Inhibition of stearoyl-CoA desaturase 1 expression induces CHOP-dependent cell death in human cancer cells (Q33778696)

29 July 2017

Inhibition of stearoyl-CoA desaturase 1 expression induces CHOP-dependent cell death in human cancer cells (English)

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29 July 2017

1 reference

Mélaine Minville-Walz

1

1 reference

29 July 2017

Anne-Sophie Pierre

2

1 reference

29 July 2017

Laurent Pichon

3

1 reference

29 July 2017

Sandrine Bellenger

4

1 reference

29 July 2017

Cécile Fèvre

5

1 reference

29 July 2017

Jérôme Bellenger

6

1 reference

29 July 2017

Christian Tessier

7

1 reference

29 July 2017

Michel Narce

8

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29 July 2017

Mickaël Rialland

9

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29 July 2017

language of work or name

English

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publication date

16 December 2010

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29 July 2017

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29 July 2017

5

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29 July 2017

e14363

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29 July 2017

12

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Creative Commons Attribution 4.0 International

29 July 2017

start time

16 December 2010

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April 2022 Public Data File from Crossref

copyright status

copyrighted

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cites work

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Abrogation of de novo lipogenesis by stearoyl-CoA desaturase 1 inhibition interferes with oncogenic signaling and blocks prostate cancer progression in mice

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Novel, potent, selective, and metabolically stable stearoyl-CoA desaturase (SCD) inhibitors

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Inhibition of Stearoyl-CoA Desaturase 1 expression in human lung adenocarcinoma cells impairs tumorigenesis.

4 July 2018

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4 July 2018

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Apoptosis induced by t10,c12-conjugated linoleic acid is mediated by an atypical endoplasmic reticulum stress response

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The unfolded protein response regulator GRP78/BiP as a novel target for increasing chemosensitivity in malignant gliomas.

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Inhibition of MEK sensitizes human melanoma cells to endoplasmic reticulum stress-induced apoptosis

4 July 2018

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ER stress triggers apoptosis by activating BH3-only protein Bim

4 July 2018

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Signal integration in the endoplasmic reticulum unfolded protein response

4 July 2018

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Identification of Ras-related nuclear protein, targeting protein for xenopus kinesin-like protein 2, and stearoyl-CoA desaturase 1 as promising cancer targets from an RNAi-based screen.

4 July 2018

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Saturated fatty acid-mediated endoplasmic reticulum stress and apoptosis are augmented by trans-10, cis-12-conjugated linoleic acid in liver cells

4 July 2018

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Transient receptor potential vanilloid 1 agonists cause endoplasmic reticulum stress and cell death in human lung cells

4 July 2018

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Chronic palmitate but not oleate exposure induces endoplasmic reticulum stress, which may contribute to INS-1 pancreatic beta-cell apoptosis

4 July 2018

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Characterization of HSCD5, a novel human stearoyl-CoA desaturase unique to primates

4 July 2018

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Stearoyl-CoA desaturase is involved in the control of proliferation, anchorage-independent growth, and survival in human transformed cells

4 July 2018

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High stearoyl-CoA desaturase protein and activity levels in simian virus 40 transformed-human lung fibroblasts.

4 July 2018

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Loss of stearoyl-CoA desaturase expression is a frequent event in prostate carcinoma

4 July 2018

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Induction of CCAAT/enhancer-binding protein (C/EBP)-homologous protein/growth arrest and DNA damage-inducible protein 153 expression during inhibition of phosphatidylcholine synthesis is mediated via activation of a C/EBP-activating transcription fa

4 July 2018

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Triglyceride accumulation protects against fatty acid-induced lipotoxicity

4 July 2018

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Stearoyl-CoA desaturase 1 (Scd1) gene overexpression is associated with genetic predisposition to hepatocarcinogenesis in mice and rats

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3002938

Inhibition of phosphatidylcholine synthesis induces expression of the endoplasmic reticulum stress and apoptosis-related protein CCAAT/enhancer-binding protein-homologous protein (CHOP/GADD153).

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3002938

Activator protein-1 and CCAAT/enhancer-binding protein mediated GADD153 expression is involved in deoxycholic acid-induced apoptosis

4 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3002938

Targeted disruption of the Chop gene delays endoplasmic reticulum stress-mediated diabetes

4 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3002938

XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3002938

Gadd153 sensitizes cells to endoplasmic reticulum stress by down-regulating Bcl2 and perturbing the cellular redox state

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3002938

Regulated translation initiation controls stress-induced gene expression in mammalian cells

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3002938

The expression of fatty acid synthase (FASE) is an early event in the development and progression of squamous cell carcinoma of the lung

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3002938

CHOP is implicated in programmed cell death in response to impaired function of the endoplasmic reticulum

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3002938

Apoptosis triggered by 1-O-octadecyl-2-O-methyl-rac-glycero-3-phosphocholine is prevented by increased expression of CTP:phosphocholine cytidylyltransferase

4 July 2018

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Elevated expression of fatty acid synthase and fatty acid synthetic activity in colorectal neoplasia.

4 July 2018

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Cell cycle regulation of membrane phospholipid metabolism.

4 July 2018

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Fatty acid synthesis: a potential selective target for antineoplastic therapy

4 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3002938

Partial characterization of a cDNA for human stearoyl-CoA desaturase and changes in its mRNA expression in some normal and malignant tissues

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3002938

Dietary control of lipogenesis in vivo in host tissues and tumors of mice bearing Ehrlich ascites carcinoma.

4 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3002938

Role of cholesterogenesis and isoprenoid synthesis in DNA replication and cell growth

4 July 2018

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Control of lipid metabolism in hepatomas: insensitivity of rate of fatty acid and cholesterol synthesis by mouse hepatoma BW7756 to fasting and to feedback control.

4 July 2018

1 reference

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Fatty acid synthase drives the synthesis of phospholipids partitioning into detergent-resistant membrane microdomains.

4 July 2018

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Incorporation and metabolism of exogenous fatty acids by cultured normal and tumoral glial cells.

21 January 2018

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Altered membrane free unsaturated fatty acid composition in human colorectal cancer tissue

21 January 2018

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Overexpression of fatty acid synthase is an early and common event in the development of prostate cancer.

21 January 2018

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Saturated fatty acid-induced apoptosis in MDA-MB-231 breast cancer cells. A role for cardiolipin

21 January 2018

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Induction of stearoyl-CoA desaturase protects human arterial endothelial cells against lipotoxicity

21 January 2018

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Unsaturated fatty acids promote hepatoma proliferation and progression through downregulation of the tumor suppressor PTEN.

21 January 2018

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Synthesis and biological activity of a potent and orally bioavailable SCD inhibitor (MF-438).

21 January 2018

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Decrease in membrane phospholipid unsaturation induces unfolded protein response

21 January 2018

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Oleate activates phosphatidylinositol 3-kinase and promotes proliferation and reduces apoptosis of MDA-MB-231 breast cancer cells, whereas palmitate has opposite effects.

30 October 2018

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Phospholipid content and composition of human meningiomas

30 October 2018

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Selective activation of the fatty acid synthesis pathway in human prostate cancer

21 January 2018

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12 December 2020

Composition and turnover of phospholipids and neutral lipids in human breast cancer and reference tissues

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12 December 2020

Membrane fatty acids of breast carcinoma: contribution of host fatty acids and tumor properties

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12 December 2020

A genetic defect in phosphatidylcholine biosynthesis triggers apoptosis in Chinese hamster ovary cells

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12 December 2020

Subcutaneous, omentum and tumor fatty acid composition, and serum insulin status in patients with benign or cancerous ovarian or endometrial tumors. Do tumors preferentially utilize polyunsaturated fatty acids?

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12 December 2020

Enzymes of the fatty acid synthesis pathway are highly expressed in in situ breast carcinoma

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12 December 2020

Phosphorylation of the alpha-subunit of the eukaryotic initiation factor-2 (eIF2alpha) reduces protein synthesis and enhances apoptosis in response to proteasome inhibition

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12 December 2020

10.1371/JOURNAL.PONE.0014363

Identifiers

DOI

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29 July 2017

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29 July 2017

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