Strategies for silencing human disease using RNA interference (Q28288535)

describes a project that uses

Europe PubMed Central

title

Strategies for silencing human disease using RNA interference (English)

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Daniel H Kim

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John J Rossi

series ordinal

2

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language of work or name

English

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publication date

March 2007

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published in

Nature Reviews Genetics

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volume

8

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page(s)

173-84

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issue

3

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Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans

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Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells

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Unlocking the potential of the human genome with RNA interference

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Gene therapy for proliferative ocular diseases

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Inhibition of respiratory viruses by nasally administered siRNA.

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RNAi as a treatment for HIV-1 infection.

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Silencing Viral Infection

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Viral-based modelling and correction of neurodegenerative diseases by RNA interference.

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Prospects of RNA interference therapy for cancer

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Approaches for chemically synthesized siRNA and vector-mediated RNAi

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Detection of foreign RNA: implications for RNAi

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Fatality in mice due to oversaturation of cellular microRNA/short hairpin RNA pathways

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Progress towards in vivo use of siRNAs

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Mechanisms of gene silencing by double-stranded RNA

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RNAi-mediated pathways in the nucleus

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The role of the RNAi machinery in heterochromatin formation

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RNAi: double-stranded RNA directs the ATP-dependent cleavage of mRNA at 21 to 23 nucleotide intervals

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Role for a bidentate ribonuclease in the initiation step of RNA interference

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Single-stranded antisense siRNAs guide target RNA cleavage in RNAi

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Argonaute2 is the catalytic engine of mammalian RNAi

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Passenger-strand cleavage facilitates assembly of siRNA into Ago2-containing RNAi enzyme complexes

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Argonaute2 cleaves the anti-guide strand of siRNA during RISC activation

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Structural insights into mRNA recognition from a PIWI domain-siRNA guide complex

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Structural basis for overhang-specific small interfering RNA recognition by the PAZ domain

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RNA interference is mediated by 21- and 22-nucleotide RNAs

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Decay of mRNAs targeted by RISC requires XRN1, the Ski complex, and the exosome

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A microRNA in a multiple-turnover RNAi enzyme complex

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Micromanagers of gene expression: the potentially widespread influence of metazoan microRNAs

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The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14

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Posttranscriptional regulation of the heterochronic gene lin-14 by lin-4 mediates temporal pattern formation in C. elegans

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MicroRNA-dependent localization of targeted mRNAs to mammalian P-bodies

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MicroRNA-directed cleavage of HOXB8 mRNA

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MicroRNA genes are transcribed by RNA polymerase II

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RNA polymerase III transcribes human microRNAs

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The nuclear RNase III Drosha initiates microRNA processing

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The Microprocessor complex mediates the genesis of microRNAs

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Exportin-5 mediates the nuclear export of pre-microRNAs and short hairpin RNAs

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Nuclear export of microRNA precursors

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TRBP recruits the Dicer complex to Ago2 for microRNA processing and gene silencing

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The role of PACT in the RNA silencing pathway

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RNAi: RISC gets loaded.

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Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets

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Second-generation shRNA libraries covering the mouse and human genomes

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Small interfering RNA-induced transcriptional gene silencing in human cells

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Argonaute-1 directs siRNA-mediated transcriptional gene silencing in human cells

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Involvement of AGO1 and AGO2 in mammalian transcriptional silencing

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Short double-stranded RNA induces transcriptional gene silencing in human cancer cells in the absence of DNA methylation

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The antisense strand of small interfering RNAs directs histone methylation and transcriptional gene silencing in human cells

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Gene expression: long-term gene silencing by RNAi

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Synthetic dsRNA Dicer substrates enhance RNAi potency and efficacy.

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Synthetic shRNAs as potent RNAi triggers.

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A structural basis for discriminating between self and nonself double-stranded RNAs in mammalian cells.

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A system for stable expression of short interfering RNAs in mammalian cells

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Short hairpin RNAs (shRNAs) induce sequence-specific silencing in mammalian cells

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Both natural and designed micro RNAs can inhibit the expression of cognate mRNAs when expressed in human cells

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MicroRNAs: expression, avoidance and subversion by vertebrate viruses

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Widespread siRNA "off-target" transcript silencing mediated by seed region sequence complementarity

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3' UTR seed matches, but not overall identity, are associated with RNAi off-targets

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Sequence-specific potent induction of IFN-alpha by short interfering RNA in plasmacytoid dendritic cells through TLR7

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Interactions between double-stranded RNA regulators and the protein kinase DAI

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Antiviral innate immunity pathways.

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Sequence-dependent stimulation of the mammalian innate immune response by synthetic siRNA

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Interferon induction by siRNAs and ssRNAs synthesized by phage polymerase

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Stable expression of shRNAs in human CD34+ progenitor cells can avoid induction of interferon responses to siRNAs in vitro

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Optimization and functional effects of stable short hairpin RNA expression in primary human lymphocytes via lentiviral vectors.

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Structural variations and stabilising modifications of synthetic siRNAs in mammalian cells

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Activity of stabilized short interfering RNA in a mouse model of hepatitis B virus replication

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siRNA function in RNAi: a chemical modification analysis

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Potent and persistent in vivo anti-HBV activity of chemically modified siRNAs

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Therapeutic silencing of an endogenous gene by systemic administration of modified siRNAs

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RNAi-mediated gene silencing in non-human primates.

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Antibody mediated in vivo delivery of small interfering RNAs via cell-surface receptors

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Cell type-specific delivery of siRNAs with aptamer-siRNA chimeras

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Aptamer mediated siRNA delivery

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Sequence-specific knockdown of EWS-FLI1 by targeted, nonviral delivery of small interfering RNA inhibits tumor growth in a murine model of metastatic Ewing's sarcoma

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Lentiviral-mediated delivery of siRNAs for antiviral therapy

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Therapeutic short hairpin RNA expression in the liver: viral targets and vectors

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Expression of small interfering RNAs targeted against HIV-1 rev transcripts in human cells

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siRNA-directed inhibition of HIV-1 infection

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Modulation of HIV-1 replication by RNA interference

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Potent and specific inhibition of human immunodeficiency virus type 1 replication by RNA interference

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RISC is a 5' phosphomonoester-producing RNA endonuclease

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The role of a mutant CCR5 allele in HIV-1 transmission and disease progression.

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Long-term inhibition of HIV-1 infection in primary hematopoietic cells by lentiviral vector delivery of a triple combination of anti-HIV shRNA, anti-CCR5 ribozyme, and a nucleolar-localizing TAR decoy

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Inhibition of respiratory syncytial virus infection with intranasal siRNA nanoparticles targeting the viral NS1 gene

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An siRNA-based microbicide protects mice from lethal herpes simplex virus 2 infection

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RNAi suppresses polyglutamine-induced neurodegeneration in a model of spinocerebellar ataxia.

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Lentiviral-mediated silencing of SOD1 through RNA interference retards disease onset and progression in a mouse model of ALS.

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Silencing mutant SOD1 using RNAi protects against neurodegeneration and extends survival in an ALS model

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Therapeutic EphA2 gene targeting in vivo using neutral liposomal small interfering RNA delivery

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Knocking down disease with siRNAs

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31 March 2020

Identifiers

DOI

10.1038/NRG2006

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Consolidated OpenCitations Corpus – April 2017

Dimensions Publication ID

1759198

1029198606

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Fatcat ID

release_7h3jpllm3ff4hnvk6vqwi4czre

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1759198

1 reference

Consolidated OpenCitations Corpus – April 2017

Consolidated OpenCitations Corpus – April 2017

1 reference