Detailed physiologic characterization reveals diverse mechanisms for novel genetic Loci regulating glucose and insulin metabolism in humans (Q33803511)

29 July 2017

Detailed physiologic characterization reveals diverse mechanisms for novel genetic Loci regulating glucose and insulin metabolism in humans (English)

1 reference

29 July 2017

0 references

1 reference

4

1 reference

29 July 2017

7

1 reference

29 July 2017

44

1 reference

29 July 2017

53

1 reference

29 July 2017

55

Anke Tönjes

0 references

Inês Barroso

59

Inês Barroso

0 references

Johanna Kuusisto

36

Johanna Kuusisto

0 references

Claudia Langenberg

2

Claudia Langenberg

0 references

Ann-Christine Syvänen

52

Ann-Christine Syvänen

0 references

Jaakko Tuomilehto

54

Jaakko Tuomilehto

0 references

Francis Collins

25

Francis S Collins

0 references

Narisu Narisu

41

Narisu Narisu

1 reference

29 July 2017

23

Yvonne Böttcher

1 reference

29 July 2017

60

Thomas Quertermous

1 reference

29 July 2017

3

Marie-France Hivert

1 reference

29 July 2017

Avan A Sayer

46

0 references

Josée Dupuis

Josée Dupuis

6

0 references

Cyrus Cooper

Cyrus C Cooper

26

0 references

Karen L Mohlke

39

Karen L Mohlke

1 reference

29 July 2017

13

Björn Zethelius

1 reference

29 July 2017

Elaine M Dennison

27

0 references

Mark McCarthy

Mark I McCarthy

64

0 references

Michael Stumvoll

50

Michael Stumvoll

1 reference

29 July 2017

62

Nicholas J Wareham

1 reference

29 July 2017

37

Markku Laakso

1 reference

29 July 2017

18

Michael Boehnke

1 reference

29 July 2017

9

Anne U Jackson

1 reference

29 July 2017

1

Erik Ingelsson

1 reference

29 July 2017

49

Heather M Stringham

1 reference

29 July 2017

19

Lori L Bonnycastle

1 reference

29 July 2017

58

Lars Lind

1 reference

29 July 2017

63

James B Meigs

1 reference

29 July 2017

5

Valeriya Lyssenko

1 reference

29 July 2017

65

Leif Groop

1 reference

29 July 2017

33

Bo Isomaa

1 reference

29 July 2017

20

Stefan R Bornstein

1 reference

29 July 2017

47

Peter E H Schwarz

1 reference

29 July 2017

29

Ele Ferrannini

1 reference

29 July 2017

15

Richard N Bergman

1 reference

29 July 2017

30

Caroline S Fox

1 reference

29 July 2017

35

Peter Kovacs

1 reference

29 July 2017

Themistocles L Assimes

10

Themistocles L Assimes

1 reference

29 July 2017

11

Peter Shrader

1 reference

29 July 2017

Suzannah J. Bumpstead

22

Suzannah J Bumpstead

1 reference

29 July 2017

24

Peter Chines

1 reference

29 July 2017

28

Michael R Erdos

1 reference

29 July 2017

31

Jürgen Graessler

1 reference

29 July 2017

40

Mario A Morken

1 reference

29 July 2017

48

Laura J Scott

1 reference

29 July 2017

56

Timo T Valle

1 reference

29 July 2017

66

Richard M Watanabe

1 reference

29 July 2017

34

Karen A Jameson

1 reference

29 July 2017

43

Laura Pascoe

1 reference

29 July 2017

68

MAGIC investigators

1 reference

29 July 2017

8

Stephen Sharp

1 reference

29 July 2017

38

Claes Ladenvall

1 reference

29 July 2017

14

Fahim A Abbasi

1 reference

29 July 2017

51

Amy J Swift

1 reference

29 July 2017

Joshua W Knowles

12

1 reference

29 July 2017

Antje Bergmann

16

1 reference

29 July 2017

Christian Berne

17

1 reference

29 July 2017

Thomas A Buchanan

21

1 reference

29 July 2017

Ke Hao

32

1 reference

29 July 2017

David M Nathan

42

1 reference

29 July 2017

John R Petrie

45

1 reference

29 July 2017

Gordon H Williams

57

1 reference

29 July 2017

Mark Walker

61

1 reference

29 July 2017

Jose C Florez

67

1 reference

29 July 2017

language of work or name

English

0 references

publication date

25 February 2010

1 reference

29 July 2017

1 reference

29 July 2017

59

1 reference

29 July 2017

5

1 reference

29 July 2017

1266-1275

1 reference

Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported

29 July 2017

start time

30 August 2021

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2857908

Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2857908

Overexpression of alpha2A-adrenergic receptors contributes to type 2 diabetes

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2857908

Additive effects of genetic variation in GCK and G6PC2 on insulin secretion and fasting glucose

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2857908

A variant in the G6PC2/ABCB11 locus is associated with increased fasting plasma glucose, increased basal hepatic glucose production and increased insulin release after oral and intravenous glucose loads

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2857908

The P446L variant in GCKR associated with fasting plasma glucose and triglyceride levels exerts its effect through increased glucokinase activity in liver

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2857908

Insulin storage and glucose homeostasis in mice null for the granule zinc transporter ZnT8 and studies of the type 2 diabetes-associated variants

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2857908

Deletion of the mouse Slc30a8 gene encoding zinc transporter-8 results in impaired insulin secretion

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2857908

MADD, a splice variant of IG20, is indispensable for MAPK activation and protection against apoptosis upon tumor necrosis factor-alpha treatment

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2857908

Polymorphisms within the novel type 2 diabetes risk locus MTNR1B determine beta-cell function

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2857908

Common variant in MTNR1B associated with increased risk of type 2 diabetes and impaired early insulin secretion

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2857908

Variants in MTNR1B influence fasting glucose levels

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2857908

Genetics meets metabolomics: a genome-wide association study of metabolite profiles in human serum

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2857908

A single-nucleotide polymorphism in a methylatable Foxa2 binding site of the G6PC2 promoter is associated with insulin secretion in vivo and increased promoter activity in vitro

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2857908

Two human ARFGAPs associated with COP-I-coated vesicles.

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2857908

A new multipoint method for genome-wide association studies by imputation of genotypes

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2857908

A variant in CDKAL1 influences insulin response and risk of type 2 diabetes

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2857908

A common haplotype of the glucokinase gene alters fasting glucose and birth weight: association in six studies and population-genetics analyses

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2857908

In vivo expression and functional characterization of the zinc transporter ZnT8 in glucose-induced insulin secretion

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2857908

Mechanisms of impaired fasting glucose and glucose intolerance induced by an approximate 50% pancreatectomy

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2857908

Common genetic variants of the FADS1 FADS2 gene cluster and their reconstructed haplotypes are associated with the fatty acid composition in phospholipids

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2857908

Differential effects of monounsaturated, polyunsaturated and saturated fat ingestion on glucose-stimulated insulin secretion, sensitivity and clearance in overweight and obese, non-diabetic humans.

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2857908

Role of incretin hormones in the regulation of insulin secretion in diabetic and nondiabetic humans

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2857908

The LZT proteins; the LIV-1 subfamily of zinc transporters

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2857908

The relative contributions of insulin resistance and beta-cell dysfunction to the pathophysiology of Type 2 diabetes

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2857908

Diabetes mellitus and genetically programmed defects in beta-cell function

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2857908

Merlin--rapid analysis of dense genetic maps using sparse gene flow trees

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2857908

Mechanisms and physiological significance of the cholinergic control of pancreatic beta-cell function

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2857908

PACSIN 3 is a novel SH3 domain cytoplasmic adapter protein of the pacsin-syndapin-FAP52 gene family.

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2857908

The insulinotropic potency of fatty acids is influenced profoundly by their chain length and degree of saturation

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2857908

Intake of a diet high in trans monounsaturated fatty acids or saturated fatty acids. Effects on postprandial insulinemia and glycemia in obese patients with NIDDM.

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2857908

Proportional proinsulin responses in first-degree relatives of patients with type 2 diabetes mellitus.

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2857908

Comparison of impedance to insulin-mediated glucose uptake in normal subjects and in subjects with latent diabetes

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2857908

Assessment of insulin sensitivity in vivo

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2857908

Equivalence of the insulin sensitivity index in man derived by the minimal model method and the euglycemic glucose clamp

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2857908

Oscillations of lactate released from islets of Langerhans: evidence for oscillatory glycolysis in beta-cells

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2857908

Primary pancreatic beta-cell secretory defect caused by mutations in glucokinase gene in kindreds of maturity onset diabetes of the young.

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2857908

Glucose clamp technique: a method for quantifying insulin secretion and resistance

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2857908

Translating TCF7L2: from gene to function.

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2857908

Polymorphisms in the TCF7L2, CDKAL1 and SLC30A8 genes are associated with impaired proinsulin conversion.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2857908

Insulinogenic indices from insulin and C-peptide: comparison of beta-cell function from OGTT and IVGTT.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2857908

Role of insulin-like growth factor iin maintaining normal glucose homeostasis

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2857908

Minimal model-based insulin sensitivity has greater heritability and a different genetic basis than homeostasis model assessment or fasting insulin

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2857908

Increased proinsulin levels and decreased acute insulin response independently predict the incidence of type 2 diabetes in the insulin resistance atherosclerosis study

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2857908

Reduced insulinotropic effect of gastric inhibitory polypeptide in first-degree relatives of patients with type 2 diabetes

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2857908

Glucose-induced metabolic oscillations parallel those of Ca(2+) and insulin release in clonal insulin-secreting cells. A multiwell approach to oscillatory cell behavior

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2857908

Use of the oral glucose tolerance test to assess insulin release and insulin sensitivity.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2857908

Validation of the insulin sensitivity index (ISI(0,120)): comparison with other measures.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2857908

Insulin sensitivity indices obtained from oral glucose tolerance testing: comparison with the euglycemic insulin clamp.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2857908

Hyperproinsulinemia of type II diabetes is not present before the development of hyperglycemia.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2857908

Hypertriglyceridaemia in subjects with normal and abnormal glucose tolerance: relative contributions of insulin secretion, insulin resistance and suppression of plasma non-esterified fatty acids.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2857908

The pathogenesis of NIDDM involves a defective expression of the GIP receptor

30 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20185807

12 December 2020

inferred from PubMed ID database lookup

Unsaturated fatty acids alter the insulin secretion response of the islets of Langerhans in vitro

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20185807

12 December 2020

inferred from PubMed ID database lookup

Insulin sensitivity indices calculated from basal and OGTT-induced insulin, glucose, and FFA levels

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20185807

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.2337/DB09-1568

1 reference

release_pahjoj5okfecvgwgpi2u5zql7m

29 July 2017

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/pahjoj5okfecvgwgpi2u5zql7m

24 November 2022

mapped directly with Wikidata item

PMCID

2857908

1 reference

29 July 2017

1 reference