Therapeutic targets for hypoxia-elicited pathways (Q33770277)

29 July 2017

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title

Therapeutic targets for hypoxia-elicited pathways (English)

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29 July 2017

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C T Taylor

1

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PubMed ID

10554089

29 July 2017

S P Colgan

series ordinal

2

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29 July 2017

1 October 1999

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29 July 2017

Pharmaceutical Research

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29 July 2017

16

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29 July 2017

10

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29 July 2017

1498-1505

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Host tissue damage by phagocytes

29 July 2017

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12 December 2020

Oxygen sensing and molecular adaptation to hypoxia

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12 December 2020

Angiostatin induces and sustains dormancy of human primary tumors in mice

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12 December 2020

Lipoxin B4 regulates human monocyte/neutrophil adherence and motility: design of stable lipoxin B4 analogs with increased biologic activity.

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12 December 2020

Sulfasalazine: a potent and specific inhibitor of nuclear factor kappa B

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12 December 2020

Hypoxic induction of interleukin-8 gene expression in human endothelial cells

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12 December 2020

The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

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12 December 2020

The nitric oxide/cyclic GMP pathway in organ transplantation: critical role in successful lung preservation

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12 December 2020

Inhibition of hypoxia-inducible factor 1 activity by nitric oxide donors in hypoxia

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12 December 2020

Gene therapy for vascular disease

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12 December 2020

Response of purine metabolism to hypoxia and ischemia

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12 December 2020

Hypoxia response elements

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12 December 2020

Role of nitric oxide in tumour progression: lessons from human tumours

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12 December 2020

Hypoxia induces cyclooxygenase-2 via the NF-kappaB p65 transcription factor in human vascular endothelial cells

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12 December 2020

Design of lipoxin A4 stable analogs that block transmigration and adhesion of human neutrophils.

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12 December 2020

Regulation of the hypoxia-inducible transcription factor 1alpha by the ubiquitin-proteasome pathway

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12 December 2020

Inhibition of NF-kappa B by sodium salicylate and aspirin

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12 December 2020

Pathophysiology of ischaemia reperfusion injury: central role of the neutrophil

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12 December 2020

Endothelial cell tolerance to hypoxia. Potential role of purine nucleotide phosphates.

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12 December 2020

Regulated expression of a foreign gene targeted to the ischaemic myocardium

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12 December 2020

Purification and characterization of hypoxia-inducible factor 1

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12 December 2020

Specific inhibition of iNOS decreases the intestinal mucosal peroxynitrite level and improves the barrier function after thermal injury

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12 December 2020

Oxygen sensing, hypoxia-inducible factor-1 and the regulation of mammalian gene expression.

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12 December 2020

Activated endothelial cells elicit paracrine induction of epithelial chloride secretion. 6-Keto-PGF1alpha is an epithelial secretagogue

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12 December 2020

Thalidomide is an inhibitor of angiogenesis

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12 December 2020

Cardioprotection due to preconditioning correlates with increased ecto-5'-nucleotidase activity

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12 December 2020

Epithelial exposure to hypoxia modulates neutrophil transepithelial migration

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12 December 2020

Effect of hypoxia on adherence of granulocytes to endothelial cells in vitro

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12 December 2020

Anti-tumor and anti-metastatic effects of human-vascular-endothelial-growth-factor-neutralizing antibody on human colon and gastric carcinoma xenotransplanted orthotopically into nude mice

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12 December 2020

Hypoxia-mediated induction of endothelial cell interleukin-1 alpha. An autocrine mechanism promoting expression of leukocyte adhesion molecules on the vessel surface

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12 December 2020

Regulated delivery of therapeutic proteins after in vivo somatic cell gene transfer.

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12 December 2020

p53 inhibits hypoxia-inducible factor-stimulated transcription

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12 December 2020

Carbon monoxide and nitric oxide suppress the hypoxic induction of vascular endothelial growth factor gene via the 5' enhancer.

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12 December 2020

Pathogen-induced chemokine secretion from model intestinal epithelium is inhibited by lipoxin A4 analogs

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12 December 2020

A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation

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12 December 2020

Hypoxia enhances induction of endothelial ICAM-1: role for metabolic acidosis and proteasomes.

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12 December 2020

Adenosine, an endogenous anti-inflammatory agent

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12 December 2020

Regulation of erythropoietin production. New insights into molecular mechanisms of oxygen homeostasis.

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12 December 2020

Cardioprotection by ischemic preconditioning. Role of adenosine and glycogen

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12 December 2020

Differential regulation and function of CD73, a glycosyl-phosphatidylinositol-linked 70-kD adhesion molecule, on lymphocytes and endothelial cells

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12 December 2020

Sepsis is associated with increased mRNAs of the ubiquitin-proteasome proteolytic pathway in human skeletal muscle

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12 December 2020

Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1

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12 December 2020

Adenovirus-mediated regulable target gene expression in vivo

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12 December 2020

Neutrophil-mediated changes in vascular permeability are inhibited by topical application of aspirin-triggered 15-epi-lipoxin A4 and novel lipoxin B4 stable analogues

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12 December 2020

Vascular endothelial growth factor

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12 December 2020

Nuclear factor-kappaB: a pivotal transcription factor in chronic inflammatory diseases

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12 December 2020

Tumor oxygenation: a matter of supply and demand.

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12 December 2020

Endostatin: an endogenous inhibitor of angiogenesis and tumor growth

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12 December 2020

Actions of lipoxin A4 and related compounds in smooth muscle preparations and on the microcirculation in vivo

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12 December 2020

Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension

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12 December 2020

Lipoxin A4 modulates transmigration of human neutrophils across intestinal epithelial monolayers

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12 December 2020

Erythropoietin: a model system for studying oxygen-dependent gene regulation.

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12 December 2020

Restoration of the cAMP second messenger pathway enhances cardiac preservation for transplantation in a heterotopic rat model

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12 December 2020

Epithelial permeability induced by neutrophil transmigration is potentiated by hypoxia: role of intracellular cAMP.

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12 December 2020

Critical role of cAMP response element binding protein expression in hypoxia-elicited induction of epithelial tumor necrosis factor-alpha.

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12 December 2020

The ubiquitin-mediated proteolytic pathway as a therapeutic area

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12 December 2020

Lactacystin, proteasome function, and cell fate

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12 December 2020

Modulation of endothelial function by hypoxia: perturbation of barrier and anticoagulant function, and induction of a novel factor X activator

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12 December 2020

Mechanisms of cell death in hypoxia/reoxygenation injury

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12 December 2020

Oxygen transport in tumors: characteristics and clinical implications

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12 December 2020

Hypoxia-inducible factor-1 modulates gene expression in solid tumors and influences both angiogenesis and tumor growth.

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12 December 2020

Hypoxia inhibits cyclic nucleotide-stimulated epithelial ion transport: role for nucleotide cyclases as oxygen sensors

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12 December 2020

Proteasome inhibitors: valuable new tools for cell biologists

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12 December 2020

Linkage of aerobic glycolysis to sodium-potassium transport in rat skeletal muscle. Implications for increased muscle lactate production in sepsis

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12 December 2020

Vascular endothelial growth factor is a potential tumour angiogenesis factor in human gliomas in vivo.

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12 December 2020

General involvement of hypoxia-inducible factor 1 in transcriptional response to hypoxia

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12 December 2020

Macrovascular and microvascular endothelium during long-term hypoxia: alterations in cell growth, monolayer permeability, and cell surface coagulant properties

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12 December 2020

Novel preservation solution permits 24-hour preservation in rat and baboon cardiac transplant models

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12 December 2020

Lipid mediator networks in cell signaling: update and impact of cytokines.

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12 December 2020

Vascular endothelial growth factor: gene therapy and therapeutic angiogenesis

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12 December 2020

Inducible operation of the erythropoietin 3' enhancer in multiple cell lines: evidence for a widespread oxygen-sensing mechanism

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12 December 2020

Molecular events in neutrophil transepithelial migration

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12 December 2020

Cyclic AMP-dependent pathway that mediates suppressive regulation of glycosaminoglycan production in cultured vascular endothelial cells

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12 December 2020

CREB-binding protein is a nuclear integrator of nuclear factor-kappaB and p53 signaling

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12 December 2020

Selective pharmacological inhibition of distinct nitric oxide synthase isoforms

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12 December 2020

Selection of novel analogs of thalidomide with enhanced tumor necrosis factor alpha inhibitory activity

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12 December 2020

Hypoxia-induced increased permeability of endothelial monolayers occurs through lowering of cellular cAMP levels

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12 December 2020

Transcriptional regulation by cyclic AMP.

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12 December 2020

Characterization of the genomic structure, chromosomal location and promoter of human prostaglandin H synthase-2 gene

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12 December 2020

The hypoxic response: huffing and HIFing

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12 December 2020

Aspirin-triggered lipoxins (15-epi-LX) are generated by the human lung adenocarcinoma cell line (A549)-neutrophil interactions and are potent inhibitors of cell proliferation.

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12 December 2020

Adhesion receptors of the immune system

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12 December 2020

Tumor Vasculature Targeted Therapies

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12 December 2020

Autocrine regulation of epithelial permeability by hypoxia: role for polarized release of tumor necrosis factor alpha.

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12 December 2020

Regulation of hypoxia-inducible factor 1alpha is mediated by an O2-dependent degradation domain via the ubiquitin-proteasome pathway

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12 December 2020

The hypoxia-inducible factor-1 DNA recognition site is cAMP-responsive

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12 December 2020

Preconditioning of bovine endothelial cells. The protective effect is mediated by an adenosine A2 receptor through a protein kinase C signaling pathway

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12 December 2020

Transcriptional regulation of endothelial cell adhesion molecules: NF-kappa B and cytokine-inducible enhancers.

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12 December 2020

Hypoxia-inducible factor 1: master regulator of O2 homeostasis

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12 December 2020

Lipoxin biosynthesis and its impact in inflammatory and vascular events

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12 December 2020

Role of HIF-1alpha in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis

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12 December 2020

Aspirin triggers previously undescribed bioactive eicosanoids by human endothelial cell-leukocyte interactions

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12 December 2020

Hypoxia enhances stimulus-dependent induction of E-selectin on aortic endothelial cells.

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12 December 2020

Identifiers

DOI

10.1023/A:1011936016833

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29 July 2017

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PubMed ID

10554089