition of mammary carcinoma cell growth by RXR is mediated by the receptor's oligomeric switch. (Q33760867)

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19 January 2020

title

Inhibition of mammary carcinoma cell growth by RXR is mediated by the receptor's oligomeric switch (English)

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19 January 2020

3

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19 January 2020

author name string

Rubina Yasmin

1

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19 January 2020

Padmamalini Kannan-Thulasiraman

2

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19 January 2020

Marcia I Dawson

4

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19 January 2020

Noa Noy

5

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19 January 2020

publication date

24 February 2010

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Journal of Molecular Biology

19 January 2020

published in

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19 January 2020

volume

397

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19 January 2020

page(s)

1121-1131

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19 January 2020

issue

5

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Suppression of mammary carcinoma cell growth by retinoic acid: the cell cycle control gene Btg2 is a direct target for retinoic acid receptor signaling

19 January 2020

cites work

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Loss of B-cell translocation gene-2 in estrogen receptor-positive breast carcinoma is associated with tumor grade and overexpression of cyclin d1 protein

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Suppression of mammary carcinoma growth by retinoic acid: proapoptotic genes are targets for retinoic acid receptor and cellular retinoic acid-binding protein II signaling

14 July 2018

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Retinoid X receptor regulates Nur77/TR3-dependent apoptosis [corrected] by modulating its nuclear export and mitochondrial targeting

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RAR antagonists diminish the level of DNA binding by the RAR/RXR heterodimer

14 July 2018

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Phase 2 and 3 clinical trial of oral bexarotene (Targretin capsules) for the treatment of refractory or persistent early-stage cutaneous T-cell lymphoma.

14 July 2018

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Binding of ligands and activation of transcription by nuclear receptors.

14 July 2018

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Structural basis for autorepression of retinoid X receptor by tetramer formation and the AF-2 helix

14 July 2018

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Retinoid X receptor-antagonistic diazepinylbenzoic acids

14 July 2018

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Identification of a novel class of retinoic acid receptor beta-selective retinoid antagonists and their inhibitory effects on AP-1 activity and retinoic acid-induced apoptosis in human breast cancer cells.

14 July 2018

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Beyond tamoxifen: the retinoid X receptor-selective ligand LGD1069 (TARGRETIN) causes complete regression of mammary carcinoma.

14 July 2018

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The tetramerization region of the retinoid X receptor is important for transcriptional activation by the receptor.

14 July 2018

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The DNA binding pattern of the retinoid X receptor is regulated by ligand-dependent modulation of its oligomeric state

14 July 2018

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Chemoprevention of mammary carcinoma by LGD1069 (Targretin): an RXR-selective ligand

14 July 2018

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Identification of a novel retinoic acid response element in the promoter region of the retinol-binding protein gene

14 July 2018

1 reference

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Conformational effects on retinoid receptor selectivity. 2. Effects of retinoid bridging group on retinoid X receptor activity and selectivity

14 July 2018

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On the role of ligand in retinoid signaling: positive cooperativity in the interactions of 9-cis retinoic acid with tetramers of the retinoid X receptor

14 July 2018

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Retinoid X receptor alpha forms tetramers in solution

14 July 2018

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DNA-looping by RXR tetramers permits transcriptional regulation "at a distance".

14 July 2018

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Retinoic acids exert direct effects on T cells to suppress Th1 development and enhance Th2 development via retinoic acid receptors

30 October 2018

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The retinoid X receptor-selective retinoid, LGD1069, prevents the development of estrogen receptor-negative mammary tumors in transgenic mice.

30 October 2018

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Phase 1 and 2 trial of bexarotene gel for skin-directed treatment of patients with cutaneous T-cell lymphoma

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Induction of adipocyte-specific gene expression is correlated with mammary tumor regression by the retinoid X receptor-ligand LGD1069 (targretin).

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Role of Ligand in Retinoid Signaling. 9-cis-Retinoic Acid Modulates the Oligomeric State of the Retinoid X Receptor

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12 December 2020

Regulation of Retinoidal Actions by Diazepinylbenzoic Acids.1Retinoid Synergists Which Activate the RXR−RAR Heterodimers

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12 December 2020

Auto-silencing by the retinoid X receptor 1 1Edited by M. Yaniv

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12 December 2020

The retinoid X receptor-selective retinoid, LGD1069, down-regulates cyclooxygenase-2 expression in human breast cells through transcription factor crosstalk: implications for molecular-based chemoprevention

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12 December 2020

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Identifiers

DOI

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19 January 2020

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19 January 2020

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