Overcoming the barriers to xenotransplantation: prospects for the future (Q33801035)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20402385%20AND%20SRC:MED&resulttype=core&format=json

31 January 2020

review article

1 reference

title

Overcoming the barriers to xenotransplantation: prospects for the future (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20402385%20AND%20SRC:MED&resulttype=core&format=json

31 January 2020

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20402385%20AND%20SRC:MED&resulttype=core&format=json

31 January 2020

2

David K C Cooper

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20402385%20AND%20SRC:MED&resulttype=core&format=json

31 January 2020

publication date

1 March 2010

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20402385%20AND%20SRC:MED&resulttype=core&format=json

Expert Review of Clinical Immunology

31 January 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20402385%20AND%20SRC:MED&resulttype=core&format=json

31 January 2020

volume

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20402385%20AND%20SRC:MED&resulttype=core&format=json

31 January 2020

page(s)

219-230

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20402385%20AND%20SRC:MED&resulttype=core&format=json

31 January 2020

issue

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20402385%20AND%20SRC:MED&resulttype=core&format=json

Impact of thrombocytopenia on survival of baboons with genetically modified pig liver transplants: clinical relevance

31 January 2020

cites work

1 reference

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T regulatory cells in xenotransplantation

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4 July 2018

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4 July 2018

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Role for CD47-SIRPalpha signaling in xenograft rejection by macrophages

4 July 2018

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4 July 2018

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Reactivity of human natural antibodies to endothelial cells from Galalpha(1,3)Gal-deficient pigs

4 July 2018

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Increased immunosuppression, not anticoagulation, extends cardiac xenograft survival

4 July 2018

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Selected physiologic compatibilities and incompatibilities between human and porcine organ systems

4 July 2018

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Allosensitized humans are at no greater risk of humoral rejection of GT-KO pig organs than other humans

4 July 2018

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Incidence and cytotoxicity of antibodies in cynomolgus monkeys directed to nonGal antigens, and their relevance for experimental models.

4 July 2018

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alpha1,3-Galactosyltransferase gene-knockout pig heart transplantation in baboons with survival approaching 6 months

4 July 2018

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Acute rejection is associated with antibodies to non-Gal antigens in baboons using Gal-knockout pig kidneys

4 July 2018

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HLA-E expression on porcine cells: protection from human NK cytotoxicity depends on peptide loading

4 July 2018

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Terminal sialic acid residues on human glycophorin A are recognized by porcine kupffer cells

4 July 2018

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Carbohydrates in xenotransplantation.

4 July 2018

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Beyond antibody-mediated rejection: hyperacute lung rejection as a paradigm for dysregulated inflammation

4 July 2018

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''Homologous restriction'' in complement lysis: roles of membrane complement regulators.

4 July 2018

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Human polymorphonuclear neutrophils are recruited by porcine chemokines acting on CXC chemokine receptor 2, and platelet-activating factor

4 July 2018

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An HLA-E single chain trimer inhibits human NK cell reactivity towards porcine cells

4 July 2018

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Which patients first? Planning the first clinical trial of xenotransplantation: a case for cardiac bridging

4 July 2018

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4 July 2018

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4 July 2018

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Donor-specific B-cell tolerance after ABO-incompatible infant heart transplantation

4 July 2018

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Xenotransplantation: infectious risk revisited

4 July 2018

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Acute vascular rejection of xenografts: roles of natural and elicited xenoreactive antibodies in activation of vascular endothelial cells and induction of procoagulant activity

4 July 2018

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Thromboregulatory manifestations in human CD39 transgenic mice and the implications for thrombotic disease and transplantation

4 July 2018

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Lack of galactose-alpha-1,3-galactose expression on porcine endothelial cells prevents complement-induced lysis but not direct xenogeneic NK cytotoxicity.

4 July 2018

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Production of alpha-1,3-galactosyltransferase null pigs by means of nuclear transfer with fibroblasts bearing loss of heterozygosity mutations

4 July 2018

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Alloantibody and xenoantibody cross-reactivity in transplantation

4 July 2018

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Human uptake and incorporation of an immunogenic nonhuman dietary sialic acid

4 July 2018

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Porcine cytomegalovirus and coagulopathy in pig-to-primate xenotransplantation

4 July 2018

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Production of alpha 1,3-galactosyltransferase-deficient pigs

4 July 2018

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Protective effects of recombinant human antithrombin III in pig-to-primate renal xenotransplantation

4 July 2018

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Disseminated intravascular coagulation in association with pig-to-primate pulmonary xenotransplantation

4 July 2018

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Molecular incompatibilities in hemostasis between swine and men--impact on xenografting

4 July 2018

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Will the pig solve the transplantation backlog?

4 July 2018

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Loss of N-glycolylneuraminic acid in humans: Mechanisms, consequences, and implications for hominid evolution

4 July 2018

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HLA-G inhibits rolling adhesion of activated human NK cells on porcine endothelial cells

4 July 2018

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ABO-incompatible heart transplantation in infants

4 July 2018

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Innate and adaptive immune responses to nonvascular xenografts: evidence that macrophages are direct effectors of xenograft rejection

4 July 2018

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Porcine aortic endothelial cells transfected with HLA-G are partially protected from xenogeneic human NK cytotoxicity

4 July 2018

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Coagulation and thrombotic disorders associated with pig organ and hematopoietic cell transplantation in nonhuman primates

4 July 2018

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Plasma perfusion by apheresis through a Gal immunoaffinity column successfully depletes anti-Gal antibody: experience with 320 aphereses in baboons

4 July 2018

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Disordered regulation of coagulation and platelet activation in xenotransplantation

4 July 2018

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An approach to the control of disease transmission in pig-to-human xenotransplantation

4 July 2018

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Long-term survival of nonhuman primates receiving life-supporting transgenic porcine kidney xenografts

4 July 2018

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Venular thrombosis is the key event in the pathogenesis of antibody-mediated cardiac rejection

4 July 2018

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Role of complement in xenotransplantation

4 July 2018

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Search for cross-species transmission of porcine endogenous retrovirus in patients treated with living pig tissue. The XEN 111 Study Group

4 July 2018

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Depletion of natural antibodies in non-human primates--a step towards successful discordant xenografting in humans

4 July 2018

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Porcine kidney and heart transplantation in baboons undergoing a tolerance induction regimen and antibody adsorption

4 July 2018

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Life-supporting pig-to-primate renal xenotransplantation using genetically modified donors.

4 July 2018

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Xenoantigens and xenoantibodies

4 July 2018

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Intravenous infusion of Galalpha1-3Gal oligosaccharides in baboons delays hyperacute rejection of porcine heart xenografts

4 July 2018

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Removal of anti-porcine natural antibodies from human and nonhuman primate plasma in vitro and in vivo by a Galalpha1-3Galbeta1-4betaGlc-X immunoaffinity column

4 July 2018

1 reference

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HLA-Cw3 expression on porcine endothelial cells protects against xenogeneic cytotoxicity mediated by a subset of human NK cells.

4 July 2018

1 reference

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Human natural killer lymphocytes directly recognize evolutionarily conserved oligosaccharide ligands expressed by xenogeneic tissues

4 July 2018

1 reference

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Clinical xenotransplantation: past, present and future

4 July 2018

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In vivo immunoadsorption of antipig antibodies in baboons using a specific Gal(alpha)1-3Gal column

4 July 2018

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A histopathologic grading system of hyperacute (humoral, antibody-mediated) cardiac xenograft and allograft rejection

4 July 2018

1 reference

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Carbohydrate antigens of pig tissues reacting with human natural antibodies as potential targets for hyperacute vascular rejection in pig-to-man organ xenotransplantation.

4 July 2018

1 reference

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Activation of intragraft endothelial and mononuclear cells during discordant xenograft rejection

4 July 2018

1 reference

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Endothelial cell activation and thromboregulation during xenograft rejection

4 July 2018

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The generation of transgenic pigs as potential organ donors for humans.

4 July 2018

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Identification of alpha-galactosyl and other carbohydrate epitopes that are bound by human anti-pig antibodies: relevance to discordant xenografting in man.

4 July 2018

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Man, apes, and Old World monkeys differ from other mammals in the expression of alpha-galactosyl epitopes on nucleated cells.

4 July 2018

1 reference

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Histopathology of hyperacute rejection of the heart: experimental and clinical observations in allografts and xenografts

4 July 2018

1 reference

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Protection of mammalian cells from complement-mediated lysis by transfection of human membrane cofactor protein and decay-accelerating factor

4 July 2018

1 reference

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Inhibition of complement-mediated endothelial cell cytotoxicity by decay-accelerating factor. Potential for prevention of xenograft hyperacute rejection

4 July 2018

1 reference

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Pig kidney transplantation in baboons: anti-Gal(alpha)1-3Gal IgM alone is associated with acute humoral xenograft rejection and disseminated intravascular coagulation

4 July 2018

1 reference

The role of anti-non-Gal antibodies in the development of acute humoral xenograft rejection of hDAF transgenic porcine kidneys in baboons receiving anti-Gal antibody neutralization therapy

21 January 2018

1 reference

The neutrophil: the unnoticed threat in xenotransplantation?

21 January 2018

1 reference

Human neutrophil gene expression profiling following xenogeneic encounter with porcine aortic endothelial cells: the occult role of neutrophils in xenograft rejection revealed.

21 January 2018

1 reference

T cell-mediated xenograft rejection: specific tolerance is probably required for long term xenograft survival.

21 January 2018

1 reference

Maintenance triple immunosuppression with cyclosporin A, mycophenolate sodium and steroids allows prolonged survival of primate recipients of hDAF porcine renal xenografts.

21 January 2018

1 reference

Marked prolongation of porcine renal xenograft survival in baboons through the use of alpha1,3-galactosyltransferase gene-knockout donors and the cotransplantation of vascularized thymic tissue

21 January 2018

1 reference

Cardiac xenotransplantation: progress toward the clinic

21 January 2018

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Cardiac xenotransplantation: recent preclinical progress with 3-month median survival

21 January 2018

1 reference

Life-supporting human complement regulator decay accelerating factor transgenic pig liver xenograft maintains the metabolic function and coagulation in the nonhuman primate for up to 8 days.

21 January 2018

1 reference

Anti-N-glycolylneuraminic acid antibodies identified in healthy human serum

21 January 2018

1 reference

Are N-glycolylneuraminic acid (Hanganutziu-Deicher) antigens important in pig-to-human xenotransplantation?

21 January 2018

1 reference

Antibody- and complement-independent phagocytotic and cytolytic activities of human macrophages toward porcine cells

21 January 2018

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Evidence of macrophage receptors capable of direct recognition of xenogeneic epitopes without opsonization

21 January 2018

1 reference

HLA-E/human beta2-microglobulin transgenic pigs: protection against xenogeneic human anti-pig natural killer cell cytotoxicity.

21 January 2018

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Suppression of natural and elicited antibodies in pig-to-baboon heart transplantation using a human anti-human CD154 mAb-based regimen

21 January 2018

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Thrombotic microangiopathic glomerulopathy in human decay accelerating factor-transgenic swine-to-baboon kidney xenografts.

21 January 2018

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Expression of tissue factor and initiation of clotting by human platelets and monocytes after incubation with porcine endothelial cells

21 January 2018

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Complete inhibition of acute humoral rejection using regulated expression of membrane-tethered anticoagulants on xenograft endothelium.

21 January 2018

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Gal alpha 1,3Gal expression on porcine pancreatic islets, testis, spleen, and thymus.

21 January 2018

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A study of the xenoantigenicity of adult pig islets cells

21 January 2018

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Dissecting the instant blood-mediated inflammatory reaction in islet xenotransplantation

21 January 2018

1 reference

Long-term controlled normoglycemia in diabetic non-human primates after transplantation with hCD46 transgenic porcine islets.

21 January 2018

1 reference

Prolonged diabetes reversal after intraportal xenotransplantation of wild-type porcine islets in immunosuppressed nonhuman primates

21 January 2018

1 reference

Long-term survival of neonatal porcine islets in nonhuman primates by targeting costimulation pathways

21 January 2018

1 reference

Knockdown of porcine endogenous retrovirus (PERV) expression by PERV-specific shRNA in transgenic pigs.

21 January 2018

1 reference

Genetically engineered pig red blood cells for clinical transfusion: initial in vitro studies.

21 January 2018

1 reference

Production and characterization of transgenic pigs expressing porcine CTLA4-Ig

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2857338

Achieving permanent survival of islet xenografts by independent manipulation of direct and indirect T-cell responses

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2857338

Characterization of a CD46 transgenic pig and protection of transgenic kidneys against hyperacute rejection in non-immunosuppressed baboons

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2857338

Identification of carbohydrate structures that bind human antiporcine antibodies: implications for discordant xenografting in humans

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2857338

Achieving Permanent Survival of Islet Xenografts by Independent Manipulation of Direct and Indirect T-Cell Responses

30 October 2018

1 reference

Microcoagulation processes after xenotransplantation

21 January 2018

1 reference

Disordered thromboregulation after xenografting

21 January 2018

1 reference

Life-supporting function of genetically modified swine lungs in baboons

21 January 2018

1 reference

12 December 2020

Late onset of development of natural anti-nonGal antibodies in infant humans and baboons: implications for xenotransplantation in infants

1 reference

12 December 2020

Regulatory aspects of pig-to-human islet transplantation

1 reference

12 December 2020

In vitro investigation of pig cells for resistance to human antibody-mediated rejection

1 reference

12 December 2020

HLA-G inhibits the transendothelial migration of human NK cells

1 reference

12 December 2020

Life supporting function for over one month of a transgenic porcine heart in a baboon

1 reference

12 December 2020

High-dose porcine hematopoietic cell transplantation combined with CD40 ligand blockade in baboons prevents an induced anti-pig humoral response

1 reference

12 December 2020

Physiological aspects of pig-to-primate renal xenotransplantation

1 reference

12 December 2020

Xenogeneic thymokidney and thymic tissue transplantation in a pig-to-baboon model: I. Evidence for pig-specific T-cell unresponsiveness

1 reference

12 December 2020

Human anti-porcine xenogeneic T cell response. Evidence for allelic specificity of mixed leukocyte reaction and for both direct and indirect pathways of recognition

1 reference

12 December 2020

Thrombin inhibition in an ex vivo model of porcine heart xenograft hyperacute rejection

1 reference

12 December 2020

Simultaneous expression by porcine aorta endothelial cells of glycosphingolipids bearing the major epitope for human xenoreactive antibodies (Gal?1?3Gal), blood group H determinant andN-glycolylneuraminic acid

1 reference

12 December 2020

Transgenic pigs expressing human CD59 and decay-accelerating factor produce an intrinsic barrier to complement-mediated damage

1 reference

12 December 2020

Effect of porcine endothelial tissue factor pathway inhibitor on human coagulation factors

1 reference

12 December 2020

The evaluation of thrombomodulin activity in porcine to human xenotransplantation

1 reference

12 December 2020

Delayed xenograft rejection of pig-to-baboon cardiac transplants after cobra venom factor therapy

1 reference

12 December 2020

Activation of human platelets by the membrane-expressed A1 domain of von Willebrand factor

1 reference

12 December 2020

Humoral responses to pig-to-baboon cardiac transplantation: implications for the pathogenesis and treatment of acute vascular rejection and for accommodation

1 reference

12 December 2020

No evidence of pig DNA or retroviral infection in patients with short-term extracorporeal connection to pig kidneys

1 reference

12 December 2020

Pig islet xenografts are susceptible to "anti-pig" but not Gal alpha(1,3)Gal antibody plus complement in Gal o/o mice

1 reference

12 December 2020

Three-month survival of HDAFF transgenic pig hearts transplanted into primates

1 reference

12 December 2020

Fetal porcine islet-like cell clusters transplanted to cynomolgus monkeys: an immunohistochemical study

1 reference

12 December 2020

Combined histocompatibility leukocyte antigen-matched donor bone marrow and renal transplantation for multiple myeloma with end stage renal disease: the induction of allograft tolerance through mixed lymphohematopoietic chimerism

1 reference

12 December 2020

Thrombotic microangiopathy and graft arteriopathy in pig hearts following transplantation into baboons

1 reference

12 December 2020

Hyperacute rejection in a discordant (pig to baboon) cardiac xenograft model

1 reference

12 December 2020

Effects of cyclosporine and antibody adsorption on pig cardiac xenograft survival in the baboon

1 reference

12 December 2020

Genetically engineered pigs

1 reference

12 December 2020

Evidence that intravenously administered alpha-galactosyl carbohydrates reduce baboon serum cytotoxicity to pig kidney cells (PK15) and transplanted pig hearts

1 reference

12 December 2020

Distribution of the major xenoantigen (gal (alpha 1-3)gal) for pig to human xenografts

1 reference

12 December 2020

Mixed allogeneic chimerism and renal allograft tolerance in cynomolgus monkeys

1 reference

12 December 2020

Heart transplantation in baboons using alpha1,3-galactosyltransferase gene-knockout pigs as donors: initial experience

1 reference

12 December 2020

How strong is the T cell response in the pig-to-primate model?

1 reference

12 December 2020

Allosensitization does not increase the risk of xenoreactivity to alpha1,3-galactosyltransferase gene-knockout miniature swine in patients on transplantation waiting lists

1 reference

12 December 2020

Antibodies directed to pig non-Gal antigens in naïve and sensitized baboons

1 reference

12 December 2020

Reduction of early graft loss after intraportal porcine islet transplantation in monkeys

1 reference

12 December 2020

Identifiers

DOI

10.1586/ECI.09.81

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20402385%20AND%20SRC:MED&resulttype=core&format=json

31 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20402385%20AND%20SRC:MED&resulttype=core&format=json

31 January 2020

1 reference