Mechanism-based inhibitors of serine proteases with high selectivity through optimization of S' subsite binding. (Q33782834)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19394830%20AND%20SRC:MED&resulttype=core&format=json

26 January 2020

title

Mechanism-based inhibitors of serine proteases with high selectivity through optimization of S' subsite binding (English)

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26 January 2020

4

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26 January 2020

author name string

Yi Li

1

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26 January 2020

Dengfeng Dou

2

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26 January 2020

Guijia He

3

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26 January 2020

William C Groutas

5

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26 January 2020

language of work or name

English

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publication date

12 April 2009

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Bioorganic & Medicinal Chemistry

26 January 2020

published in

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26 January 2020

volume

17

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26 January 2020

issue

10

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26 January 2020

page(s)

3536-3542

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X-ray Snapshot of the Mechanism of Inactivation of Human Neutrophil Elastase by 1,2,5-Thiadiazolidin-3-one 1,1-Dioxide Derivatives †

26 January 2020

cites work

1 reference

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4 July 2018

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Role of apoptosis in the pathogenesis of COPD and pulmonary emphysema

4 July 2018

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Pulmonary and systemic oxidant/antioxidant imbalance in chronic obstructive pulmonary disease

4 July 2018

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The pathogenesis of chronic obstructive pulmonary disease: advances in the past 100 years

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Proteases and emphysema

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Neutrophil elastase contributes to cigarette smoke-induced emphysema in mice

4 July 2018

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Alveolar wall apoptosis causes lung destruction and emphysematous changes

4 July 2018

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Surflex: fully automatic flexible molecular docking using a molecular similarity-based search engine

4 July 2018

1 reference

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Neutrophils and protease/antiprotease imbalance

4 July 2018

1 reference

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Inflammation and repair processes in chronic obstructive pulmonary disease

4 July 2018

1 reference

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Structure-based design of a general class of mechanism-based inhibitors of the serine proteinases employing a novel amino acid-derived heterocyclic scaffold

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2853036

The crystal structure of PR3, a neutrophil serine proteinase antigen of Wegener's granulomatosis antibodies

4 July 2018

1 reference

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On the size of the active site in proteases. I. Papain

4 July 2018

1 reference

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The behavior and significance of slow-binding enzyme inhibitors

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2853036

Proteinase 3. A distinct human polymorphonuclear leukocyte proteinase that produces emphysema in hamsters

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2853036

Structure of human neutrophil elastase in complex with a peptide chloromethyl ketone inhibitor at 1.84-A resolution

4 July 2018

1 reference

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Substrate and inhibitor studies on proteinase 3

4 July 2018

1 reference

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Human neutrophil proteinase 3: mapping of the substrate binding site using peptidyl thiobenzyl esters

4 July 2018

1 reference

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Inspection of the binding sites of proteinase3 for the design of a highly specific substrate

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2853036

Potent inhibition of human leukocyte elastase by 1,2,5-thiadiazolidin-3-one 1,1 dioxide-based sulfonamide derivatives

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2853036

Mechanism-based inactivation of human leukocyte elastase via an enzyme-induced sulfonamide fragmentation process

30 October 2018

1 reference

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Apoptosis and emphysema: the missing link.

30 October 2018

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Compared action of neutrophil proteinase 3 and elastase on model substrates. Favorable effect of S'-P' interactions on proteinase 3 catalysts

30 October 2018

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Inhibition of serine proteases by functionalized sulfonamides coupled to the 1,2,5-thiadiazolidin-3-one 1,1 dioxide scaffold

30 October 2018

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Potent and specific inhibition of human leukocyte elastase, cathepsin G and proteinase 3 by sulfone derivatives employing the 1,2,5-thiadiazolidin-3-one 1,1 dioxide scaffold

30 October 2018

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New mechanism-based inactivators of trypsin-like proteinases. Selective inactivation of urokinase by functionalized cyclopeptides incorporating a sulfoniomethyl-substituted m-aminobenzoic acid residue.

30 October 2018

1 reference

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Pathogenesis of chronic obstructive pulmonary disease

30 October 2018

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Novel Examples of 3-Aza-Grob Fragmentation

30 October 2018

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12 December 2020

Mechanism-based enzyme inactivators

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12 December 2020

Future research directions in chronic obstructive pulmonary disease

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12 December 2020

Epithelial responses to oxidative stress in chronic obstructive pulmonary disease: lessons from expression profiling

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12 December 2020

Utilization of the 1,2,5-thiadiazolidin-3-one 1,1 dioxide scaffold in the design of potent inhibitors of serine proteases: SAR studies using carboxylates

1 reference

12 December 2020

10.1016/J.BMC.2009.04.011

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19394830%20AND%20SRC:MED&resulttype=core&format=json

26 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19394830%20AND%20SRC:MED&resulttype=core&format=json

26 January 2020

PubMed publication ID

19394830

1 reference