Polycystin-1 protein level determines activity of the Galpha12/JNK apoptosis pathway (Q33795938)

29 July 2017

Polycystin-1 protein level determines activity of the Galpha12/JNK apoptosis pathway (English)

1 reference

29 July 2017

Wanfeng Yu

1

1 reference

29 July 2017

Tianqing Kong

2

1 reference

29 July 2017

Sarah Beaudry

3

1 reference

29 July 2017

Mei Tran

4

1 reference

29 July 2017

Hideyuki Negoro

5

1 reference

29 July 2017

Vijay Yanamadala

6

1 reference

29 July 2017

Bradley M Denker

7

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29 July 2017

language of work or name

English

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publication date

27 January 2010

1 reference

29 July 2017

9

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Journal of Biological Chemistry

inferred from page(s)

published in

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29 July 2017

285

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29 July 2017

14

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29 July 2017

10243-10251

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describes a project that uses

29 July 2017

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC2856229/fullTextXML

inferred from PubMed Central ID database lookup

cites work

G alpha 12 inhibits alpha2 beta1 integrin-mediated Madin-Darby canine kidney cell attachment and migration on collagen-I and blocks tubulogenesis

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Heterotrimeric G proteins and apoptosis: intersecting signaling pathways leading to context dependent phenotypes

4 July 2018

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Polycystins and primary cilia: primers for cell cycle progression

4 July 2018

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Homophilic and heterophilic polycystin 1 interactions regulate E-cadherin recruitment and junction assembly in MDCK cells

4 July 2018

1 reference

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Galpha12 regulates protein interactions within the MDCK cell tight junction and inhibits tight-junction assembly.

4 July 2018

1 reference

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Polycystin-1 induces cell migration by regulating phosphatidylinositol 3-kinase-dependent cytoskeletal rearrangements and GSK3beta-dependent cell cell mechanical adhesion

4 July 2018

1 reference

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Galpha12 stimulates apoptosis in epithelial cells through JNK1-mediated Bcl-2 degradation and up-regulation of IkappaBalpha

4 July 2018

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The isolated polycystin-1 COOH-terminal can activate or block polycystin-1 signaling.

4 July 2018

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Biologic functions of the G12 subfamily of heterotrimeric g proteins: growth, migration, and metastasis

4 July 2018

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Heptahelical and other G-protein-coupled receptors (GPCRs) signaling

4 July 2018

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Polycystin-1 induces resistance to apoptosis through the phosphatidylinositol 3-kinase/Akt signaling pathway.

4 July 2018

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Overexpression of PKD1 causes polycystic kidney disease

4 July 2018

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Polycystin-1, STAT6, and P100 function in a pathway that transduces ciliary mechanosensation and is activated in polycystic kidney disease

4 July 2018

1 reference

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Receptors coupled to heterotrimeric G proteins of the G12 family

4 July 2018

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Polycystin-1L2 is a novel G-protein-binding protein

4 July 2018

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Galpha12 regulates epithelial cell junctions through Src tyrosine kinases

4 July 2018

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Native polycystin 2 functions as a plasma membrane Ca2+-permeable cation channel in renal epithelia

4 July 2018

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Zonula occludens-1 is a scaffolding protein for signaling molecules. Galpha(12) directly binds to the Src homology 3 domain and regulates paracellular permeability in epithelial cells

4 July 2018

1 reference

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Polycystin-1 activation of c-Jun N-terminal kinase and AP-1 is mediated by heterotrimeric G proteins

4 July 2018

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Polycystin-1, the gene product of PKD1, induces resistance to apoptosis and spontaneous tubulogenesis in MDCK cells

4 July 2018

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Coordinate expression of the autosomal dominant polycystic kidney disease proteins, polycystin-2 and polycystin-1, in normal and cystic tissue.

4 July 2018

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Interaction between RGS7 and polycystin

4 July 2018

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Differential behavior of E-cadherin and occludin in their colocalization with ZO-1 during the establishment of epithelial cell polarity

4 July 2018

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Polycystin, the polycystic kidney disease 1 protein, is expressed by epithelial cells in fetal, adult, and polycystic kidney

4 July 2018

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Bcl-2-deficient mice demonstrate fulminant lymphoid apoptosis, polycystic kidneys, and hypopigmented hair

4 July 2018

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G proteins: critical control points for transmembrane signals

4 July 2018

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Differential coupling of G protein alpha subunits to seven-helix receptors expressed in Xenopus oocytes.

4 July 2018

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Apoptosis and loss of renal tissue in polycystic kidney diseases

4 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856229

Stable knockdown of polycystin-1 confers integrin-alpha2beta1-mediated anoikis resistance.

4 July 2018

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Crossref

https://api.crossref.org/works/10.1074%2FJBC.M109.070821

The polycystic kidney disease-1 protein, polycystin-1, binds and activates heterotrimeric G-proteins in vitro.

21 January 2018

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Crossref

https://api.crossref.org/works/10.1074%2FJBC.M109.070821

Galpha12 and Galpha13 negatively regulate the adhesive functions of cadherin.

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M109.070821

Pkd1 regulates immortalized proliferation of renal tubular epithelial cells through p53 induction and JNK activation

21 January 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856229

Dysregulation of cellular proliferation and apoptosis mediates human autosomal dominant polycystic kidney disease (ADPKD).

30 October 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2856229

Interactions between the amino- and carboxyl-terminal regions of G alpha subunits: analysis of mutated G alpha o/G alpha i2 chimeras

30 October 2018

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PubMed

https://pubmed.ncbi.nlm.nih.gov/20106977

12 December 2020

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Constitutive activation of G-proteins by polycystin-1 is antagonized by polycystin-2

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20106977

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1074/JBC.M109.070821

1 reference

29 July 2017

1 reference

29 July 2017

1 reference