Targeting Nur77 translocation (Q34588195)

3 August 2017

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title

Targeting Nur77 translocation (English)

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3 August 2017

Xiao-kun Zhang

1

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3 August 2017

language of work or name

English

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publication date

1 January 2007

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Expert Opinion on Therapeutic Targets

3 August 2017

published in

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3 August 2017

volume

11

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3 August 2017

issue

1

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3 August 2017

page(s)

69-79

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3 August 2017

cites work

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Apoptosis-based therapies

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Isolation and characterization of human TR3 receptor: a member of steroid receptor superfamily

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A gene inducible by serum growth factors encodes a member of the steroid and thyroid hormone receptor superfamily

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Nerve growth factor induces a gene homologous to the glucocorticoid receptor gene.

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Vitamin A and apoptosis in prostate cancer

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The NR4A subfamily of nuclear receptors: new early genes regulated by growth factors in vascular cells.

21 January 2018

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Nur77 family of nuclear hormone receptors

21 January 2018

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The NR4A subgroup: immediate early response genes with pleiotropic physiological roles

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The RXR heterodimers and orphan receptors

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Nonsteroid nuclear receptors: what are genetic studies telling us about their role in real life?

21 January 2018

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Dual roles of Nur77 in selective regulation of apoptosis and cell cycle by TPA and ATRA in gastric cancer cells

21 January 2018

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Promyelocytic leukemia protein PML inhibits Nur77-mediated transcription through specific functional interactions

21 January 2018

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Orphan nuclear receptor Nur77 translocates to mitochondria in the early phase of apoptosis induced by synthetic chenodeoxycholic acid derivatives in human stomach cancer cell line SNU-1.

21 January 2018

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Prostaglandin E2 regulates the nuclear receptor NR4A2 in colorectal cancer

21 January 2018

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Cancer-specific toxicity of apoptin is independent of death receptors but involves the loss of mitochondrial membrane potential and the release of mitochondrial cell-death mediators by a Nur77-dependent pathway

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.11.1.69

Mitogenic Effect of Orphan Receptor TR3 and Its Regulation by MEKK1 in Lung Cancer Cells

21 January 2018

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Nuclear hormone receptor NR4A2 is involved in cell transformation and apoptosis

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.11.1.69

Hepatitis B virus X protein induced expression of the Nur77 gene.

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.11.1.69

Oncogenic conversion of a novel orphan nuclear receptor by chromosome translocation

21 January 2018

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The EWS/TEC fusion protein encoded by the t(9;22) chromosomal translocation in human chondrosarcomas is a highly potent transcriptional activator

21 January 2018

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Nicotine modulates the effects of retinoids on growth inhibition and RAR beta expression in lung cancer cells

21 January 2018

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Modulation of retinoic acid sensitivity in lung cancer cells through dynamic balance of orphan receptors nur77 and COUP-TF and their heterodimerization

21 January 2018

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Novel function of orphan nuclear receptor Nur77 in stabilizing hypoxia-inducible factor-1alpha

21 January 2018

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Vascular endothelial growth factor-regulated gene expression in endothelial cells: KDR-mediated induction of Egr3 and the related nuclear receptors Nur77, Nurr1, and Nor1.

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.11.1.69

Induction of NR4A orphan nuclear receptor expression in macrophages in response to inflammatory stimuli

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.1.69

Regulation of macrophage inflammatory gene expression by the orphan nuclear receptor Nur77.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.1.69

Inhibition of apoptosis by Nur77 through NF-kappaB activity modulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.1.69

Ceramide-induced cell death is independent of the Fas/Fas ligand pathway and is prevented by Nur77 overexpression in A20 B cells

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.11.1.69

Nur77 as a survival factor in tumor necrosis factor signaling

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.11.1.69

Apoptotic signals delivered through the T-cell receptor of a T-cell hybrid require the immediate-early gene nur77.

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.11.1.69

Requirement for the orphan steroid receptor Nur77 in apoptosis of T-cell hybridomas

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.11.1.69

Synthetic retinoids as inducers of apoptosis in ovarian carcinoma cell lines

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.11.1.69

Retinoid targets for apoptosis induction

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.11.1.69

Classical and novel retinoids: their targets in cancer therapy

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.11.1.69

Mitochondrion as a novel target of anticancer chemotherapy

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.11.1.69

Early events in the induction of apoptosis in ovarian carcinoma cells by CD437: activation of the p38 MAP kinase signal pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.1.69

Cytochrome c release and apoptosis induced by mitochondrial targeting of nuclear orphan receptor TR3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.1.69

Retinoid X receptor regulates Nur77/TR3-dependent apoptosis [corrected] by modulating its nuclear export and mitochondrial targeting

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.1.69

Conversion of Bcl-2 from protector to killer by interaction with nuclear orphan receptor Nur77/TR3

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.1.69

Identification by DNA macroarray of nur77 as a gene induced by di-n-butyltin dichloride: its role in organotin-induced apoptosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.1.69

Enhancing the antitumor activity of ErbB blockade with histone deacetylase (HDAC) inhibition.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.1.69

Induction of orphan nuclear receptor Nur77 gene expression and its role in cadmium-induced apoptosis in lung

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.1.69

Activation of Nur77 by selected 1,1-Bis(3'-indolyl)-1-(p-substituted phenyl)methanes induces apoptosis through nuclear pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.1.69

Diffuse large B-cell lymphoma outcome prediction by gene-expression profiling and supervised machine learning

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.1.69

A molecular signature of metastasis in primary solid tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.1.69

Comparison of the mechanism of induction of apoptosis in ovarian carcinoma cells by the conformationally restricted synthetic retinoids CD437 and 4‐HPR

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.1.69

Rapid apoptosis induction by IGFBP-3 involves an insulin-like growth factor-independent nucleomitochondrial translocation of RXRalpha/Nur77.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.1.69

Epstein-Barr virus EBNA2 blocks Nur77- mediated apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.1.69

EBNA2 is required for protection of latently Epstein-Barr virus-infected B cells against specific apoptotic stimuli.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.1.69

ERK2 prohibits apoptosis-induced subcellular translocation of orphan nuclear receptor NGFI-B/TR3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.1.69

Conversion of Bcl-2 to a Bax-like death effector by caspases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.1.69

Alphaviruses induce apoptosis in Bcl-2-overexpressing cells: evidence for a caspase-mediated, proteolytic inactivation of Bcl-2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.1.69

Pro-apoptotic activity of transiently expressed BCL-2 occurs independent of BAX and BAK.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.1.69

A potent cell death activity associated with transient high level expression of BCL-2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.1.69

Caenorhabditis elegans CED-9 protein is a bifunctional cell-death inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.1.69

Drob-1, a Drosophila member of the Bcl-2/CED-9 family that promotes cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.1.69

Clinical studies of Bcl-2 and treatment benefit in breast cancer patients.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.1.69

BCL-2 in prostate cancer: a minireview

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.1.69

Role of Bcl-2 as a prognostic factor for survival in lung cancer: a systematic review of the literature with meta-analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.1.69

Prognostic and predictive effects of immunohistochemical factors in high-risk primary breast cancer patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.1.69

Evidence that the p53 negative / Bcl-2 positive phenotype is an independent indicator of good prognosis in colorectal cancer: a tissue microarray study of 460 patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.1.69

Expression of phosphorylated Ser70 of Bcl-2 correlates with malignancy in human colorectal neoplasms

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.1.69

Expression of Bcl-2 in gastrointestinal stromal tumors: correlation with progression-free survival in 81 patients treated with imatinib mesylate

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.1.69

The Bcl-2 family: roles in cell survival and oncogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.1.69

21 January 2018

Bcl-2 family proteins

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.1.69

Deletion of the loop region of Bcl-2 completely blocks paclitaxel-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.1.69

Inactivation of Bcl-2 by phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.1.69

Bcl-xL deamidation is a critical switch in the regulation of the response to DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.1.69

Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.1.69

Treatment of melanoma cells with the synthetic retinoid CD437 induces apoptosis via activation of AP-1 in vitro, and causes growth inhibition in xenografts in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.1.69

In acute promyelocytic leukemia NB4 cells, the synthetic retinoid CD437 induces contemporaneously apoptosis, a caspase-3-mediated degradation of PML/RARalpha protein and the PML retargeting on PML-nuclear bodies

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.1.69

Activity of retinoic acid receptor-gamma selectively binding retinoids alone and in combination with interferon-gamma in breast cancer cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.1.69

Regulation of Nur77 nuclear export by c-Jun N-terminal kinase and Akt.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.1.69

Crosstalk between ERK2 and RXR regulates nuclear import of transcription factor NGFI-B.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.1.69

Nuclear receptor and apoptosis initiator NGFI-B is a substrate for kinase ERK2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.1.69

Akt inhibits the orphan nuclear receptor Nur77 and T-cell apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.1.69

Akt phosphorylates and regulates the orphan nuclear receptor Nur77

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.1.69

Transcription factor phosphorylation by pp90(rsk2). Identification of Fos kinase and NGFI-B kinase I as pp90(rsk2).

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.1.69

RXRalpha acts as a carrier for TR3 nuclear export in a 9-cis retinoic acid-dependent manner in gastric cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.1.69

Retinoic acid inhibition of ex vivo human immunodeficiency virus-associated apoptosis of peripheral blood cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.1.69

DNA-binding mechanism of the monomeric orphan nuclear receptor NGFI-B

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.1.69

The R-enantiomer of the nonsteroidal antiinflammatory drug etodolac binds retinoid X receptor and induces tumor-selective apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.1.69

Docosahexaenoic acid, a ligand for the retinoid X receptor in mouse brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.1.69

Functional redundancy of the Nur77 and Nor-1 orphan steroid receptors in T-cell apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.1.69

A role for the orphan steroid receptor Nur77 in apoptosis accompanying antigen-induced negative selection

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.1.69

Inhibition of Nur77/Nurr1 leads to inefficient clonal deletion of self-reactive T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.1.69

Cancer-selective therapy of the future: apoptin and its mechanism of action

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.1.69

Crystal structure of a heterodimeric complex of RAR and RXR ligand-binding domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.1.69

Crystal structure of the human RXRalpha ligand-binding domain bound to its natural ligand: 9-cis retinoic acid

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.1.69

The Drosophila orphan nuclear receptor DHR38 mediates an atypical ecdysteroid signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.1.69

Structure and function of Nurr1 identifies a class of ligand-independent nuclear receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.1.69

Prostaglandin A2 acts as a transactivator for NOR1 (NR4A3) within the nuclear receptor superfamily

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.1.69

BCL-2 is phosphorylated and inactivated by an ASK1/Jun N-terminal protein kinase pathway normally activated at G(2)/M.

21 January 2018

1 reference

24 May 2022

https://opencitations.net/index/coci/api/v1/citations/10.1128/MCB.19.12.8469

Identifiers

DOI

10.1517/14728222.11.1.69

1 reference

3 August 2017

1 reference