Ins2 deficiency augments spontaneous HLA-A*0201-restricted T cell responses to insulin. (Q33805693)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19966211%20AND%20SRC:MED&resulttype=core&format=json

13 February 2020

title

Ins2 deficiency augments spontaneous HLA-A*0201-restricted T cell responses to insulin (English)

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13 February 2020

1 reference

1

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13 February 2020

author name string

Teresa P DiLorenzo

series ordinal

2

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13 February 2020

language of work or name

English

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publication date

4 December 2009

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13 February 2020

published in

Journal of Immunology

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13 February 2020

volume

184

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13 February 2020

issue

2

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13 February 2020

page(s)

658-665

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Thymus-specific deletion of insulin induces autoimmune diabetes

13 February 2020

cites work

1 reference

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4 July 2018

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CTLs are targeted to kill beta cells in patients with type 1 diabetes through recognition of a glucose-regulated preproinsulin epitope

4 July 2018

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4 July 2018

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4 July 2018

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4 July 2018

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Anti-CD3 and nasal proinsulin combination therapy enhances remission from recent-onset autoimmune diabetes by inducing Tregs

4 July 2018

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4 July 2018

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4 July 2018

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Identification of naturally processed HLA-A2--restricted proinsulin epitopes by reverse immunology.

4 July 2018

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Individual nonobese diabetic mice exhibit unique patterns of CD8+ T cell reactivity to three islet antigens, including the newly identified widely expressed dystrophia myotonica kinase

4 July 2018

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Evidence for a primary islet autoantigen (preproinsulin 1) for insulitis and diabetes in the nonobese diabetic mouse

4 July 2018

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Identification of the beta cell antigen targeted by a prevalent population of pathogenic CD8+ T cells in autoimmune diabetes.

4 July 2018

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Acceleration of type 1 diabetes mellitus in proinsulin 2-deficient NOD mice

4 July 2018

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Projection of an immunological self shadow within the thymus by the aire protein

4 July 2018

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Genetics of type 1 diabetes mellitus

4 July 2018

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Identification of an MHC class I-restricted autoantigen in type 1 diabetes by screening an organ-specific cDNA library.

4 July 2018

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Major histocompatibility complex class I-restricted T cells are required for all but the end stages of diabetes development in nonobese diabetic mice and use a prevalent T cell receptor alpha chain gene rearrangement

4 July 2018

1 reference

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The insulin gene is transcribed in the human thymus and transcription levels correlated with allelic variation at the INS VNTR-IDDM2 susceptibility locus for type 1 diabetes.

4 July 2018

1 reference

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Insulin expression in human thymus is modulated by INS VNTR alleles at the IDDM2 locus.

4 July 2018

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An improved method for the detection of peptide-induced upregulation of HLA-A2 molecules on TAP-deficient T2 cells

4 July 2018

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Differential expression of the two nonallelic proinsulin genes in the developing mouse embryo

4 July 2018

1 reference

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Equivalent specificity of peripheral blood and islet-infiltrating CD8+ T lymphocytes in spontaneously diabetic HLA-A2 transgenic NOD mice.

4 July 2018

1 reference

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The diabetogenic, insulin-specific CD8 T cell response primed in the experimental autoimmune diabetes model in RIP-B7.1 mice.

30 October 2018

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Recognition of HLA class I-restricted beta-cell epitopes in type 1 diabetes.

30 October 2018

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30 October 2018

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Millennium award recipient contribution. Identification of children with early onset and high incidence of anti-islet autoantibodies.

30 October 2018

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Shaping of the autoreactive T-cell repertoire by a splice variant of self protein expressed in thymic epithelial cells.

30 October 2018

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IDDM2-VNTR-encoded susceptibility to type 1 diabetes: dominant protection and parental transmission of alleles of the insulin gene-linked minisatellite locus

30 October 2018

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Susceptibility to insulin dependent diabetes mellitus maps to a 4.1 kb segment of DNA spanning the insulin gene and associated VNTR.

30 October 2018

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Major histocompatibility complex class I-deficient NOD-B2mnull mice are diabetes and insulitis resistant

30 October 2018

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12 December 2020

Beta 2-microglobulin-deficient NOD mice do not develop insulitis or diabetes

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12 December 2020

Prevention of insulitis and diabetes in beta 2-microglobulin-deficient non-obese diabetic mice

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12 December 2020

The role of CD8+ T cells in the initiation of insulin-dependent diabetes mellitus

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12 December 2020

Retardation or acceleration of diabetes in NOD/Lt mice mediated by intrathymic administration of candidate beta-cell antigens

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12 December 2020

Intrathymic expression of genes involved in organ specific autoimmune disease

1 reference

12 December 2020

HLA-A*0201-restricted T cells from humanized NOD mice recognize autoantigens of potential clinical relevance to type 1 diabetes

1 reference

12 December 2020

Tolerance to proinsulin-2 is due to radioresistant thymic cells

1 reference

12 December 2020

Improved outcomes in NOD mice treated with a novel Th2 cytokine-biasing NKT cell activator

1 reference

12 December 2020

CD8+ T-cell responses identify beta-cell autoimmunity in human type 1 diabetes

1 reference

12 December 2020

In vivo cytotoxicity of insulin-specific CD8+ T-cells in HLA-A*0201 transgenic NOD mice

1 reference

12 December 2020

The frequency and immunodominance of islet-specific CD8+ T-cell responses change after type 1 diabetes diagnosis and treatment

1 reference

12 December 2020

Insulin expression levels in the thymus modulate insulin-specific autoreactive T-cell tolerance: the mechanism by which the IDDM2 locus may predispose to diabetes

1 reference

12 December 2020

5'-Insulin gene VNTR polymorphism is specific for type 1 diabetes: no association with celiac or Addison's disease

1 reference

12 December 2020

Expression of preproinsulin-2 gene shapes the immune response to preproinsulin in normal mice

1 reference

12 December 2020

Major histocompatibility complex class I molecules are required for the development of insulitis in non-obese diabetic mice

1 reference

12 December 2020

A gene in the HLA class I region contributes to susceptibility to IDDM in the Finnish population. Childhood Diabetes in Finland (DiMe) Study Group

1 reference

12 December 2020

Identifiers

DOI

10.4049/JIMMUNOL.0903414

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19966211%20AND%20SRC:MED&resulttype=core&format=json

13 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19966211%20AND%20SRC:MED&resulttype=core&format=json

13 February 2020

PubMed publication ID

19966211

1 reference