Gene therapy targeting glaucoma: where are we? (Q33763673)

29 July 2017

1 reference

title

Gene therapy targeting glaucoma: where are we? (English)

1 reference

29 July 2017

0 references

Xuyang Liu

1

1 reference

29 July 2017

Carol A Rasmussen

2

1 reference

29 July 2017

B'ann T Gabelt

3

1 reference

29 July 2017

Curtis R Brandt

4

1 reference

29 July 2017

Paul L Kaufman

5

1 reference

29 July 2017

publication date

1 July 2009

1 reference

29 July 2017

published in

Survey of Ophthalmology

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29 July 2017

volume

54

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29 July 2017

issue

4

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29 July 2017

page(s)

472-486

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Effect of gene therapy on visual function in Leber's congenital amaurosis

29 July 2017

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22 June 2018

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Characterization of retinal damage in the episcleral vein cauterization rat glaucoma model

22 June 2018

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Changes in aqueous humor dynamics with age and glaucoma

22 June 2018

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p21WAF-1/Cip-1 gene therapy as an adjunct to glaucoma filtration surgery

22 June 2018

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22 June 2018

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22 June 2018

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Gene therapy for optic nerve disease

22 June 2018

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22 June 2018

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22 June 2018

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22 June 2018

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22 June 2018

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22 June 2018

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22 June 2018

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22 June 2018

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22 June 2018

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22 June 2018

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22 June 2018

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22 June 2018

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22 June 2018

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22 June 2018

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22 June 2018

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22 June 2018

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22 June 2018

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22 June 2018

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22 June 2018

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22 June 2018

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22 June 2018

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22 June 2018

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22 June 2018

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22 June 2018

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22 June 2018

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22 June 2018

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22 June 2018

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22 June 2018

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30 October 2018

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Protein kinase C-zeta mediates retinal degeneration in response to TNF.

30 October 2018

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A rat model of glaucoma induced by episcleral vein ligation.

30 October 2018

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Microarray analysis of retinal gene expression in the DBA/2J model of glaucoma

30 October 2018

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Analysis of expression of matrix metalloproteinases and tissue inhibitors of metalloproteinases in human ciliary body after latanoprost

30 October 2018

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Caldesmon transgene expression disrupts focal adhesions in HTM cells and increases outflow facility in organ-cultured human and monkey anterior segments.

30 October 2018

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The effect of C3 transgene expression on actin and cellular adhesions in cultured human trabecular meshwork cells and on outflow facility in organ cultured monkey eyes.

30 October 2018

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XIAP-mediated neuroprotection in retinal ischemia

30 October 2018

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Effect of bimatoprost on intraocular pressure in prostaglandin FP receptor knockout mice

30 October 2018

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30 October 2018

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Blebbistatin, a novel inhibitor of myosin II ATPase activity, increases aqueous humor outflow facility in perfused enucleated porcine eyes.

30 October 2018

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Gene therapy restores vision-dependent behavior as well as retinal structure and function in a mouse model of RPE65 Leber congenital amaurosis

30 October 2018

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30 October 2018

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Effects of cholesterol-lowering statins on the aqueous humor outflow pathway

30 October 2018

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Activation of the extracellular signal-regulated kinase 1/2 pathway by AAV gene transfer protects retinal ganglion cells in glaucoma

30 October 2018

1 reference

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Expression of dominant negative Rho-binding domain of Rho-kinase in organ cultured human eye anterior segments increases aqueous humor outflow.

30 October 2018

1 reference

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Extracellular signal-regulated kinase 1/2 mediates survival, but not axon regeneration, of adult injured central nervous system neurons in vivo

30 October 2018

1 reference

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Long-term in vivo inhibition of CNS neurodegeneration by Bcl-XL gene transfer

30 October 2018

1 reference

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Effects of the Rho kinase inhibitor Y-27632 and the phosphatase inhibitor calyculin A on outflow facility in monkeys

30 October 2018

1 reference

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Regulation of myosin light chain phosphorylation in the trabecular meshwork: role in aqueous humour outflow facility

30 October 2018

1 reference

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Myocilin binding to Hep II domain of fibronectin inhibits cell spreading and incorporation of paxillin into focal adhesions

30 October 2018

1 reference

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Effect of different dose schedules of 0.15% unoprostone isopropyl on intraocular pressure and pupil size in the glaucomatous beagle

30 October 2018

1 reference

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Long-term, targeted genetic modification of the aqueous humor outflow tract coupled with noninvasive imaging of gene expression in vivo

30 October 2018

1 reference

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Ganglion cell death in rat retina by persistent intraocular pressure elevation

30 October 2018

1 reference

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Alpha-fodrin is cleaved by caspase-3 in a chronic ocular hypertensive (COH) rat model of glaucoma

30 October 2018

1 reference

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Gene therapy using p21WAF-1/Cip-1 to modulate wound healing after glaucoma trabeculectomy surgery in a primate model of ocular hypertension

30 October 2018

1 reference

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Role of tumor necrosis factor receptor-1 in the death of retinal ganglion cells following optic nerve crush injury in mice

30 October 2018

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Effect of heparin II domain of fibronectin on aqueous outflow in cultured anterior segments of human eyes.

30 October 2018

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Organ-specific gene expression in the rhesus monkey eye following intravenous non-viral gene transfer

30 October 2018

1 reference

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Characterization of adenovirus p21 gene transfer, biodistribution, and immune response after local ocular delivery in New Zealand white rabbits

30 October 2018

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Sustained tetracycline-regulated transgene expression in vivo in rat retinal ganglion cells using a single type 2 adeno-associated viral vector

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2848072

Intraocular gene delivery of ciliary neurotrophic factor results in significant loss of retinal function in normal mice and in the Prph2Rd2/Rd2 model of retinal degeneration

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2848072

The role of protein kinase C in modulation of aqueous humor outflow facility

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2848072

Preservation of aqueous outflow facility after second-generation FIV vector-mediated expression of marker genes in anterior segments of human eyes

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2848072

Effects of adeno-associated virus-vectored ciliary neurotrophic factor on retinal structure and function in mice with a P216L rds/peripherin mutation

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2848072

Adenovirus-mediated gene therapy using human p21WAF-1/Cip-1 to prevent wound healing in a rabbit model of glaucoma filtration surgery

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2848072

The Ocular Hypertension Treatment Study: a randomized trial determines that topical ocular hypotensive medication delays or prevents the onset of primary open-angle glaucoma.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2848072

Baculoviral IAP repeat-containing-4 protects optic nerve axons in a rat glaucoma model

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2848072

Gene transfer of dominant-negative RhoA increases outflow facility in perfused human anterior segment cultures.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2848072

Exchange of surface proteins impacts on viral vector cellular specificity and transduction characteristics: the retina as a model

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2848072

Stromelysin gene transfer into cultured human trabecular cells and rat trabecular meshwork in vivo

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2848072

Non-invasive observation of repeated adenoviral GFP gene delivery to the anterior segment of the monkey eye in vivo.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2848072

Adenovirus-mediated gene transfer in canine eyes: a preclinical study for gene therapy of human uveal melanoma

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2848072

TNF-alpha and TNF-alpha receptor-1 in the retina of normal and glaucomatous eyes

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2848072

Modulation of aqueous humor outflow facility by the Rho kinase-specific inhibitor Y-27632.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2848072

ML-7, chelerythrine and phorbol ester increase outflow facility in the monkey Eye.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2848072

Recombinant TIGR/MYOC increases outflow resistance in the human anterior segment.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2848072

Enhanced short-term plasmid transfection of filtration surgery tissues.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2848072

Herpes simplex virus mediated gene transfer to primate ocular tissues

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2848072

Reporter expression persists 1 year after adeno-associated virus-mediated gene transfer to the optic nerve

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2848072

Persistent transgene product in retina, optic nerve and brain after intraocular injection of rAAV.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2848072

H-7 disrupts the actin cytoskeleton and increases outflow facility.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2848072

Introduction of DNA into the rat and primate trabecular meshwork by fusogenic liposomes.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2848072

A rat model for acute rise in intraocular pressure: immune modulation as a therapeutic strategy

30 October 2018

1 reference

12 December 2020

Comparison of the effect of hypertonic hydroxyethyl starch and mannitol on the intraocular pressure in healthy normotensive dogs and the effect of hypertonic hydroxyethyl starch on the intraocular pressure in dogs with primary glaucoma

1 reference

12 December 2020

Experimental induction of retinal ganglion cell death in adult mice

1 reference

12 December 2020

Aqueous humor dynamics in the aging human eye

1 reference

12 December 2020

Heparin II Domain of Fibronectin Uses α4β1 Integrin to Control Focal Adhesion and Stress Fiber Formation, Independent of Syndecan-4

1 reference

12 December 2020

The Advanced Glaucoma Intervention Study (AGIS): 7. The relationship between control of intraocular pressure and visual field deterioration.The AGIS Investigators

1 reference

12 December 2020

A new model of glaucoma filtering surgery in the rat

1 reference

12 December 2020

Ultrahistochemical studies on tangential sections of the trabecular meshwork in normal and glaucomatous eyes

1 reference

12 December 2020

Adrenergic regulation of aqueous outflow

1 reference

12 December 2020

Overexpression of BCL-2 in transgenic mice protects neurons from naturally occurring cell death and experimental ischemia

1 reference

12 December 2020

In vivo gene transfer into murine corneal endothelial and trabecular meshwork cells

1 reference

12 December 2020

Manometric calibration and comparison of TonoLab and TonoPen tonometers in rats with experimental glaucoma and in normal mice

1 reference

12 December 2020

Trabeculectomy with mitomycin C

1 reference

12 December 2020

Latrunculin-A increases outflow facility in the monkey

1 reference

12 December 2020

Aqueous humor dynamics in ocular hypertensive patients

1 reference

12 December 2020

10.1016/J.SURVOPHTHAL.2009.04.003

Identifiers

DOI

1 reference

29 July 2017

1 reference

29 July 2017

1 reference