Oligomerization of membrane-bound Bcl-2 is involved in its pore formation induced by tBid (Q33806534)

29 July 2017

title

Oligomerization of membrane-bound Bcl-2 is involved in its pore formation induced by tBid (English)

1 reference

29 July 2017

Jun Peng

1

1 reference

29 July 2017

Jingzhen Ding

2

1 reference

29 July 2017

Chibing Tan

3

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29 July 2017

Bruce Baggenstoss

4

1 reference

29 July 2017

Zhi Zhang

5

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29 July 2017

Suzanne M Lapolla

6

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29 July 2017

Jialing Lin

7

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29 July 2017

publication date

1 October 2009

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29 July 2017

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29 July 2017

volume

14

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29 July 2017

issue

10

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29 July 2017

page(s)

1145-1153

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Bcl-2 family proteins and cancer

29 July 2017

cites work

1 reference

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A short Nur77-derived peptide converts Bcl-2 from a protector to a killer

4 July 2018

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Bcl-XL inhibits membrane permeabilization by competing with Bax.

4 July 2018

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Targeting the Bcl-2-regulated apoptosis pathway by BH3 mimetics: a breakthrough in anticancer therapy?

4 July 2018

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4 July 2018

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The BCL-2 protein family: opposing activities that mediate cell death

4 July 2018

1 reference

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Embedded together: the life and death consequences of interaction of the Bcl-2 family with membranes

4 July 2018

1 reference

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tBid elicits a conformational alteration in membrane-bound Bcl-2 such that it inhibits Bax pore formation

4 July 2018

1 reference

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Bcl-2 changes conformation to inhibit Bax oligomerization

4 July 2018

1 reference

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Auto-activation of the apoptosis protein Bax increases mitochondrial membrane permeability and is inhibited by Bcl-2

4 July 2018

1 reference

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Promises and challenges of targeting Bcl-2 anti-apoptotic proteins for cancer therapy

4 July 2018

1 reference

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Bcl-2 homodimerization involves two distinct binding surfaces, a topographic arrangement that provides an effective mechanism for Bcl-2 to capture activated Bax

4 July 2018

1 reference

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During apoptosis bcl-2 changes membrane topology at both the endoplasmic reticulum and mitochondria

4 July 2018

1 reference

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Conversion of Bcl-2 from protector to killer by interaction with nuclear orphan receptor Nur77/TR3

4 July 2018

1 reference

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Interaction with a membrane surface triggers a reversible conformational change in Bax normally associated with induction of apoptosis

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2858642

Bid, Bax, and lipids cooperate to form supramolecular openings in the outer mitochondrial membrane

4 July 2018

1 reference

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Colicin crystal structures: pathways and mechanisms for colicin insertion into membranes

4 July 2018

1 reference

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Transient expression of wild-type or mitochondrially targeted Bcl-2 induces apoptosis, whereas transient expression of endoplasmic reticulum-targeted Bcl-2 is protective against Bax-induced cell death

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2858642

Solution structure of the antiapoptotic protein bcl-2

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2858642

Structure of Bax: coregulation of dimer formation and intracellular localization

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2858642

Bcl-2 is a monomeric protein: prevention of homodimerization by structural constraints

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2858642

Bid induces the oligomerization and insertion of Bax into the outer mitochondrial membrane

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2858642

Bax oligomerization is required for channel-forming activity in liposomes and to trigger cytochrome c release from mitochondria

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2858642

Ion channel activity of the BH3 only Bcl-2 family member, BID.

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2858642

Solution structure of BID, an intracellular amplifier of apoptotic signaling

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2858642

Bax in murine thymus is a soluble monomeric protein that displays differential detergent-induced conformations

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2858642

Comparison of the ion channel characteristics of proapoptotic BAX and antiapoptotic BCL-2.

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2858642

Inhibition of Bax channel-forming activity by Bcl-2

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2858642

Channel formation by antiapoptotic protein Bcl-2.

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2858642

BH1 and BH2 domains of Bcl-2 are required for inhibition of apoptosis and heterodimerization with Bax.

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2858642

The bcl-2 candidate proto-oncogene product is a 24-kilodalton integral-membrane protein highly expressed in lymphoid cell lines and lymphomas carrying the t(14;18) translocation

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2858642

The crystal structure of diphtheria toxin

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2858642

Refined structure of the pore-forming domain of colicin A at 2.4 A resolution

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2858642

Bax is present as a high molecular weight oligomer/complex in the mitochondrial membrane of apoptotic cells

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2858642

Diphtheria toxin forms pores of different sizes depending on its concentration in membranes: probable relationship to oligomerization.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2858642

Expression level of Bcl-2 determines anti- or proapoptotic function.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2858642

Voltage-dependent, monomeric channel activity of colicin E1 in artificial membrane vesicles.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2858642

Pro-apoptotic cleavage products of Bcl-xL form cytochrome c-conducting pores in pure lipid membranes

30 October 2018

1 reference

12 December 2020

Lipid interaction of diphtheria toxin and mutants with altered fragment B. 2. Hydrophobic photolabelling and cell intoxication

1 reference

12 December 2020

Characterization of the protein product of bcl-2, the gene involved in human follicular lymphoma

1 reference

12 December 2020

Assembly of Bcl-2 into microsomal and outer mitochondrial membranes

1 reference

12 December 2020

Nonionic detergents induce dimerization among members of the Bcl-2 family

1 reference

12 December 2020

Identification of shallow and deep membrane-penetrating forms of diphtheria toxin T domain that are regulated by protein concentration and bilayer width

1 reference

12 December 2020

Caspase-3-dependent cleavage of Bcl-2 promotes release of cytochrome c

1 reference

12 December 2020

10.1007/S10495-009-0389-8

Identifiers

DOI

1 reference

release_6qbcubgr4jgj5aivhwafipjmq4

29 July 2017

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/6qbcubgr4jgj5aivhwafipjmq4

24 November 2022

mapped directly with Wikidata item

PMC publication ID

2858642

1 reference

29 July 2017

1 reference