Apoptosis induced by JAK2 inhibition is mediated by Bim and enhanced by the BH3 mimetic ABT-737 in JAK2 mutant human erythroid cells. (Q33788708)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20160166%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

title

Apoptosis induced by JAK2 inhibition is mediated by Bim and enhanced by the BH3 mimetic ABT-737 in JAK2 mutant human erythroid cells (English)

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18 January 2020

1 reference

7

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18 January 2020

Daniel G Tenen

9

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18 January 2020

8

Ulrich Steidl

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18 January 2020

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Susumu Kobayashi

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18 January 2020

author name string

Britta Will

1

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18 January 2020

Tanya Siddiqi

2

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18 January 2020

Meritxell Alberich Jordà

3

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18 January 2020

Takeshi Shimamura

4

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18 January 2020

Katarina Luptakova

5

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18 January 2020

Philipp B Staber

6

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18 January 2020

language of work or name

English

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publication date

16 February 2010

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18 January 2020

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18 January 2020

volume

115

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18 January 2020

page(s)

2901-2909

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18 January 2020

issue

14

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betaTrCP- and Rsk1/2-mediated degradation of BimEL inhibits apoptosis

18 January 2020

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1 reference

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Erythropoietin-induced phosphorylation/degradation of BIM contributes to survival of erythroid cells

4 July 2018

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Treatment of B-RAF mutant human tumor cells with a MEK inhibitor requires Bim and is enhanced by a BH3 mimetic

4 July 2018

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4 July 2018

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4 July 2018

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Gefitinib-induced killing of NSCLC cell lines expressing mutant EGFR requires BIM and can be enhanced by BH3 mimetics

4 July 2018

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4 July 2018

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Induction of BIM is essential for apoptosis triggered by EGFR kinase inhibitors in mutant EGFR-dependent lung adenocarcinomas

4 July 2018

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JAK kinases overexpression promotes in vitro cell transformation

4 July 2018

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ERK1/2-dependent phosphorylation of BimEL promotes its rapid dissociation from Mcl-1 and Bcl-xL

4 July 2018

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4 July 2018

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Bim and Bad mediate imatinib-induced killing of Bcr/Abl+ leukemic cells, and resistance due to their loss is overcome by a BH3 mimetic.

4 July 2018

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"Oncogenic shock": explaining oncogene addiction through differential signal attenuation

4 July 2018

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JAK2T875N is a novel activating mutation that results in myeloproliferative disease with features of megakaryoblastic leukemia in a murine bone marrow transplantation model

4 July 2018

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JAK2 V617F tyrosine kinase mutation in cell lines derived from myeloproliferative disorders

4 July 2018

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An alternative inhibitor overcomes resistance caused by a mutation of the epidermal growth factor receptor.

4 July 2018

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An inhibitor of Bcl-2 family proteins induces regression of solid tumours

4 July 2018

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Identification of an acquired JAK2 mutation in polycythemia vera

4 July 2018

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4 July 2018

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Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis

4 July 2018

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4 July 2018

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A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera

4 July 2018

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4 July 2018

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Phosphorylation of Bim-EL by Erk1/2 on serine 69 promotes its degradation via the proteasome pathway and regulates its proapoptotic function.

4 July 2018

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Activation of the ERK1/2 signaling pathway promotes phosphorylation and proteasome-dependent degradation of the BH3-only protein, Bim.

4 July 2018

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4 July 2018

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4 July 2018

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4 July 2018

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4 July 2018

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4 July 2018

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Expression of Bcl-x in erythroid precursors from patients with polycythemia vera

4 July 2018

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Bim: a novel member of the Bcl-2 family that promotes apoptosis

4 July 2018

1 reference

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The cytoplasmic region of the erythropoietin receptor contains nonoverlapping positive and negative growth-regulatory domains

4 July 2018

1 reference

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Differentiation in erythroleukemic cells and their somatic hybrids

4 July 2018

1 reference

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Activity of the BH3 mimetic ABT-737 on polycythemia vera erythroid precursor cells.

4 July 2018

1 reference

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Conformational change and mitochondrial translocation of Bax accompany proteasome inhibitor-induced apoptosis of chronic lymphocytic leukemic cells.

30 October 2018

1 reference

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Calpain-mediated X-linked inhibitor of apoptosis degradation in neutrophil apoptosis and its impairment in chronic neutrophilic leukemia

30 October 2018

1 reference

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Myeloproliferative disorders

30 October 2018

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12 December 2020

Regulatory phosphorylation of Bim: sorting out the ERK from the JNK

1 reference

12 December 2020

Constitutive activation of STAT5 and Bcl-xL overexpression can induce endogenous erythroid colony formation in human primary cells

1 reference

12 December 2020

The JAK2-V617F mutation is frequently present at diagnosis in patients with essential thrombocythemia and polycythemia vera

1 reference

12 December 2020

10.1182/BLOOD-2009-03-209544

Identifiers

DOI

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18 January 2020

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18 January 2020

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