Formation of a vitamin C conjugate of acrolein and its paraoxonase-mediated conversion into 5,6,7,8-tetrahydroxy-4-oxooctanal (Q33806503)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20353174%20AND%20SRC:MED&resulttype=core&format=json

29 January 2020

title

Formation of a vitamin C conjugate of acrolein and its paraoxonase-mediated conversion into 5,6,7,8-tetrahydroxy-4-oxooctanal (English)

1 reference

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29 January 2020

0 references

5

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29 January 2020

author name string

Nicholas G Kesinger

1

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29 January 2020

Brandi L Langsdorf

2

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29 January 2020

Alexandre F Yokochi

3

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29 January 2020

Cristobal L Miranda

4

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29 January 2020

publication date

1 April 2010

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Chemical Research in Toxicology

29 January 2020

published in

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29 January 2020

volume

23

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29 January 2020

issue

4

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29 January 2020

page(s)

836-844

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Covalent interaction of ascorbic acid with natural products

29 January 2020

cites work

1 reference

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Ascorbic acid promotes detoxification and elimination of 4-hydroxy-2(E)-nonenal in human monocytic THP-1 cells

4 July 2018

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Ascorbigen: chemistry, occurrence, and biologic properties

4 July 2018

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Vitamin C and cancer revisited

4 July 2018

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Acrolein: sources, metabolism, and biomolecular interactions relevant to human health and disease

4 July 2018

1 reference

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Quantitation of acrolein-derived (3-hydroxypropyl)mercapturic acid in human urine by liquid chromatography-atmospheric pressure chemical ionization tandem mass spectrometry: effects of cigarette smoking

4 July 2018

1 reference

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Acrolein inhibits cytokine gene expression by alkylating cysteine and arginine residues in the NF-kappaB1 DNA binding domain

4 July 2018

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Acrolein is a major cigarette-related lung cancer agent: Preferential binding at p53 mutational hotspots and inhibition of DNA repair

4 July 2018

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Augmentation of monocyte intracellular ascorbate in vitro protects cells from oxidative damage and inflammatory responses.

4 July 2018

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Pharmacologic ascorbic acid concentrations selectively kill cancer cells: action as a pro-drug to deliver hydrogen peroxide to tissues

4 July 2018

1 reference

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Structure-reactivity studies of serum paraoxonase PON1 suggest that its native activity is lactonase

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2858635

Human paraoxonases (PON1, PON2, and PON3) are lactonases with overlapping and distinct substrate specificities

4 July 2018

1 reference

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Paraoxonase 2 (PON2) expression is upregulated via a reduced-nicotinamide-adenine-dinucleotide-phosphate (NADPH)-oxidase-dependent mechanism during monocytes differentiation into macrophages

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2858635

Paraoxonases 1, 2, and 3, oxidative stress, and macrophage foam cell formation during atherosclerosis development

4 July 2018

1 reference

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Free radicals, oxidants, and antioxidants

4 July 2018

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Rabbit serum paraoxonase 3 (PON3) is a high density lipoprotein-associated lactonase and protects low density lipoprotein against oxidation

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2858635

Michael adducts of ascorbic acid as inhibitors of protein phosphatase 2A and inducers of apoptosis

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2858635

Mutagens from heated Chinese and U.S. cooking oils.

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2858635

gamma-Glutamyl transpeptidase. What does the organization and expression of a multipromoter gene tell us about its functions?

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2858635

Formation of cyclic 1,N2-propanodeoxyguanosine adducts in DNA upon reaction with acrolein or crotonaldehyde

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2858635

Biosynthesis of mercapturic acids from allyl alcohol, allyl esters and acrolein

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2858635

Millimolar concentrations of ascorbic acid in purified human mononuclear leukocytes. Depletion and reaccumulation.

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2858635

Human and murine paraoxonase 1 are host modulators of Pseudomonas aeruginosa quorum-sensing

4 July 2018

1 reference

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Effect of ascorbate on acrolein modification of very low density lipoprotein and uptake of oxidized apolipoprotein e by hepatocytes

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2858635

Glutathione and ascorbic acid enhance recovery of Guinea pig spinal cord white matter following ischemia and acrolein exposure

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2858635

Identification of cytosolic leucyl aminopeptidase (EC 3.4.11.1) as the major cysteinylglycine-hydrolysing activity in rat liver

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2858635

Mouse macrophage paraoxonase 2 activity is increased whereas cellular paraoxonase 3 activity is decreased under oxidative stress

30 October 2018

1 reference

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Acrolein-induced cytotoxicity in cultured human bronchial epithelial cells. Modulation by alpha-tocopherol and ascorbic acid

30 October 2018

1 reference

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A new class of synthetic biological response modifiers: the methylfurylbutyrolactones (Nafocare B)

30 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20353174

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Biogenesis of Ascorbigen, 3-Indolylacetonitrile and Indole-3-carboxylic Acid from D,L-Tryptophan-3-14C in Brassica oleracea L

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20353174

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Characterization of the PON1 active site using modeling simulation, in relation to PON1 lactonase activity

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20353174

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1021/TX900452J

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20353174%20AND%20SRC:MED&resulttype=core&format=json

29 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20353174%20AND%20SRC:MED&resulttype=core&format=json

29 January 2020

1 reference